Results 31 to 40 of about 3,532 (155)

Glutamatergic Neurotransmission at Rat Phrenic Motor Neurons

The FASEB Journal, 2020
Glutamatergic (Glu) synaptic inputs at phrenic motor neurons (PhMNs) predominantly comprise descending axons from respiratory centers in the ventrolateral medulla. Descending synaptic inputs provide the drive for inspiratory as well as various other behaviors that result in higher force ...
Carlos B. Mantilla, Sabhya Rana, Wen-Zhi Zhan, Gary C. Sieck   +3 more
openaire   +1 more source

Deregulation of ZPR1 causes respiratory failure in spinal muscular atrophy

Scientific Reports, 2017
Spinal muscular atrophy (SMA) is caused by the low levels of survival motor neuron (SMN) protein and is characterized by motor neuron degeneration and muscle atrophy.
Naresh K. Genabai, Annapoorna Kannan, Saif Ahmad, Xiaoting Jiang, Kanchan Bhatia, Laxman Gangwani   +5 more
doaj   +1 more source

Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS

Neurobiology of Disease, 2006
The transgenic mutant superoxide dismutase (SOD1) mice and rats have been important tools in attempting to understand motor neuron pathology and degeneration but the mechanism behind death in this model has not been studied.
Jerònia Lladó, Christine Haenggeli, Andrea Pardo, Victor Wong, Leah Benson, Carol Coccia, Jeffrey D. Rothstein, Jeremy M. Shefner, Nicholas J. Maragakis   +8 more
doaj   +1 more source

Is Innervation of the Neuromuscular Junction at the Diaphragm Modulated by sGC/cGMP Signaling?

Frontiers in Physiology, 2020
We previously reported NO/sGC signaling in the upper respiratory pathway, receiving input from the respiratory neurons of the brainstem to phrenic motoneurons in the C3–C6 spinal cord. In order to assess whether innervation of the neuromuscular junction (
Nadežda Lukáčová, L’udmila Hricová, Alexandra Kisucká, Štefánia Papcunová, Katarína Bimbová, Mária Bačová, Jaroslav Pavel, Martin Marsala, Martin Marsala, Ivo Vanický, Zuzana Dzurjašková, Stanislav Matéffy, Viktória Lukáčová, Andrea Stropkovská, Ján Gálik   +14 more
doaj   +1 more source

Activation of orexin-2 receptors in the Kӧlliker-Fuse nucleus of anesthetized mice leads to transient slowing of respiratory rate

Frontiers in Physiology, 2022
Orexins are neuropeptides originating from the hypothalamus that serve broad physiological roles, including the regulation of autonomic function, sleep-wake states, arousal and breathing.
Adrienn G. Varga, Adrienn G. Varga, Jessica R. Whitaker-Fornek, Jessica R. Whitaker-Fornek, Sebastian N. Maletz, Erica S. Levitt, Erica S. Levitt   +6 more
doaj   +1 more source

Atypical protein kinase C expression in phrenic motor neurons of the rat. [PDF]

Neuroscience, 2010
Atypical protein kinase C (PKC) isoforms play important roles in many neural processes, including synaptic plasticity and neurodegenerative diseases. Although atypical PKCs are expressed throughout the brain, there are no reports concerning their expression in central neural regions associated with respiratory motor control.
Guenther CH, Vinit S, Windelborn JA, Behan M, Mitchell GS.   +4 more
europepmc   +4 more sources

Sonographic Phrenic Nerve Changes in Amyotrophic Lateral Sclerosis

Medicina, 2023
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects both the upper and lower motor neurons in the nervous system, causing muscle weakness and severe disability.
Ovidijus Laucius, Justinas Drūteika, Renata Balnytė, Kęstutis Petrikonis, Miglė Ališauskienė, Antanas Vaitkus   +5 more
doaj   +1 more source

Teashirt 1 (Tshz1) is essential for the development, survival and function of hypoglossal and phrenic motor neurons in mouse. [PDF]

Development, 2019
Breathing and feeding are essential motor functions and rely on the activity of hypoglossal and phrenic motor neurons that innervate the tongue and diaphragm, respectively. Little is known about the genetic programs that control the development of these neuronal subtypes.
Chaimowicz C, Ruffault PL, Chéret C, Woehler A, Zampieri N, Fortin G, Garratt AN, Birchmeier C.   +7 more
europepmc   +3 more sources

Phrenic Motor Neuron Survival Caudal to C2 Hemisection

The FASEB Journal, 2017
Cervical spinal injury (cSCI) severs descending brainstem projections to spinal respiratory motor neurons, paralyzing respiratory muscles caudal to injury. Spinal hemisection at C2 (C2Hx) has frequently been used as an experimental model of cSCI to study both spontaneous and induced functional recovery of both respiratory and non‐respiratory somatic ...
Latoya Lynn Allen, Juliet V Santiago, Zachary A Asa, Ashley E Holland, Marissa Ciesla, Irawan S Satriotomo, Gordon S Mitchell, Elisa Janine Gonzalez‐Rothi   +7 more
openaire   +1 more source

Phrenic motor neuron loss in an animal model of early onset hypertonia

Journal of Neurophysiology, 2020
Phrenic motor neuron (PhMN) development in early onset hypertonia is poorly understood. Yet, respiratory disorders are a common cause of morbidity and mortality. In spa mice, an animal model of early onset hypertonia, we found ~30% fewer PhMNs, compared with controls. This PhMN loss disproportionately affected larger PhMNs.
Joline E. Brandenburg, Matthew J. Fogarty, Alyssa D. Brown, Gary C. Sieck   +3 more
openaire   +6 more sources