Results 21 to 30 of about 3,532 (155)
Trophic factor expression in phrenic motor neurons. [PDF]
Respir Physiol Neurobiol, 2008 The function of a motor neuron and the muscle fibers it innervates (i.e., a motor unit) determines neuromotor output. Unlike other skeletal muscles, respiratory muscles (e.g., the diaphragm, DIAm) must function from birth onwards in sustaining ventilation.
Mantilla CB, Sieck GC.
europepmc +4 more sources
Frontiers in Physiology, 2021 Moderate acute intermittent hypoxia (mAIH) elicits a progressive increase in phrenic motor output lasting hours post-mAIH, a form of respiratory motor plasticity known as phrenic long-term facilitation (pLTF). mAIH-induced pLTF is initiated by activation
Raphael R. Perim +3 more
doaj +1 more source
Central Nervous System Involvement in Chronic Obstructive Pulmonary Disease
The Iraqi Journal of Medical Sciences, 2023 Background: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous disease. Studies evaluating both peripheral and central nervous system involvement in patients with COPD at the same time are rare.
Jumana Kareem +2 more
doaj +1 more source
Genetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development. [PDF]
PLoS ONE, 2013 Central nervous system GABAergic and glycinergic synaptic activity switches from postsynaptic excitation to inhibition during the stage when motor neuron numbers are being reduced, and when synaptic connections are being established onto and by motor ...
Matthew J Fogarty +5 more
doaj +1 more source
Phrenic-specific transcriptional programs shape respiratory motor output
eLife, 2020 The precise pattern of motor neuron (MN) activation is essential for the execution of motor actions; however, the molecular mechanisms that give rise to specific patterns of MN activity are largely unknown.
Alicia N Vagnozzi +8 more
doaj +1 more source
Journal of Neuroinflammation, 2021 Background Inflammation undermines multiple forms of neuroplasticity. Although inflammation and its influence on plasticity in multiple neural systems has been extensively studied, its effects on plasticity of neural networks controlling vital life ...
Arash Tadjalli +3 more
doaj +1 more source
Morphological characterization of spinal respiratory phrenic motoneurons
Di-san junyi daxue xuebao, 2022 Objective To study the spatial distribution of respiratory-related phrenic motoneurons within the spinal cord and comparison of their distribution characteristics with those of deltoid motoneurons and intercostal motoneurons.
ZHANG Junhong +4 more
doaj +1 more source
Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats
Neurobiology of Disease, 2010 In amyotrophic lateral sclerosis (ALS), the exogenous temporal triggers that result in initial motor neuron death are not understood. Overactivation and consequent accelerated loss of vulnerable motor neurons is one theory of disease initiation.
Angelo C. Lepore +9 more
doaj +1 more source
A Latent Propriospinal Network Can Restore Diaphragm Function after High Cervical Spinal Cord Injury
Cell Reports, 2017 Spinal cord injury (SCI) above cervical level 4 disrupts descending axons from the medulla that innervate phrenic motor neurons, causing permanent paralysis of the diaphragm. Using an ex vivo preparation in neonatal mice, we have identified an excitatory
Jared M. Cregg +9 more
doaj +1 more source
Reconstruction of phrenic neuron identity in embryonic stem cell-derived motor neurons [PDF]
Development, 2014 Air breathing is an essential motor function for vertebrates living on land. The rhythm that drives breathing is generated within the central nervous system and relayed via specialised subsets of spinal motor neurons to muscles that regulate lung volume.
Barcellos Machado, Carolina +10 more
openaire +5 more sources