Results 1 to 10 of about 3,482 (123)

Aging affects the number and morphological heterogeneity of rat phrenic motor neurons and phrenic motor axons [PDF]

Physiological Reports, 2023
Diaphragm muscle (DIAm) motor units comprise a phrenic motor neuron (PhMN), the phrenic nerve and the muscle fibers innervated, with the size of PhMNs and axons characteristic of motor unit type.
Matthew J. Fogarty, Gary C. Sieck
doaj   +3 more sources

Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window

Frontiers in Neural Circuits, 2023
Phrenic Motor Column (PMC) neurons are a specialized subset of motor neurons (MNs) that provide the only motor innervation to the diaphragm muscle and are therefore essential for survival.
Alicia N. Vagnozzi, Matthew T. Moore, Raquel López de Boer, Aambar Agarwal, Niccolò Zampieri, Lynn T. Landmesser, Polyxeni Philippidou   +6 more
doaj   +3 more sources

The evidence for old age motor neuron death: A scoping review. [PDF]

Physiol Rep
We systematically evaluated the extant literature on age‐related motor neuron (MN) death in aging, focusing on studies directly assessing MNs. We show that in the spinal cord and brainstem, there is robust evidence for MN loss, particularly in the human spinal cord. In rats, MN loss was readily observed across a variety of labelling methods and regions,
Cheung SW, Fogarty MJ.
europepmc   +2 more sources

Derivation and Culture of Enriched Phrenic-Like Motor Neurons From Human iPSCs [PDF]

Bio-Protocol
The fatal motor neuron (MN) disease amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of the phrenic MNs (phMNs) controlling the activity of the diaphragm, leading to death by respiratory failure.
Louise Thiry, Julien Sirois, Thomas Durcan, Stefano Stifani   +3 more
doaj   +2 more sources

A cholinergic spinal pathway for the adaptive control of breathing [PDF]

Cell Reports
Summary: The ability to amplify motor neuron (MN) output is essential for generating high-intensity motor actions. This is critical for breathing that must be rapidly adjusted to accommodate changing metabolic demands.
Minshan Lin, Giulia Benedetta Calabrese, Anthony V. Incognito, Matthew T. Moore, Aambar Agarwal, Richard J.A. Wilson, Laskaro Zagoraiou, Simon A. Sharples, Gareth B. Miles, Polyxeni Philippidou   +9 more
doaj   +2 more sources

Disproportionate loss of excitatory inputs to smaller phrenic motor neurons following cervical spinal hemisection [PDF]

Journal of Physiology, 2020
Sabhya Rana, Wen-Zhi Zhan, CARLOS B Mantilla   +2 more
exaly   +2 more sources

Quantifying mitochondrial volume density in phrenic motor neurons [PDF]

Journal of Neuroscience Methods, 2021
Matthew J Fogarty, Sabhya Rana, CARLOS B Mantilla   +2 more
exaly   +2 more sources

Heterogeneous glutamatergic receptor mRNA expression across phrenic motor neurons in rats [PDF]

Journal of Neurochemistry, 2020
Sabhya Rana, Gary C Sieck, CARLOS B Mantilla   +2 more
exaly   +2 more sources

Adenosine 2A receptor inhibition protects phrenic motor neurons from cell death induced by protein synthesis inhibition [PDF]

Experimental Neurology, 2020
Yasin B Seven, Irawan Satriotomo, Gordon S Mitchell   +2 more
exaly   +2 more sources

Phrenic Long-Term Facilitation Requires PKCθ Activity within Phrenic Motor Neurons [PDF]

Journal of Neuroscience, 2015
Daryl P Fields, Adrianne G Huxtable, Timothy J Peterson   +2 more
exaly   +2 more sources