Results 61 to 70 of about 5,893,231 (219)

Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies [PDF]

, 2016
Vanadium complexes have been previously utilised as potent inhibitors of cysteine based phosphatases (CBPs). Herein, we present the synthesis and characterisation of two new fluorescently labelled vanadyl complexes (14 and 15) with bridged di-picolinic ...
Agostino Cilibrizzi, Anderie, Cirri, Costa Pessoa, Crans, Cuncic, Dyson, Gillian Whyte, Granier, He, Huyer, Inna Guterman, Juliet Collins, Kolmodin, Levina, Li, Lodyga-Chruscinska, Lok Hang Mak, Low, Lu, Lu, Lu, Mak, Makinen, Marina Fedorova, McLauchlan, McLauchlan, Mercey, Nakai, Ostman, Pessoa, Posner, Posner, Ramon Vilar, Robin Leatherbarrow, Rosivatz, Rudiger Woscholski, Sakurai, Salmeen, Schmid, Schmid, Scott, Seale, Thompson, Uto, Vanhaesebroeck, Walker, Wang, Xu, Yuan, Zhang, Zhang   +51 more
core   +1 more source

Mn2+ Bispidine Complexes as Potential Magnetic Resonance Imaging Agents : Noncoordinating Peripheral Functional Groups Affect Structural, Kinetic, and Relaxation Properties

ChemistryEurope, Volume 4, Issue 1, January 2026.
In the family of Mn2+ complexes formed with pentadentate bispidine chelates, functional groups that do not interfere with metal coordination can play a significant role in enhancing kinetic inertness and proton relaxation efficacy. Mn2+ bispidine complexes combine unprecedented kinetic inertness with high relaxivity and are under scrutiny as potential ...
Maryame Sy, Daouda Ndiaye, Hervé Meudal, Loïc J. Charbonnière, Aline M. Nonat, Éva Tóth   +5 more
wiley   +1 more source

Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines [PDF]

, 2015
2-Substituted N-acyl-piperidine is a widespread and important structural motif, found in approximately 500 currently available structures, and present in nearly 30 pharmaceutically active compounds.
Lanyon-Hogg, T, Magee, AI, Masumoto, N, Ritzefeld, M, Rzepa, HS, Tate, EW   +5 more
core   +3 more sources

Isomerization of α‐Pinene Oxide to Trans‐Pinocarveol

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
An operationally simple protocol for the selective isomerization of α‐pinene oxide (APO) to trans‐pinocarveol (TPC) is disclosed, which leverages inexpensive pyridinium‐halide organocatalysts to mitigate competing 1,2‐alkyl shifts. The scalability of this methodology is demonstrated on a decagram scale and catalyst‐recycling is validated through the ...
Emanuel Studer, Johanna Oortmann, Ryan Gilmour   +2 more
wiley   +1 more source

Biosynthesis of Mycotoxin Fusaric Acid and Application of a PLP-Dependent Enzyme for Chemoenzymatic Synthesis of Substituted l-Pipecolic Acids.

Journal of the American Chemical Society, 2020
Fusaric acid (FA) is a well-known mycotoxin that plays an important role in plant pathology. The biosynthetic gene cluster for FA has been identified, but the biosynthetic pathway remains unclarified.
Y. Hai, Mengbing Chen, Arthur Huang, Yi Tang   +3 more
semanticscholar   +1 more source

Omega-3 fatty acid supplementation affects tryptophan metabolism during a 12-week endurance training in amateur runners: a randomized controlled trial

Scientific Reports
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far.
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L. Fisk, Philip C. Calder, Jędrzej Antosiewicz   +7 more
doaj   +1 more source

Support Vector Machine Identification of Small Molecule Binders to an Understudied Allosteric Site of SARS‐CoV‐2 Mpro for Next‐Generation PROTAC‐Based Therapeutics

Archiv der Pharmazie, Volume 358, Issue 12, December 2025.
An SVM‐based ML model identified 180 potential SARS‐CoV‐2 Mpro inhibitors. MST experiments confirmed three high‐affinity binders, with one showing Kd = 2.8 ± 0.9 μM. These compounds are non‐competitive, suggesting binding to a novel allosteric site.
Enrico Mario Alessandro Fassi, Nedra Mekni, Marco Albani, Sabine Maehrlein, Annabelle Carolin Weldert, Tanja Schirmeister, Thierry Langer, Giovannf razioso   +7 more
wiley   +1 more source

Electrochemical Synthesis of Nicotinic Acid from ��-Picoline

, 1988
Department of Chemistry, Kashmir University, Srinagar-190 006 Manuscript received 18 February 1988, revised 19 May 1988, accepted 8 June 1988 Electrosyathesis or nicotinic acid from -picoline by potentiostatic oxidation is reported. Efficencies of different electrodes are compared by considering changes in concentration of anolyte and substrate ...
P. N. GUPTA, G. M. RATHER
openaire   +1 more source

Biodegradation of Picolinic Acid by Rhodococcus sp. PA18 [PDF]

Applied Sciences, 2019
Picolinic acid (PA), a C2-carboxylated pyridine derivative, is a significant intermediate used in industrial production. PA is considered hazardous for the environment and human health. In this study, a Gram-positive bacterium, Rhodococcus sp. PA18, which aerobically utilizes PA as a source of carbon and energy, was isolated.
Yanting Zhang, Junbin Ji, Siqiong Xu, Hongmei Wang, Biao Shen, Jian He, Jiguo Qiu, Qing Chen   +7 more
openaire   +2 more sources

Plectranthus‐derived Abietanes as Protein Kinase C‐δ Activators: In Silico Design, Human Serum Albumin Interaction, and Stability Evaluation

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Cancer remains a major global health challenge. Among protein kinases (PKCs), PKC‐δ acts as a tumor suppressor in colon cancer and represents a valuable therapeutic target. Human serum albumin (HSA) is gaining attention as an efficient drug carrier, while Plectranthus spp. offers a rich source of bioactive compounds.
Vera M. S. Isca, Milan Nikolić, Nenad Filipović, Mattia Mori, Patricia Rijo   +4 more
wiley   +1 more source