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Picornavirus-Induced Immunosuppression
1989Picornaviridae are small RNA viruses with a naked ether-resistant icosahedral capsid, 22–30 nm in diameter. The capsid is composed of four different poly peptides (VP1-VP4), three of 20–40 kDa, one of 5-10 kDa. One molecule of each makes up the capsid structural subunits and the capsid comprises 60 capsomeres.
GARZELLI, CARLO +4 more
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Picornavirus receptors and picornavirus multiplication in human-mouse hybrid cell lines
Virology, 1973Abstract A series of human-mouse hybrid lines containing eight human biarmed chromosomes was found to be susceptible to infection by all the human picornaviruses tested (eight enteroviruses and two rhinoviruses). Receptors for all of these viruses were present in the hybrid cells and nearly all the receptors were determined exclusively by human genes.
L, Medrano, H, Green
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Selective inhibitors of picornavirus replication
Medicinal Research Reviews, 2008AbstractPicornaviruses cover a large family of pathogens that have a major impact on human but also on veterinary health. Although most infections in man subside mildly or asymptomatically, picornaviruses can also be responsible for severe, potentially life‐threatening disease.
Armando M De Palma +2 more
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Picornavirus Infections: A Primer for the Practitioner
Archives of Family Medicine, 2000Picornaviruses, including the rhinoviruses and enteroviruses, are common causes of infections in the developed world and the most common reason for prescribing antibiotics. These ubiquitous pathogens are increasingly being recognized in more serious illnesses, such as sinusitis, exacerbations of asthma, exacerbations of cystic fibrosis, myocarditis ...
H A, Rotbart, F G, Hayden
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Isolation and characterisation of a murine picornavirus
Research in Veterinary Science, 1977Cytopathic changes were observed in uninoculated primary cultures of mouse embryo fibroblasts. A virus resembling a picornavirus was isolated from the cultures. The virus produced cytopathic changes in mouse embryo fibroblast, chicken embryo fibroblast and Vero cell cultures. It was pathogenic for suckling mice and for chick embryos.
Gaffar Elamin M., Spradbrow P.B.
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Polyprotein processing in picornavirus replication
Biochimie, 1988The primary translation product of the picornavirus genome is a single large protein which is processed to the mature viral polypeptides by progressive, co- and post-translational cleavages. Replication of the picornaviruses is thus entirely dependent upon the proteolysis of viral precursor proteins.
H G, Kräusslich +3 more
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Evolutionary analysis of the picornavirus family
Journal of Molecular Evolution, 1995An exhaustive evolutionary analysis of the picornavirus family has been carried out using the amino acid sequences of several proteins of the viruses including: the capsid proteins (1D, 1B, and 1C) situated at the 5' end of the genome and responsible for the serotype of the viruses, and the viral polymerase (3D), located at the 3' end of the genome ...
M J, Rodrigo, J, Dopazo
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Characterization of vilyuisk virus as a picornavirus
Journal of Medical Virology, 1983AbstractThe V‐1 strain of Vilyuisk virus, isolated from the cerebrospinal fluid of a chronic case of encephalomyelitis in Siberia and subsequently passaged 41 times in mice, was examined to determine its serological relationship to Theiler's murine encephalomyelitis virus (TMEV) and encephalomyocarditis (EMC) virus and some physicochemical ...
H L, Lipton +3 more
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Regulation of picornavirus gene expression
Microbes and Infection, 2004Members of the Picornaviridae are positive- strand RNA viruses that cause a variety of human diseases such as poliomyelitis, the common cold, myocarditis, and hepatitis. Although the diseases caused by picornaviruses are diverse, the genome organization and mechanisms of gene expression are highly conserved among family members.
Kristin M, Bedard, Bert L, Semler
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