Results 51 to 60 of about 64,413 (204)

Structural organization and dynamics of FCHo2 docking on membranes

eLife, 2022
Clathrin-mediated endocytosis (CME) is a central trafficking pathway in eukaryotic cells regulated by phosphoinositides. The plasma membrane phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays an instrumental role in driving CME initiation. The F-BAR
Fatima El Alaoui, Ignacio Casuso, David Sanchez-Fuentes, Charlotte Arpin-Andre, Raissa Rathar, Volker Baecker, Anna Castro, Thierry Lorca, Julien Viaud, Stéphane Vassilopoulos, Adrian Carretero-Genevrier, Laura Picas   +11 more
doaj   +1 more source

Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer [PDF]

, 2015
In the absence of extracellular stimulation the adaptor protein growth factor receptor-bound protein (Grb2) and the phospholipase Plcγ1 compete for the same binding site on fibroblast growth factor receptor 2 (FGFR2).
A B Gladden, A Casamayor, A K Sood, AB Turke, AK Mahbub Hasan, B Rotblat, B Vanhaesebroeck, C Cole, C Gauglhofer, C Ivan, C V Kingsley, C Vallien, C-C Lin, DA Altomare, DA Altomare, EF Rodriguez, F Janku, G B Mills, G Lopez-Berestein, G N A Pena, I Vivanco, J Berrout, J Clark, J E Ladbury, J F Hancock, J Liu, J Pan, JA Engelman, JK Ching, K Yang, KH Khan, LM Ooms, M Bogdanov, M Cully, M Gagea, M Mazzoletti, M Ushio-Fukai, M-C Hung, MJ Fry, MS Song, MV Risbud, N Thapa, N Yamamoto, P Storz, R Troncoso, RB Campbell, RE Redfern, RW Tothill, S König, S Pirkmajer, S Srinivasan, SA Byron, TF Franke, X Hu, Y Katoh, Y Lu, Y Matsuda, Y Zhou, Y Zhou, Z Ahmed, Z Ahmed, Z Ahmed, Z Ahmed, Z Timsah, Z Timsah   +64 more
core   +1 more source

The coincidence biosensor tubbyCT reveals local phosphatidylinositol-4,5-bisphosphate synthesis at endoplasmic reticulum-plasma membrane junctions [PDF]

, 2020
Phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays a prominent role in plasma membrane (PM) physiology. It is implicated in the regulation of a variety of cellular functions including exo- and endocytosis, cytoskeleton anchorage, and ion channel ...
Thallmair, Veronika
core   +1 more source

LPS-induced clustering of CD14 triggers generation of PI(4,5)P2 [PDF]

Journal of Cell Science, 2015
Bacterial lipopolysaccharide (LPS) induces strong pro-inflammatory reactions after sequential binding to CD14 protein and TLR4 receptor. Here we show that CD14 controls generation of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] in response to LPS binding. In J774 cells and HEK293 cells expressing CD14 exposed to 10-100 ng/ml LPS, the level of PI(4,
Agnieszka, Płóciennikowska, Mykola I, Zdioruk, Gabriela, Traczyk, Anna, Świątkowska, Katarzyna, Kwiatkowska   +4 more
openaire   +2 more sources

Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring

eLife, 2017
HIV-1 assembles at the plasma membrane (PM) of infected cells. PM association of the main structural protein Gag depends on its myristoylated MA domain and PM PI(4,5)P2. Using a novel chemical biology tool that allows rapidly tunable manipulation of PI(4,
Frauke Mücksch, Vibor Laketa, Barbara Müller, Carsten Schultz, Hans-Georg Kräusslich   +4 more
doaj   +1 more source

Gradients of PI(4,5)P2 and PI(3,5)P2 Jointly Participate in Shaping the Back State of Dictyostelium Cells [PDF]

Frontiers in Cell and Developmental Biology, 2022
Polarity, which refers to the molecular or structural asymmetry in cells, is essential for diverse cellular functions. Dictyostelium has proven to be a valuable system for dissecting the molecular mechanisms of cell polarity. Previous studies in Dictyostelium have revealed a range of signaling and cytoskeletal proteins that function at the leading edge
Dong Li, Dong Li, Feifei Sun, Feifei Sun, Yihong Yang, Hui Tu, Hui Tu, Huaqing Cai, Huaqing Cai   +8 more
openaire   +5 more sources

Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector [PDF]

, 2012
Adaptive immunity depends on lymphocyte adhesion that is mediated by the integrin lymphocyte functional antigen 1 (LFA-1). The small guanosine triphosphatase Rap1 regulates LFA-1 adhesiveness through one of its effectors, Rap1-interacting adapter ...
Boussiotis, Vassiliki A., Hubbard, Stevan R., Mor, Adam, Patsoukis, Nikolaos, Philips, Mark R., Su, Wenjuan, Wu, Jinhua, Wynne, Joseph P.   +7 more
core   +2 more sources

Distinct functional properties of two electrogenic isoforms of the SLC34 Na‐Pi cotransporter

Physiological Reports, 2019
Inorganic phosphate (Pi) is crucial for proper cellular function in all organisms. In mammals, type II Na‐Pi cotransporters encoded by members of the Slc34 gene family play major roles in the maintenance of Pi homeostasis.
Natsuki Mizutani, Yoshifumi Okochi, Yasushi Okamura   +2 more
doaj   +1 more source

Quantification of the in-vivo affinity of PI(4,5)P2 effectors and sensors with the phosphoinositide phosphatase Ci-VSP [PDF]

, 2011
Zusammenfassung Quantifizierung der in-vivo Affinität von PI(4,5)P2- Effektoren und Sensoren mit der Phosphoinositidphosphatase Ci-VSP Phosphoinositide (PI) sind Mitglieder einer Familie kleiner Membranphospholipide, die wichtige Aufgaben in vielen ...
Rjasanow, Alexandra
core   +1 more source

Phosphatidylinositol 4-phosphate 5-kinase β regulates growth cone morphology and Semaphorin 3A-triggered growth cone collapse in mouse dorsal root ganglion neurons [PDF]

, 2013
Growth cone motility and morphology, which are critical for axon guidance, are controlled through intracellular events such as actin cytoskeletal reorganization and vesicular trafficking.
Goshima Yoshio, Kanaho Yasunori, Yamauchi Yohei, Yamazaki Masakazu, 金保 安則   +4 more
core   +1 more source