PIEZO2 in tumors: from mechanobiological switches to activity-targeted therapies [PDF]
Journal of Experimental & Clinical Cancer ResearchMechanosensitive ion channel PIEZO2 translates microenvironmental forces into Ca²⁺-dependent signals that shape tumor behavior. Across cancers, PIEZO2 exhibits context-dependent roles, with evidence for both pro- and anti-tumor functions, depending on ...
Dan-xia Huang +6 more
doaj +2 more sources
Trigeminal nerve root compression induced neuroinflammatory response promotes mechanical allodynia through the CGRP/SP-Piezo2 axis via Ca2+ signaling [PDF]
Cellular & Molecular Biology LettersTrigeminal neuralgia (TN) is one of the most severe types of neuropathic pain, but its pathological mechanisms remain unknown. In this study, we identified a unique neuroinflammatory response induced by chronic compression of trigeminal root entry zone ...
Xinyue Liao +9 more
doaj +2 more sources
Immunohistochemical Detection of the Mechano-Gated Piezo Channels in the Normal Endometrium and in Endometriosis [PDF]
BiomoleculesEndometriosis is an inflammatory estrogen-dependent disorder characterized by pain, dyspareunia, dysmenorrhea, and infertility. This is due to the invasion of different organs by endometrial tissue that causes inflammation, angiogenesis, and fibrosis ...
Angel Sánchez del Rio +7 more
doaj +2 more sources
Chondrocyte-specific knockout of Piezo1 and Piezo2 protects against post-traumatic osteoarthritis structural damage and pain in mice [PDF]
Arthritis Research & TherapyBackground Osteoarthritis (OA) is a debilitating joint disease characterized by cartilage degeneration, synovial inflammation, and bone remodeling, with limited therapeutic options targeting the underlying pathophysiology.
Erica V. Ely +10 more
doaj +2 more sources
TET3 is a regulator and can be targeted for the intervention of myocardial fibrosis [PDF]
EMBO Molecular MedicineCardiac fibrosis contributes to adverse cardiac remodeling and loss of heart function eventually leading to heart failure (HF). Resident cardiac fibroblasts are the principal source of myofibroblasts that produce extracellular matrix proteins to mediate ...
Chenghao Zhu +7 more
doaj +2 more sources
Mechanotransduction Pathways in Massage Therapy: CB1/Piezo2 Receptor Crosstalk Modulates Myocellular Anti-Inflammatory Responses [PDF]
Journal of Pain ResearchQian Liu,1 Wen He,2 Man Li,3 Zeyun Li,4 Cai Wu4 1School of Sports and Health, Hubei University of Chinese Medicine, Wuhan, People’s Republic of China; 2Department of Rehabilitation Medicine, Wuhan Red Cross Hospital, Wuhan, People’s Republic of China ...
Liu Q, He W, Li M, Li Z, Wu C
doaj +2 more sources
Piezo in the eye: expression, distribution and roles in ocular diseases [PDF]
Frontiers in PhysiologyPiezo channels are currently known to be the most sensitive molecular mechanoreceptors. Piezo can respond to membrane tension, sag, shear force, tensile and other mechanical stimuli, produces fast inactivation, small conductance, and low threshold ...
Li Zhu +4 more
doaj +2 more sources
Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons [PDF]
International Journal of Oral SciencePiezo2, a mechanosensitive ion channel, serves as a crucial mechanotransducer in dental primary afferent (DPA) neurons and is potentially involved in hypersensitivity to mild mechanical irritations observed in dental patients.
Pa Reum Lee +4 more
doaj +2 more sources
A pan-cancer analysis reveals the genetic alterations and immunotherapy of Piezo2 in human cancer
Frontiers in Genetics, 2022 Background: Piezo2 is a transmembrane-spanning ion channel protein implicated in multiple physiological processes, including cell proliferation and angiogenesis in many cell types.
Xin Liu +5 more
doaj +1 more source
Frontiers in Physiology, 2021 Piezo2 is a mechanically gated ion-channel that has a well-defined role in innocuous mechanical sensitivity, but recently has also been suggested to play a role in mechanically induced pain.
Sara Nencini +5 more
doaj +1 more source