Results 61 to 70 of about 5,118,399 (260)

Isomerization of α‐Pinene Oxide to Trans‐Pinocarveol

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
An operationally simple protocol for the selective isomerization of α‐pinene oxide (APO) to trans‐pinocarveol (TPC) is disclosed, which leverages inexpensive pyridinium‐halide organocatalysts to mitigate competing 1,2‐alkyl shifts. The scalability of this methodology is demonstrated on a decagram scale and catalyst‐recycling is validated through the ...
Emanuel Studer, Johanna Oortmann, Ryan Gilmour   +2 more
wiley   +1 more source

Revisiting the Coordination Chemistry of Molybdenum(V): Novel Complexes with Pyrazinoate and Picolinate Ligands

Molbank
Reactions of (pyH)5[MoOCl4(H2O)]3Cl2 with picolinic and pyrazinoic acids yielded three new dinuclear molybdenum(V) complexes: (pyH)2[Mo2O4Cl2(pic)2]·CH3CN (1), (pyH)2[Mo2O4Cl2(pic)2]·CH3CH2CN (2) and (pyH)2[Mo2O4Cl2(pyraz)2]·CH3CN (3) (pic− = picolinate,
Barbara Modec, Nina Podjed Rihtaršič
doaj   +1 more source

Modulation of Amide Bond Rotamers in 5-Acyl-6,7-dihydrothieno[3,2-c]pyridines [PDF]

, 2015
2-Substituted N-acyl-piperidine is a widespread and important structural motif, found in approximately 500 currently available structures, and present in nearly 30 pharmaceutically active compounds.
Lanyon-Hogg, T, Magee, AI, Masumoto, N, Ritzefeld, M, Rzepa, HS, Tate, EW   +5 more
core   +3 more sources

Support Vector Machine Identification of Small Molecule Binders to an Understudied Allosteric Site of SARS‐CoV‐2 Mpro for Next‐Generation PROTAC‐Based Therapeutics

Archiv der Pharmazie, Volume 358, Issue 12, December 2025.
An SVM‐based ML model identified 180 potential SARS‐CoV‐2 Mpro inhibitors. MST experiments confirmed three high‐affinity binders, with one showing Kd = 2.8 ± 0.9 μM. These compounds are non‐competitive, suggesting binding to a novel allosteric site.
Enrico Mario Alessandro Fassi, Nedra Mekni, Marco Albani, Sabine Maehrlein, Annabelle Carolin Weldert, Tanja Schirmeister, Thierry Langer, Giovannf razioso   +7 more
wiley   +1 more source

Aryloxyethyl thiocyanates are potent growth inhibitors of Trypanosoma cruzi and Toxoplasma gondii [PDF]

, 2015
As a part of our project aimed at searching new safe chemotherapeutic agents against parasitic diseases, several compounds structurally related to the antiparasitic agent WC-9 (4-phenoxyphenoxyethyl thiocyanate), which were modified at the terminal ...
Chao, Maria Noelia, Docampo, Roberto, Exeni Matiuzzi, Carolina, Li, Catherine, Moreno, Silvia N. J., Rodriguez, Juan Bautista, Storey, Melissa, Szajnman, Sergio Hernan   +7 more
core   +1 more source

Plectranthus‐derived Abietanes as Protein Kinase C‐δ Activators: In Silico Design, Human Serum Albumin Interaction, and Stability Evaluation

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Cancer remains a major global health challenge. Among protein kinases (PKCs), PKC‐δ acts as a tumor suppressor in colon cancer and represents a valuable therapeutic target. Human serum albumin (HSA) is gaining attention as an efficient drug carrier, while Plectranthus spp. offers a rich source of bioactive compounds.
Vera M. S. Isca, Milan Nikolić, Nenad Filipović, Mattia Mori, Patricia Rijo   +4 more
wiley   +1 more source

Vanadyl complexes with dansyl-labelled dipicolinic acid ligands: synthesis, phosphatase inhibition activity and cellular uptake studies [PDF]

, 2016
Vanadium complexes have been previously utilised as potent inhibitors of cysteine based phosphatases (CBPs). Herein, we present the synthesis and characterisation of two new fluorescently labelled vanadyl complexes (14 and 15) with bridged di-picolinic ...
Agostino Cilibrizzi, Anderie, Cirri, Costa Pessoa, Crans, Cuncic, Dyson, Gillian Whyte, Granier, He, Huyer, Inna Guterman, Juliet Collins, Kolmodin, Levina, Li, Lodyga-Chruscinska, Lok Hang Mak, Low, Lu, Lu, Lu, Mak, Makinen, Marina Fedorova, McLauchlan, McLauchlan, Mercey, Nakai, Ostman, Pessoa, Posner, Posner, Ramon Vilar, Robin Leatherbarrow, Rosivatz, Rudiger Woscholski, Sakurai, Salmeen, Schmid, Schmid, Scott, Seale, Thompson, Uto, Vanhaesebroeck, Walker, Wang, Xu, Yuan, Zhang, Zhang   +51 more
core   +1 more source

Green and Sustainable Chemistry Approaches on Azide‐Based Click Reactions in Polymer Science

Macromolecular Rapid Communications, Volume 46, Issue 23, December 5, 2025.
Click Chemistry, particularly the azide‐alkyne cycloaddition (AAC) reaction, has revolutionized polymer chemistry, enabling precise and efficient synthesis of advanced functional materials. With its high regioselectivity, mild reaction conditions, and versatility, AAC reactions align closely with the principles of Green and Sustainable Chemistry.
Hatice Mutlu, Bercis Pektas, C. Remzi Becer, Azra Kocaarslan   +3 more
wiley   +1 more source

Omega-3 fatty acid supplementation affects tryptophan metabolism during a 12-week endurance training in amateur runners: a randomized controlled trial

Scientific Reports
The effects of long-term omega-3 polyunsaturated fatty acid (n-3 PUFA) supplementation during endurance training on tryptophan (Trp) metabolism and mental state of healthy individuals have not been evaluated so far.
Maja Tomczyk, Monika Bidzan-Wiącek, Jakub Antoni Kortas, Magdalena Kochanowicz, Zbigniew Jost, Helena L. Fisk, Philip C. Calder, Jędrzej Antosiewicz   +7 more
doaj   +1 more source

Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity [PDF]

, 2016
The free fatty acid receptor 4 (FFA4 or GPR120) has appeared as an interesting potential target for the treatment of metabolic disorders. At present, most FFA4 ligands are carboxylic acids that are assumed to mimic the endogenous long-chain fatty acid ...
Azevedo, Carlos, Christiansen, Elisabeth, Dunlop, Julia, Hansen, Steffen, Hudson, Brian, Kępczyńska, Malgorzata A., Milligan, Graeme, Shumpukade, Bharat, Stocker, Claire J., Ulven, Trond, Wargent, Edward T., Watterson, Kenneth   +11 more
core   +3 more sources