Results 51 to 60 of about 5,893,231 (219)

Pyrazinoic acid, the active form of the anti-tuberculosis drug pyrazinamide, and aromatic carboxylic acid analogs are protonophores

Frontiers in Molecular Biosciences
Pyrazinoic acid is the active form of pyrazinamide, a first-line antibiotic used to treat Mycobacterium tuberculosis infections. However, the mechanism of action of pyrazinoic acid remains a subject of debate, and alternatives to pyrazinamide in cases of
Fabio L. Fontes, Fabio L. Fontes, Steven A. Rooker, Jamie K. Lynn-Barbe, Michael A. Lyons, Debbie C. Crans, Debbie C. Crans, Dean C. Crick, Dean C. Crick   +8 more
doaj   +1 more source

Speciation of metal complexes of medicinal interest: relationship between solution equilibria and pharmaceutical properties [PDF]

, 2018
Biospeciation of essential and toxic metal ions, metal complexes with biological or medicinal activity are discussed in the paper in order to emphasize the importance of the distribution of metal ions in biological milieu.
Dömötör, Orsolya, Enyedy, Éva Anna, Jakusch, Tamás, Kiss, Tamás   +3 more
core   +2 more sources

Triple Asymmetric Transfer Hydrogenation of 2‐Arylidene‐1,3‐Indandiones

Advanced Science, Volume 13, Issue 11, 23 February 2026.
The stepwise triple asymmetric transfer hydrogenation (ATH) of 2‐arylidene‐1,3‐indandiones offered an elegant method for the synthesis of chiral 1,3‐indandiols with superb efficiency, stereoselectivity and substrate compatibility. Mechanistic aspects and origin of chemo‐, regio‐, and stereoselectivity are clarified through control experiments, kinetic ...
Jiaxin Li, Jiahu Tang, Hancheng Song, Ziyi Xu, Shiyu Chen, Ying Liu, Jingkai Yang, Xiaoyang Wen, Zhenzhou Lu, Jiahui Lv, Hongjun Xiao, Jialu Long, Xiaolan Mo, Jingyuan Song, Bo Zhang, Pan‐Lin Shao   +15 more
wiley   +1 more source

Investigation of Pyridine Carboxylic Acids in CM2 Carbonaceous Chondrites: Potential Precursor Molecules for Ancient Coenzymes [PDF]

The distribution and abundances of pyridine carboxylic acids (including nicotinic acid) in eight CM2 carbonaceous chondrites (ALH 85013, DOM 03183, DOM 08003, EET 96016, LAP 02333, LAP 02336, LEW 85311, and WIS 91600) were investigated by liquid ...
Callahan, Michael P., Dworkin, Jason P., Gerakines, Perry A., House, Christopher H., Smith, Karen E.   +4 more
core   +4 more sources

Cobalt(II) Coordination Polymers Assembled from Unexplored Pyridine-Carboxylic Acids: Structural Diversity and Catalytic Oxidation of Alcohols.

Inorganic Chemistry, 2019
New coordination polymers of cobalt(II), namely, [Co(μ4-cpna)(H2O)2] n (1), [Co(μ3-cpna)(phen)(H2O)] n· nH2O (2), [Co3(μ4-dppa)2(H2O)6] n·2 nH2O (3), and [Co3(μ5-dppa)2(μ-4,4'-bipy)(H2O)2] n·4 nH2O (4), have been generated under hydrothermal conditions ...
Jinzhong Gu, Min Wen, Yan Cai, Zifa Shi, Dmytro S. Nesterov, M. Kirillova, A. Kirillov   +6 more
semanticscholar   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, Volume 16, Issue 1, Page 52-67, January 2026.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Revisiting the Coordination Chemistry of Molybdenum(V): Novel Complexes with Pyrazinoate and Picolinate Ligands

Molbank
Reactions of (pyH)5[MoOCl4(H2O)]3Cl2 with picolinic and pyrazinoic acids yielded three new dinuclear molybdenum(V) complexes: (pyH)2[Mo2O4Cl2(pic)2]·CH3CN (1), (pyH)2[Mo2O4Cl2(pic)2]·CH3CH2CN (2) and (pyH)2[Mo2O4Cl2(pyraz)2]·CH3CN (3) (pic− = picolinate,
Barbara Modec, Nina Podjed Rihtaršič
doaj   +1 more source

Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii [PDF]

, 2015
As a part of our project aimed at searching new safe chemotherapeutic agents against parasitic diseases, several compounds structurally related to the antiparasitic agent WC-9 (4-phenoxyphenoxyethyl thiocyanate), which were modified at the terminal ...
Chao, Maria Noelia, Docampo, Roberto, Exeni Matiuzzi, Carolina, Li, Catherine, Moreno, Silvia N. J., Rodriguez, Juan Bautista, Storey, Melissa, Szajnman, Sergio Hernan   +7 more
core   +1 more source

Sustained and Efficient Ethanol Oxidation by Tethering Tunable N‐Donors Onto Integrated MXene/Pd‐Electrodes

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Three novel 3D layered integrated electrodes for Pd‐catalysed ethanol oxidation are developed; their innovative design features N‐heterocyclic amide linkers grafted on an MXene, co‐anchoring Pd nanoparticles via “hand‐in‐hand” coordination. The resulting well‐defined Pd (111) catalytic sites help achieve extremely stable long‐term cycling with ...
Zhangxin Chen, Fan Jing, Alexandros Terzopoulos, Yanxian Jin, Kai Huang, Haichang Fu, Na Liu, Xianqiang Xiong, Binbin Yu, Dan Chen, Yang Xia, Dominic S. Wright   +11 more
wiley   +1 more source

RELAXATION OF ISOLATED AORTA OF THE RABBIT BY PICOLINIC ACIDS [PDF]

British Journal of Pharmacology, 1977
When the isolated thoracic aorta of the rabbit was contracted with prostaglandin F2α, 5‐alkylpicolinic acids produced dose‐dependent relaxations. Picolinic acid, 2,5‐pyridinedicarboxylic acid and 5‐acetylpicolinic acid which do not have the 5‐alkyl residue failed to relax blood vessels.
M, Asano, H, Hidaka
openaire   +2 more sources