Results 121 to 130 of about 912,472 (266)

Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion

Transplantation Direct
Background. Ex vivo normothermic perfusion (EVNP) allows for comprehensive functional assessment; however, current scoring systems are validated only for short perfusion durations.
Enrique Montagud-Marrahi, MD, PhD, Thomas Prudhomme, MD, PhD, Tarek Ajami, MD, Cristina García-Parejo, MD, Lluis Peri, MD, PhD, Adriana Rodriguez-Gonzalo, BSc, Yosu Luque, MD, PhD, Antoni Vilaseca, MD, PhD, Ruben Rabadan-Ros, PhD, Elena Cuadrado-Payan, MD, Elisenda Bañón-Maneus, PhD, Jordi Rovira, PhD, Maria José Ramírez-Bajo, PhD, Lourdes Mengual, PhD, Mercedes Ingelmo, PhD, Ana Belén Larque, MD, PhD, Antonio Alcaraz, MD, PhD, Josep M. Campistol, MD, PhD, Fritz Diekmann, MD, PhD, Mireia Musquera, MD, PhD   +19 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

P633: ACTIVE CHROMATIN REGULATORY LANDSCAPE OF STEREOTYPED SUBSETS IN CHRONIC LYMPHOCYTIC LEUKEMIA REVEALS A DISTINCTIVE SIGNATURE IN SUBSET #8

HemaSphere, 2022
M. Tsagiopoulou, V. Chapaprieta, N. Russiñol, N. Pechlivanis, N. Papakonstantinou, N. Stavroyianni, F. Psomopoulos, E. Campo, K. Stamatopoulos, J. I. Martin-Subero   +9 more
doaj   +1 more source

Glutathione S-transferase Pi 1 is a valuable predictor for cancer drug resistance in esophageal squamous cell carcinoma. [PDF]

Cancer Sci, 2019
Ogino S, Konishi H, Ichikawa D, Matsubara D, Shoda K, Arita T, Kosuga T, Komatsu S, Shiozaki A, Okamoto K, Kishimoto M, Otsuji E.   +11 more
europepmc   +1 more source

Transformation groups on a $K(\pi ,\,1)$. I.

Michigan Mathematical Journal, 1959
Conner, P. E., Montgomery, D.
openaire   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Alpha-1 antitrypsin Pi*Z gene frequency and Pi*ZZ genotype numbers worldwide: an update

International Journal of COPD, 2017
Ignacio Blanco,1 Patricia Bueno,2 Isidro Diego,3 Sergio Pérez-Holanda,4 Francisco Casas-Maldonado,5 Cristina Esquinas,6 Marc Miravitlles6,7 1Alpha1-Antitrypsin Deficiency Spanish Registry (REDAAT), Fundación Respira, Spanish Society of ...
Blanco I, Bueno P, Diego I, Pérez-Holanda S, Casas-Maldonado F, Esquinas C, Miravitlles M   +6 more
doaj  

Evaluation of glutathione S-transferase pi 1 expression and gene promoter methylation in Moroccan patients with urothelial bladder cancer. [PDF]

Mol Genet Genomic Med, 2018
Hadami K, Dakka N, Bensaid M, El Ahanidi H, Ameur A, Chahdi H, Oukabli M, Al Bouzidi A, Attaleb M, El Mzibri M.   +9 more
europepmc   +1 more source