Results 181 to 190 of about 32,053 (206)

Picornavirus receptors and picornavirus multiplication in human-mouse hybrid cell lines

Virology, 1973
Abstract A series of human-mouse hybrid lines containing eight human biarmed chromosomes was found to be susceptible to infection by all the human picornaviruses tested (eight enteroviruses and two rhinoviruses). Receptors for all of these viruses were present in the hybrid cells and nearly all the receptors were determined exclusively by human genes.
L, Medrano, H, Green
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Polyprotein processing in picornavirus replication

Biochimie, 1988
The primary translation product of the picornavirus genome is a single large protein which is processed to the mature viral polypeptides by progressive, co- and post-translational cleavages. Replication of the picornaviruses is thus entirely dependent upon the proteolysis of viral precursor proteins.
H G, Kräusslich, M J, Nicklin, C K, Lee, E, Wimmer   +3 more
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Intracellular determinants of picornavirus replication

Trends in Microbiology, 1999
Viruses replicate in a restricted number of hosts and tissues. In addition to viral receptors, several intracellular factors can be involved in determining tissue tropism. Many proteins have recently been implicated in picornavirus translation and RNA replication.
R, Andino, N, Böddeker, D, Silvera, A V, Gamarnik   +3 more
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Picornavirus RNA-dependent RNA polymerase

The International Journal of Biochemistry & Cell Biology, 2009
Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined.
Chee Choy, Kok, Peter C, McMinn
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Picornavirus IRES: Structure Function Relationship

Current Pharmaceutical Design, 2004
Picornavirus infections have been a challenging problem in human health. Genome organisation of picornavirus is unique in having a long, heavily-structured, multifunctional 5'untranslated region, preceding a single open reading frame from which all viral proteins are produced.
Encarnación, Martínez-Salas, Olga, Fernández-Miragall   +1 more
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Treatment of picornavirus infections

Antiviral Research, 2002
The picornaviruses are a diverse group of viral pathogens that together comprise the most common causes of infections of humans in the developed world. Within the picornavirus family are three well-known groups of human pathogens-the enteroviruses (including polioviruses, coxsackieviruses, and echoviruses), the rhinoviruses, and the hepatoviruses ...
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Regulation of picornavirus gene expression

Microbes and Infection, 2004
Members of the Picornaviridae are positive- strand RNA viruses that cause a variety of human diseases such as poliomyelitis, the common cold, myocarditis, and hepatitis. Although the diseases caused by picornaviruses are diverse, the genome organization and mechanisms of gene expression are highly conserved among family members.
Kristin M, Bedard, Bert L, Semler
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Divergent picornavirus IRES elements

Virus Research, 2009
Internal ribosome entry site (IRES) elements were first identified about 20 years ago within the 5' untranslated region of picornavirus RNAs. They direct a cap-independent mechanism of translation initiation on the viral RNA. Within the picornavirus family it is now known that there are four classes of IRES element which vary in size (450-270 nt), they
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PICORNAVIRUS EPIDEMIC CONJUNCTIVITIS IN SINGAPORE

The Lancet, 1972
Abstract Outbreaks of picornavirus epidemic conjunctivitis in 1970 and 1971 in Singapore have been studied. The 1971 outbreak was caused by a virus identical or closely related to the acute haemorrhagic conjunctivitis (A.H.C.) virus isolated in Japan in 1971, and not by reappearance of the Singapore epidemic conjunctivitis (S.E.C.) virus (1970). The S.
M, Yin-Murphy, K H, Lim
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[(Biaryloxy)alkyl]isoxazoles: Picornavirus Inhibitors

Journal of Medicinal Chemistry, 1995
A series of biphenyl analogs, 6, of 5-[5-(2,6-dichloro-5-oxazolylphenoxy)pentyl]-3-methylisoxazole (2) have been synthesized and tested in vitro against 10 human rhinovirus serotypes in a TCID50 assay. The most potent compound in the series 6s, 3-[3-[2,6-dimethyl-4-(4-fluorophenyl)-phenoxy]propyl]-3-methylisoxazole , was screened against an additional ...
J W, Guiles, G D, Diana, D C, Pevear
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