Results 11 to 20 of about 3,532 (155)

Decreased spinal synaptic inputs to phrenic motor neurons elicit localized inactivity-induced phrenic motor facilitation [PDF]

Experimental Neurology, 2014
Phrenic motor neurons receive rhythmic synaptic inputs throughout life. Since even brief disruption in phrenic neural activity is detrimental to life, on-going neural activity may play a key role in shaping phrenic motor output. To test the hypothesis that spinal mechanisms sense and respond to reduced phrenic activity, anesthetized, ventilated rats ...
Streeter KA, Baker-Herman TL.
exaly   +5 more sources

Inactivity-induced phrenic motor facilitation requires PKCζ activity within phrenic motor neurons

Journal of Neurophysiology
We report important new findings concerning the mechanisms regulating a form of spinal neuroplasticity elicited by prolonged inhibition of respiratory neural activity, inactivity-induced phrenic motor facilitation (iPMF). We demonstrate that the atypical PKC isoform PKCζ within phrenic motor neurons is necessary for long-lasting iPMF, whereas ...
Nathan A Baertsch, Alexandria B Marciante, Gordon S Mitchell   +2 more
exaly   +4 more sources

Postnatal survival of phrenic motor neurons is promoted by BDNF/TrkB.FL signaling

Journal of Applied Physiology
During early postnatal development, BDNF/TrkB signaling promotes PhMN survival. Inhibition of BDNF/TrkB signaling in early postnatal development does not impact PhMN size. Inhibition of BDNF/TrkB signaling in early postnatal development does not impact the number or CSA of DIAm fibers.
Joline E Brandenburg, Matthew J Fogarty, Wen-Zhi Zhan   +2 more
exaly   +4 more sources

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

Communications Biology
The fatal motor neuron (MN) disease Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive MN degeneration. Phrenic MNs (phMNs) controlling the activity of the diaphragm are prone to degeneration in ALS, leading to death by respiratory ...
Louise Thiry, Julien Sirois, Thomas M. Durcan, Stefano Stifani   +3 more
doaj   +4 more sources

Retrograde Neuroanatomical Tracing of Phrenic Motor Neurons in Mice. [PDF]

J Vis Exp, 2018
Phrenic motor neurons are cervical motor neurons originating from C3 to C6 levels in most mammalian species. Axonal projections converge into phrenic nerves innervating the respiratory diaphragm. In spinal cord slices, phrenic motor neurons cannot be identified from other motor neurons on morphological or biochemical criteria.
Vandeweerd JM, Hontoir F, De Knoop A, De Swert K, Nicaise C.   +4 more
europepmc   +5 more sources

Functional and morphological assessment of diaphragm innervation by phrenic motor neurons. [PDF]

J Vis Exp, 2015
This protocol specifically focuses on tools for assessing phrenic motor neuron (PhMN) innervation of the diaphragm at both the electrophysiological and morphological levels. Compound muscle action potential (CMAP) recording following phrenic nerve stimulation can be used to quantitatively assess functional diaphragm innervation by PhMNs of the cervical
Martin M, Li K, Wright MC, Lepore AC.
europepmc   +4 more sources

Size-dependent differences in mitochondrial volume density in phrenic motor neurons.

J Appl Physiol (1985), 2023
Type S and FR motor units, comprising smaller phrenic motor neurons (PhMNs) are regularly activated to perform indefatigable ventilatory requirements. By contrast, type FF motor units, comprising larger PhMNs, are infrequently activated to perform expulsive straining and airway defense maneuvers.
Fogarty MJ, Rana S, Mantilla CB, Sieck GC.   +3 more
europepmc   +3 more sources

Coordinated cadherin functions sculpt respiratory motor circuit connectivity

eLife, 2022
Breathing, and the motor circuits that control it, is essential for life. At the core of respiratory circuits are Dbx1-derived interneurons, which generate the rhythm and pattern of breathing, and phrenic motor neurons (MNs), which provide the final ...
Alicia N Vagnozzi, Matthew T Moore, Minshan Lin, Elyse M Brozost, Ritesh KC, Aambar Agarwal, Lindsay A Schwarz, Xin Duan, Niccolò Zampieri, Lynn T Landmesser, Polyxeni Philippidou   +10 more
doaj   +1 more source

Phrenic motor neuron loss in aged rats [PDF]

Journal of Neurophysiology, 2018
Sarcopenia is the age-related reduction of muscle mass and specific force. In previous studies, we found that sarcopenia of the diaphragm muscle (DIAm) is evident by 24 mo of age in both rats and mice and is associated with selective atrophy of type IIx and IIb muscle fibers and a decrease in maximum specific force. These fiber type-specific effects of
Fogarty, Matthew J., Omar, Tanya S, Zhan, Wen-Zhi, Mantilla, Carlos B., Sieck, Gary C.   +4 more
openaire   +5 more sources

Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7

Disease Models & Mechanisms, 2021
Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion in the coding region of the ataxin-7 gene.
Anna F. Fusco, Logan A. Pucci, Pawel M. Switonski, Debolina D. Biswas, Angela L. McCall, Amanda F. Kahn, Justin S. Dhindsa, Laura M. Strickland, Albert R. La Spada, Mai K. ElMallah   +9 more
doaj   +1 more source