Results 51 to 60 of about 5,045,142 (209)

The N‐Bromo‐Hammick Intermediate

Chemistry – A European Journal, EarlyView.
Spectroscopic and computational analysis uncovers the σ2σ*0 electronic structure of the N‐bromo‐Hammick intermediate, a singlet N‐heterocyclic carbene isolated in solid neon, whose back‐isomerization to bromopyridine proceeds via a planar transition state.
Virinder Bhagat, J. Philipp Wagner
wiley   +1 more source

Speciation of metal complexes of medicinal interest: relationship between solution equilibria and pharmaceutical properties [PDF]

, 2018
Biospeciation of essential and toxic metal ions, metal complexes with biological or medicinal activity are discussed in the paper in order to emphasize the importance of the distribution of metal ions in biological milieu.
Dömötör, Orsolya, Enyedy, Éva Anna, Jakusch, Tamás, Kiss, Tamás   +3 more
core   +2 more sources

Pyrazinoic acid, the active form of the anti-tuberculosis drug pyrazinamide, and aromatic carboxylic acid analogs are protonophores

Frontiers in Molecular Biosciences
Pyrazinoic acid is the active form of pyrazinamide, a first-line antibiotic used to treat Mycobacterium tuberculosis infections. However, the mechanism of action of pyrazinoic acid remains a subject of debate, and alternatives to pyrazinamide in cases of
Fabio L. Fontes, Fabio L. Fontes, Steven A. Rooker, Jamie K. Lynn-Barbe, Michael A. Lyons, Debbie C. Crans, Debbie C. Crans, Dean C. Crick, Dean C. Crick   +8 more
doaj   +1 more source

Carboxylic Solvents and O-Donor Ligand Effects on CH Activation by Pt(II) [PDF]

, 2006
We report on the design of more efficient C−H activation catalysts based on DFT calculations. The first examples of well-defined, N,O-donor ligated platinum complexes that are competent for fast C−H activation are detailed.
Goddard, William A., III, Mironov, Oleg A., Oxgaard, Jonas, Periana, Roy A., Young, Kenneth J. H., Ziatdinov, Vadim R.   +5 more
core   +1 more source

ChemInform Abstract: Electrochemical Synthesis of Nicotinic Acid from β‐Picoline.

ChemInform, 1989
Department of Chemistry, Kashmir University, Srinagar-190 006 Manuscript received 18 February 1988, revised 19 May 1988, accepted 8 June 1988 Electrosyathesis or nicotinic acid from -picoline by potentiostatic oxidation is reported. Efficencies of different electrodes are compared by considering changes in concentration of anolyte and substrate ...
P. N. Gupta, G. M. Rather
openaire   +2 more sources

Preparation and diagnosis of new picolinic acid derivatives

Tikrit Journal of Pure Science, 2023
In this study, a new series of heterocyclic rings derived from picolinic acid was prepared. The quaternary reaction of acid hydrazone with chloroacetyl chloride was intended to obtain the azitidine-2-on ring known as beta-lactam and the preparation of the seventh ring of acid hydrazone reaction with the anhydride and phthalic anhydride To obtain a 3.1 ...
Wameed Raad Abd-allah, Khaled Mtani Al – Janabi   +1 more
openaire   +2 more sources

Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l-Pipecolic Acids.

Journal of the American Chemical Society, 2020
Fusaric acid (FA) is a well-known mycotoxin that plays an important role in plant pathology. The biosynthetic gene cluster for FA has been identified, but the biosynthetic pathway remains unclarified.
Y. Hai, Mengbing Chen, Arthur Huang, Yi Tang   +3 more
semanticscholar   +1 more source

Green and Sustainable Chemistry Approaches on Azide‐Based Click Reactions in Polymer Science

Macromolecular Rapid Communications, EarlyView.
Click Chemistry, particularly the azide‐alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry.
Hatice Mutlu, Bercis Pektas, C. Remzi Becer, Azra Kocaarslan   +3 more
wiley   +1 more source

Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines [PDF]

, 2015
2-Substituted N-acyl-piperidine is a widespread and important structural motif, found in approximately 500 currently available structures, and present in nearly 30 pharmaceutically active compounds.
Lanyon-Hogg, T, Magee, AI, Masumoto, N, Ritzefeld, M, Rzepa, HS, Tate, EW   +5 more
core   +3 more sources

Picolinic acid promoted oxidative decarboxylation of phenylsulfinylacetic acid by Cr(VI)

Bulletin of the Chemical Society of Ethiopia, 2016
The kinetics and mechanism of picolinic acid promoted reaction of phenylsulfinylacetic acid (PSAA) with Cr(VI) was carried out in aqueous acetonitrile medium under pseudo first order conditions. The reaction follows Michaelis-Menten type of kinetics with respect to PSAA.
P. Subramaniam, N. T. Selvi
openaire   +4 more sources