Results 41 to 50 of about 3,532 (155)

Microglia regulate motor neuron plasticity via reciprocal fractalkine and adenosine signaling

Nature Communications
We report an important role for microglia in regulating neuroplasticity within phrenic motor neurons. Brief episodes of low oxygen (acute intermittent hypoxia; AIH) elicit a form of respiratory motor plasticity known as phrenic long-term facilitation ...
Alexandria B. Marciante, Arash Tadjalli, Maria Nikodemova, Kayla A. Burrowes, Jose Oberto, Edward K. Luca, Yasin B. Seven, Jyoti J. Watters, Tracy L. Baker, Gordon S. Mitchell   +9 more
doaj   +1 more source

Spinal TNF-α receptor 1 is differentially required for phrenic long-term facilitation (pLTF) over the course of motor neuron death in adult rats

Frontiers in Physiology
IntroductionIntrapleural injections of cholera toxin B conjugated to saporin (CTB-SAP) result in selective respiratory (e.g., phrenic) motor neuron death and mimics aspects of motor neuron disease [(e.g., amyotrophic lateral sclerosis (ALS) and spinal ...
Ryan D. Lewis, Amy N. Keilholz, Amy N. Keilholz, Catherine L. Smith, Ethan A. Burd, Nicole L. Nichols, Nicole L. Nichols, Nicole L. Nichols   +7 more
doaj   +1 more source

Segmental composition and nerve distribution of the brachial plexus in Galictis cuja

The Anatomical Record, EarlyView.
Abstract Galictis cuja is a neotropical mustelid with terrestrial locomotor habits, yet the anatomy of its brachial plexus has remained undescribed. This study characterizes the origin, organization, and distribution of the brachial plexus nerves in 15 adult specimens (30 antimeres).
Natan da Cruz de Carvalho, Thais Mattos Estruc, Ingrid Bete Palmeira, Julia Fagundes Franco, Emillin Reis Bermudez, Paulo de Souza‐Junior, Marcelo Abidu‐Figueiredo   +6 more
wiley   +1 more source

Phrenic motor neuron TrkB expression is necessary for acute intermittent hypoxia-induced phrenic long-term facilitation [PDF]

Experimental Neurology, 2017
Phrenic long-term facilitation (pLTF) is a form of hypoxia-induced spinal respiratory motor plasticity that requires new synthesis of brain derived neurotrophic factor (BDNF) and activation of its high-affinity receptor, tropomyosin receptor kinase B (TrkB).
Erica A, Dale, Daryl P, Fields, Michael J, Devinney, Gordon S, Mitchell   +3 more
openaire   +2 more sources

Circadian clock protein Bmal1 regulates respiratory motor plasticity in male rats

Function
Acute intermittent hypoxia (AIH) elicits respiratory motor plasticity in the phrenic, intercostal, and hypoglossal motor pools and has emerged as a promising therapeutic strategy to improve respiratory function in people with neuromuscular disorders that
Aaron A. Jones, Alexandria B. Marciante, Pierce Berardi, Gordon S. Mitchell   +3 more
doaj   +1 more source

Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons

eLife, 2013
Disruption of the Frizzled3 (Fz3) gene leads to defects in axonal growth in the VIIth and XIIth cranial motor nerves, the phrenic nerve, and the dorsal motor nerve in fore- and hindlimbs.
Zhong L Hua, Philip M Smallwood, Jeremy Nathans   +2 more
doaj   +1 more source

Donor‐To‐Recipient Mean Axonal Count Ratios of Upper Limb Nerves Used in Nerve Transfer Surgery: A Systematic Review of Histomorphometric Cadaveric Studies

Clinical Anatomy, EarlyView.
ABSTRACT Nerve transfer surgery may be performed to restore sensorimotor function following peripheral nerve trauma or dysfunction. There is biological plausibility and limited correlative evidence that donor‐to‐recipient axon count ratios may impact functional outcomes.
Samuel James Ng, Rosa Morgan‐Young, Alexander Laing, Rebecca Molden, Suzanne Thomson   +4 more
wiley   +1 more source

Intralingual and Intrapleural AAV Gene Therapy Prolongs Survival in a SOD1 ALS Mouse Model

Molecular Therapy: Methods & Clinical Development, 2020
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results in death from respiratory failure. No cure exists for this devastating disease, but therapy that directly targets the respiratory system has the potential to prolong ...
Allison M. Keeler, Marina Zieger, Carson Semple, Logan Pucci, Alessandra Veinbachs, Robert H. Brown, Jr., Christian Mueller, Mai K. ElMallah   +7 more
doaj   +1 more source

Interdisciplinary approaches of transcranial magnetic stimulation applied to a respiratory neuronal circuitry model. [PDF]

PLoS ONE, 2014
Respiratory related diseases associated with the neuronal control of breathing represent life-threatening issues and to date, no effective therapeutics are available to enhance the impaired function.
Stéphane Vinit, Emilie Keomani, Thérèse B Deramaudt, Victoria M Spruance, Tatiana Bezdudnaya, Michael A Lane, Marcel Bonay, Michel Petitjean   +7 more
doaj   +1 more source

Respiratory axon regeneration in the chronically injured spinal cord

Neurobiology of Disease, 2021
Promoting the combination of robust regeneration of damaged axons and synaptic reconnection of these growing axon populations with appropriate neuronal targets represents a major therapeutic goal following spinal cord injury (SCI).
Lan Cheng, Armin Sami, Biswarup Ghosh, Hannah J. Goudsward, George M. Smith, Megan C. Wright, Shuxin Li, Angelo C. Lepore   +7 more
doaj   +1 more source