Results 181 to 190 of about 32,243 (222)

Intracellular determinants of picornavirus replication

Trends in Microbiology, 1999
Viruses replicate in a restricted number of hosts and tissues. In addition to viral receptors, several intracellular factors can be involved in determining tissue tropism. Many proteins have recently been implicated in picornavirus translation and RNA replication.
Raul Andino
exaly   +3 more sources

Enterovirus/Picornavirus infections

2014
Abstract The human enteroviruses (EV) comprise one group of the picornavirus family. The best known members are the polioviruses (PV), coxsackieviruses, and echoviruses. They replicate in the oropharynx and gastrointestinal (GI) tract and are primarily spread by fecal-hand-oral contamination.
Burk, Jubelt, Howard L, Lipton
openaire   +2 more sources

Selective inhibitors of picornavirus replication

Medicinal Research Reviews, 2008
AbstractPicornaviruses cover a large family of pathogens that have a major impact on human but also on veterinary health. Although most infections in man subside mildly or asymptomatically, picornaviruses can also be responsible for severe, potentially life‐threatening disease.
Johan Neyts
exaly   +3 more sources

Picornavirus-Induced Immunosuppression

1989
Picornaviridae are small RNA viruses with a naked ether-resistant icosahedral capsid, 22–30 nm in diameter. The capsid is composed of four different poly peptides (VP1-VP4), three of 20–40 kDa, one of 5-10 kDa. One molecule of each makes up the capsid structural subunits and the capsid comprises 60 capsomeres.
GARZELLI, CARLO, BASOLO, FULVIO, MATTEUCCI, DONATELLA, Prabhakar BS, Toniolo A.   +4 more
openaire   +3 more sources

Picornavirus receptors and picornavirus multiplication in human-mouse hybrid cell lines

Virology, 1973
Abstract A series of human-mouse hybrid lines containing eight human biarmed chromosomes was found to be susceptible to infection by all the human picornaviruses tested (eight enteroviruses and two rhinoviruses). Receptors for all of these viruses were present in the hybrid cells and nearly all the receptors were determined exclusively by human genes.
L, Medrano, H, Green
openaire   +2 more sources

Treatment of picornavirus infections

Antiviral Research, 2002
The picornaviruses are a diverse group of viral pathogens that together comprise the most common causes of infections of humans in the developed world. Within the picornavirus family are three well-known groups of human pathogens-the enteroviruses (including polioviruses, coxsackieviruses, and echoviruses), the rhinoviruses, and the hepatoviruses ...
exaly   +3 more sources

Systematic nomenclature of picornavirus proteins [PDF]

Journal of Virology, 1984
An easily learned convention for systematizing the nomenclature of picornavirus proteins is described. The convention is based upon an idealized map, called the L434 diagram, of the picornavirus polyprotein.
R R, Rueckert, E, Wimmer
exaly   +3 more sources

Polyprotein processing in picornavirus replication

Biochimie, 1988
The primary translation product of the picornavirus genome is a single large protein which is processed to the mature viral polypeptides by progressive, co- and post-translational cleavages. Replication of the picornaviruses is thus entirely dependent upon the proteolysis of viral precursor proteins.
H G, Kräusslich, M J, Nicklin, C K, Lee, E, Wimmer   +3 more
openaire   +2 more sources

PICORNAVIRUS EPIDEMIC CONJUNCTIVITIS IN SINGAPORE

Lancet, The, 1972
Abstract Outbreaks of picornavirus epidemic conjunctivitis in 1970 and 1971 in Singapore have been studied. The 1971 outbreak was caused by a virus identical or closely related to the acute haemorrhagic conjunctivitis (A.H.C.) virus isolated in Japan in 1971, and not by reappearance of the Singapore epidemic conjunctivitis (S.E.C.) virus (1970). The S.
M, Yin-Murphy, K H, Lim
exaly   +3 more sources

Picornavirus RNA-dependent RNA polymerase

The International Journal of Biochemistry & Cell Biology, 2009
Replication of the picornavirus genome is catalysed by a viral encoded RNA-dependent RNA polymerase, termed 3D polymerase. Together with other viral and host proteins, this enzyme performs its functions in the cytoplasm of host cells. The crystal structure of 3D polymerase from a number of picornaviruses has been determined.
Chee Choy, Kok, Peter C, McMinn
openaire   +2 more sources