Results 61 to 70 of about 5,000,063 (295)
The Journal of Headache and Pain, 2021 Background Altered glutamatergic neurotransmission and neuropeptide levels play a central role in migraine pathomechanism. Previously, we confirmed that kynurenic acid, an endogenous glutamatergic antagonist, was able to decrease the expression of ...
Bernadett Tuka +9 more
doaj +1 more source
Synthesis of highly functionalized 2,2'-bipyridines by cyclocondensation of β-ketoenamides – scope and limitations [PDF]
, 2016 The scope of a flexible route to unsymmetrically functionalized bipyridines is described. Starting from 1,3-diketones 1a–e, the corresponding β-ketoenamines 2a–e were converted into different β-ketoenamides 3a–g by N-acylation with 2-pyridinecarboxylic ...
Hommes, Paul, Reissig, Hans-Ulrich
core +2 more sources
X-Ray structure and cytotoxic activity of a picolinate ruthenium(II)–arene complex [PDF]
Journal of the Serbian Chemical Society, 2011 A ruthenium(II)–arene complex with picolinic acid, [(η6-p-cymene)RuCl(pico)]∙H2O, was prepared by the reaction of [(η6-p-cymene)RuCl2]2 with picolinic acid in a 1:2 molar ratio in 2-propanol.
IVANKA IVANOVIĆ +6 more
doaj
Reasoned opinion on the modification of the existing MRL for aminopyralid in rape seed [PDF]
EFSA Journal, 2012 <p>In accordance with Article 6 of Regulation (EC) No 396/2005, France, herewith referred to as the evaluating Member State (EMS), received an application from Dow AgroSciences to modify the existing MRL(s) for the active substance aminopyralid in ...
European Food Safety Authority
doaj +1 more source
Sensing a Bacillis anthracis biomarker with well-known OLED emitter EuTta3Phen [PDF]
, 2016 Dipicolinic acid (DPA) is a distinctive biomarker for bacterial spores. Here, we present the successful demonstration of dramatic Switch-OFF sensing of DPA using an easily synthesised Eu(III) phosphor applied primarily in light-emitting devices.
Aspinall +18 more
core +1 more source
Gut Microbiota-derived Bile Acids Promote Gamma-secretase Activity Through Interactions with Nicastrin Subunits [PDF]
arXiv, 2023 Alzheimer's disease (AD) has emerged as a progressively pervasive neurodegenerative disorder worldwide. Bile acids, synthesized in the liver and modified by the gut microbiota, play pivotal roles in diverse physiological processes, and their dysregulation in individuals with AD has been well-documented.
arxiv
A protocol for genetic analysis at different stages of the nuclear division cycle in Neurospora crassa [PDF]
, 2023 The filamentous fungus Neurospora crassa is an organism that contains multiple nuclei in the asexual conidia and hyphae. Since the nuclei of dormant conidia are arrested at various points in the nuclear division cycle, it has been difficult to analyze ...
Shin Hatakeyama +2 more
core +2 more sources
An Alternative Mechanistic Paradigm for the Electrochemical C‐Terminal Decarboxylation of Peptides
ChemElectroChem, EarlyView.Chemoselectivity in electrochemical oxidations is largely influenced by oxidation potential which represents a challenge for selectively oxidizing higher potential functional groups in complex substrates. Herein, a molecular binding strategy that selectively oxidizes the C‐terminal acid of a model peptide containing an electron‐rich tyrosine residue by
Adam J. Sowers +2 more
wiley +1 more source
Symmetry Scheme for Amino Acid Codons [PDF]
Phys.Rev.E65, 021912 (2002), 2003 Group theoretical concepts are invoked in a specific model to explain how only twenty amino acids occur in nature out of a possible sixty four. The methods we use enable us to justify the occurrence of the recently discovered twenty first amino acid selenocysteine, and also enables us to predict the possible existence of two more, as yet undiscovered ...
arxiv +1 more source
ChemMedChem, Accepted Article.We have described the synthesis of a new series of LCAPs (long‐chain arylpiperazine) as serotoninergic ligands (FG 1‐18). The combination of structural elements including heterocyclic nucleus, propyl chain and 4,5‐dihydrothiazol‐2‐ylphenylpiperazines, led to the preparation of different derivatives tested for their affinity toward 5‐HT1A, 5‐HT2A and 5 ...
Giorgia Andreozzi +18 more
wiley +1 more source