Results 101 to 110 of about 14,467 (226)

Progressive mitochondrial dysfunction impairs visual signal transduction and induces retinal degeneration in Drosophila

open access: yesFrontiers in Insect Science
Mitochondrial dysfunction is closely associated with the pathogenesis of retinitis pigmentosa (RP), often through the generation of reactive oxygen species (ROS), which disrupts visual signal transduction.
Jinguo Cao   +10 more
doaj   +1 more source

Mixed Palettes of Melanopsin Phototransduction [PDF]

open access: yesCell, 2018
Animal photoreceptors divide into two fundamental classes, ciliary and rhabdomeric. Jiang and colleagues demonstrate that this boundary is disregarded by the intrinsically photosensitive retinal ganglion cells of mammals. These neurons draw from phototransduction mechanisms of both classes, enriching the signals that they produce to drive a diversity ...
openaire   +2 more sources

Widespread Variation in Retinochrome Spectral Absorbance Across Scallop Phylogeny

open access: yesMolecular Ecology, Volume 35, Issue 11, June 2026.
ABSTRACT Vision is a two‐step process, including phototransduction initiated by a retinal‐bound opsin photopigment, and subsequent photopigment regeneration wherein the inactive state is restored. Because retinal isomerization, or changing of the molecular structural conformation, drives the activation of opsin photopigments, the reverse process is a ...
Kyle E. McElroy   +3 more
wiley   +1 more source

Towards a unified model of verebrate rod phototransduction

open access: yes, 2015
Recently, we introduced a phototransduction model that was able to account for the reproducibility of vertebrate rod single-photon responses (SPRs) (Hamer et al., 2003).
Hamer, Russell D   +4 more
core   +1 more source

Inherited macular degeneration-associated mutations in CNGB3 increase the ligand sensitivity and spontaneous open probability of cone cyclic nucleotide-gated channels.

open access: yesFrontiers in Physiology, 2015
Cyclic nucleotide gated (CNG) channels are a critical component of the visual transduction cascade in the vertebrate retina. Mutations in the genes encoding these channels have been associated with a spectrum of inherited retinal disorders.
Peter eMeighan   +2 more
doaj   +1 more source

Dual Knockout Models of the Spatially and Functionally Conserved rgra and rgrb Zebrafish Genes Reveal the Requirement of RGR for the Integrity of Cone‐Mediated Photopic Vision, the Photopic Visual Cycle and Bruch's Membrane Morphology

open access: yesThe FASEB Journal, Volume 40, Issue 10, 31 May 2026.
This study investigates the role of the vision gene RGR using novel dual knockout zebrafish models. The loss of rgra and rgrb results in zebrafish larvae having reduced visual function and altered retinoid profiles under light but not dark conditions. The OKR phenotype is enhanced under higher light intensities.
Grace Ruddin   +13 more
wiley   +1 more source

The Role of Adenylate Cyclase in Hydra Magnipapillata Phototransduction

open access: yes, 2017
Cnidarians are members of an early branching phylum of animals with unexpectedly complex sensory capable of detecting light, chemical, and mechanical stimuli despite lacking the specialized sensory organs that bilaterian animals commonly possess ...
Chan, Jonathan
core  

Phototransduction: Keep an Eye Out for Acid-Labile TRPs

open access: yes, 2010
SummaryOur mechanistic understanding of phototransduction in the Drosophila eye is still rudimentary. Recent work demonstrates that a combination of phosphoinositide depletion and microvillar acidification is sufficient to activate light-sensitive TRPC ...
Mederos y Schnitzler, Michael   +1 more
core   +1 more source

Phototransduction: Shedding Light on Translocation [PDF]

open access: yesCurrent Biology, 2003
Light induces the migration of arrestin to the photosensitive membrane in both vertebrate and invertebrate photoreceptors. New work has identified a phosphoinositide lipid binding domain in Drosophila arrestin and implicates PIP(3) in control of arrestin translocation.
openaire   +2 more sources

Functional genomics identifies regulators of the phototransduction machinery in the Drosophila larval eye and adult ocelli

open access: yes, 2016
Sensory perception of light is mediated by specialized Photoreceptor neurons (PRs) in the eye. During development all PRs are genetically determined to express a specific Rhodopsin (Rh) gene and genes mediating a functional phototransduction pathway ...
Mishra, Abhishek Kumar   +4 more
core   +1 more source

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