Results 81 to 90 of about 40,216 (223)

Fish Sperm Subpopulations Detection, Separation, and Application: Current State and Trends

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
Modern advances in sperm biology highlight the necessity of recognising intra‐ejaculate heterogeneity as a central concept for advancing both the fundamental understanding of fertilisation processes and the development of artificial reproduction techniques in fishes. ABSTRACT Sperm subpopulations represent a fundamental manifestation of intra‐ejaculate
Viktoriya Dzyuba, William V. Holt, Borys Dzyuba   +2 more
wiley   +1 more source

Prognostic Value of Phosphotyrosine Phosphatases in Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2018
Background/Aims: During the occurrence and progression of hepatocellular carcinoma (HCC), phosphotyrosine phosphatases (PTPs) are usually described as tumor suppressors or proto-oncogenes, and to some degree are correlated with the prognosis of HCC ...
Guangyan Zhangyuan, Yin Yin, Wenjie Zhang, WeiWei Yu, Kangpeng Jin, Fei Wang, Ruyi Huang, Haiyuan Shen, Xiaochen Wang, Beicheng Sun   +9 more
doaj   +1 more source

Focal adhesion kinase inhibition synergizes with nab-paclitaxel to target pancreatic ductal adenocarcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease, with minimal therapeutic options. Aberrant tyrosine kinase activity influences tumor growth and is regulated by phosphorylation. We investigated phosphorylated kinases as target
T. Y. S. Le Large, M. F. Bijlsma, B. El Hassouni, G. Mantini, T. Lagerweij, A. A. Henneman, N. Funel, B. Kok, T. V. Pham, R. de Haas, L. Morelli, J. C. Knol, S. R. Piersma, G. Kazemier, H. W. M. van Laarhoven, E. Giovannetti, C. R. Jimenez   +16 more
doaj   +1 more source

Divergent AKT Signalling Mechanisms Regulate GLUT4 Translocation and Glucose Uptake in Skeletal Muscle and Adipose Tissue

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background The serine/threonine kinase AKT is a key regulator of glucose and energy metabolism. Prevailing dogma suggests that AKT is an obligate intermediate for glucose uptake in all metabolic tissues and that impaired AKT signalling is a major molecular driver of insulin resistance in obesity.
Natasha Jaiswal, Matthew Gavin, Louise Lantier, Olivia Yu Yu Ong, David H. Wasserman, Paul M. Titchenell   +5 more
wiley   +1 more source

Targeting CD148 for Antithrombotic Therapy: Functional and Molecular Evaluation of AKB‐9778

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT CD148 is the primary receptor‐type protein tyrosine phosphatase (PTP) regulating platelet activation, and its inhibition has been proposed as a novel anti‐thrombotic strategy with potentially lower bleeding risk than current therapies. However, selective and potent inhibitors of CD148 are currently lacking.
Lina El Badaoui, Stipo Jurcevic, Yotis A. Senis, Alastair J. Barr   +3 more
wiley   +1 more source

Phosphotyrosine Confers Client Specificity to Hsp90 [PDF]

Molecular Cell, 2010
In this issue of Molecular Cell, Mollapour et al. (2010) report a new tyrosine phosphorylation site in Hsp90, which is essential for Hsp90's interaction with a subset of its client proteins, notably protein kinases.
openaire   +2 more sources

Identification of Eph receptor signaling as a regulator of autophagy and a therapeutic target in colorectal carcinoma

Molecular Oncology, 2019
Advanced colorectal carcinoma is currently incurable, and new therapies are urgently needed. We report that phosphotyrosine‐dependent Eph receptor signaling sustains colorectal carcinoma cell survival, thereby uncovering a survival pathway active in ...
Michael DiPrima, Dunrui Wang, Alix Tröster, Dragan Maric, Nekane Terrades‐Garcia, Taekyu Ha, Hyeongil Kwak, David Sanchez‐Martin, Denis Kudlinzki, Harald Schwalbe, Giovanna Tosato   +10 more
doaj   +1 more source

Amyloid β Peptide Specifically Promotes Phosphorylation and Nuclear Translocation of the Extracellular Signal-Regulated Kinase in Cultured Rat Cortical Astrocytes

Journal of Pharmacological Sciences, 2003
: To explore cellular signaling molecules that respond to amyloid β protein (Aβ), we investigated the effect of Aβ on tyrosine phosphorylation of cellular proteins in cultured rat cortical astrocytes.
Kazuho Abe, Rie Hisatomi, Miwa Misawa
doaj   +1 more source

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.

Journal of Biological Chemistry, 1993
There are two major isoforms of the angiotensin II receptor, type 1 (AT1) and type 2 (AT2). AT2 is distinguished from AT1 with respect to its ligand selectivity, its insensitivity to non-hydrolyzable GTP analogues, and its as yet unidentified biological ...
Y. Kambayashi, Smriti BardhanS, Kyoko Takahashi, S. Tsuzuki, H. Inui, T. Hamakubo, Tadashi Inagamil   +6 more
semanticscholar   +1 more source