Results 51 to 60 of about 626,720 (343)
Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats [PDF]
, 2009 In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and ...
Giusto, Norma Maria +2 more
core +2 more sources
Endocrine Regulations, 2019 Objective. Ghrelin, a 28 amino acid peptide, has diverse physiological roles. Phosphatidylino-sitol-bisphosphate 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) are involved in some of the recognized actions of ghrelin. It has been shown that
Taherkhani Shokoufeh +4 more
doaj +1 more source
Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology
Biomolecules, 2019 The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily ...
Cristina Sánchez-de-Diego +4 more
doaj +1 more source
1,3,5-triazines inhibit osteosarcoma and avert lung metastasis in a patient-derived orthotopic xenograft mouse model with favorable pharmacokinetics [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Osteosarcoma is a major solid malignant tumor of bone, possessing significant burden on healthcare due to non-availability of specific anticancer agents.
Qing Su +3 more
doaj +1 more source
Focal adhesion kinase-regulated signaling events in human cancer
Biomolecular Concepts, 2012 Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase that is highly expressed or activated in many human cancers. Under specific scenarios, FAK can regulate cell proliferation, cell survival, cell migration and invasion, and has been ...
Fu Wei +2 more
doaj +1 more source
The Mechanisms Underlying PTEN Loss in Human Tumors Suggest Potential Therapeutic Opportunities
Biomolecules, 2019 In this review, we will first briefly describe the diverse molecular mechanisms associated with PTEN loss of function in cancer. We will then proceed to discuss the molecular mechanisms linking PTEN loss to PI3K activation and demonstrate how these ...
Hyeyoun Chang +2 more
doaj +1 more source
Disease Models & Mechanisms, 2021 Activating PIK3CA mutations are known ‘drivers’ of human cancer and developmental overgrowth syndromes. We recently demonstrated that the ‘hotspot’ PIK3CAH1047R variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem
Ralitsa R. Madsen +10 more
doaj +1 more source
The recruitment and activation of phosphatidylinositol 4-phosphate 5-kinases α critically regulate CD28-dependent signaling responses [PDF]
, 2013 CD28 costimulatory receptor is a crucial determinant of the outcome of T lymphocyte activation. The engagement of CD28 by its natural ligands, B7.1/CD80 or B7.2/CD86, expressed on the surface of professional APC, lowers T cell receptor (TCR) activation ...
Camperio, Cristina +6 more
core +1 more source
Recent Advances in Dual PI3K/mTOR Inhibitors for Tumour Treatment
Frontiers in Pharmacology, 2022 The PI3K-Akt-mTOR pathway is a viable target for cancer treatment and can be used to treat various malignant tumours, including follicular lymphoma and breast cancer. Both enzymes, PI3K and mTOR, are critical in this pathway.
Xianbo Wu +7 more
semanticscholar +1 more source
Translational Neuroscience, 2021 Owing to neurite promoting, antioxidant and anti-inflammatory effects of Euxanthone (Eux), the investigation was aimed to probe the neuroprotective efficacy of Eux against traumatic spinal cord injury (t-SCI) in rats and whether Eux can improve ...
Yao Rubin +4 more
doaj +1 more source