Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu +4 more
wiley +1 more source
PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes. [PDF]
J Cell Biol, 2023 Pacheco J +4 more
europepmc +1 more source
The Polarized Redistribution of the Contractile Vacuole to the Rear of the Cell is Critical for Streaming and is Regulated by PI(4,5)P2-Mediated Exocytosis. [PDF]
Front Cell Dev Biol, 2021 Fadil SA, Janetopoulos C.
europepmc +1 more source
Study of the cell biological role of Lowe Syndrome protein OCRL1 [PDF]
, 2009 Oculocerebrorenal syndrome of Lowe (OCRL) is caused by mutations in a phosphatidylinositol 5-phosphatase, OCRL1, and is believed to lead to an elevation of its preferred substrate, PI(4,5)P2.
Grieve, A.G.
core
A novel homeostatic mechanism tunes PI(4,5)P2-dependent signaling at the plasma membrane.
J Cell Sci, 2023 Wills RC +5 more
europepmc +1 more source
A Plethora of Functions Condensed into Tiny Phospholipids: The Story of PI4P and PI(4,5)P2. [PDF]
Cells, 2023 Bura A +4 more
europepmc +1 more source
Nature CommunicationsIn plants, the developing cell plate which is characterized by a series of anionic lipids, undergoes dramatic morphological change for successful cytokinesis.
Yu Luo +3 more
doaj +1 more source
Rezeptorinduzierte PI(4,5)P2-Dynamik in hippocampalen CA1-Pyramidenneuronen
, 2014 Das Plasmamembranlipid Phosphatidylinositol(4,5)biphosphat (PIP2) ist an der Regulation einer Vielzahl zellularer Prozesse beteiligt. Die Dynamik der PIP2-Konzentration in lebenden Zellen in ihrer nativen Umgebung ist bislang allerdings weitgehend unerforscht.
openaire +2 more sources
Noncanonical PI(4,5)P2 coordinates lysosome positioning through cholesterol trafficking
AbstractIn p53-deficient cancers, targeting cholesterol metabolism has emerged as a promising therapeutic approach, given that p53 loss dysregulates sterol regulatory element-binding protein 2 (SREBP-2) pathways, thereby enhancing cholesterol biosynthesis. While cholesterol synthesis inhibitors such as statins have shown initial success, their efficacy
Ryan M. Loughran +8 more
openaire +1 more source
A conserved PI(4,5)P2-binding domain is critical for immune regulatory function of DOCK8. [PDF]
Life Sci Alliance, 2021 Sakurai T +10 more
europepmc +1 more source