Results 11 to 20 of about 5,132 (198)
Contribution of Piezo2 to Endothelium-Dependent Pain [PDF]
Molecular Pain, 2015 Background We evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced enhancement of hyperalgesia that is vascular endothelial cell dependent.
Ferrari, Luiz F +3 more
openaire +8 more sources
Inflammatory Signals Enhance Piezo2-Mediated Mechanosensitive Currents [PDF]
Cell Reports, 2012 Heightened nociceptor function caused by inflammatory mediators such as bradykinin (BK) contributes to increased pain sensitivity (hyperalgesia) to noxious mechanical and thermal stimuli.
Adrienne E. Dubin +6 more
doaj +4 more sources
Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction [PDF]
Cell Reports, 2017 Summary: Piezo2 is a mechanically activated ion channel required for touch discrimination, vibration detection, and proprioception. Here, we discovered that Piezo2 is extensively spliced, producing different Piezo2 isoforms with distinct properties ...
Marcin Szczot +7 more
doaj +3 more sources
Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis
Nature Communications, 2023 Non-opioid targets are needed for addressing osteoarthritis pain, which is mechanical in nature and associated with daily activities such as walking and climbing stairs. Piezo2 has been implicated in the development of mechanical pain, but the mechanisms
Alia M. Obeidat +10 more
doaj +3 more sources
Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome [PDF]
Nature Communications, 2023 Angelman syndrome (AS) is a neurogenetic disorder. Here, the authors found that PIEZO2 activity is reduced in sensory neurons from a mouse model of AS and used a linoleic acid-enriched diet to enhance PIEZO2 function and ameliorate AS-associated gait ...
Luis O. Romero +11 more
doaj +2 more sources
TMEM120A/TACAN inhibits mechanically activated Piezo2 channels [PDF]
Journal of General Physiology, 2021 ABSTRACTMechanically activated Piezo2 channels are key mediators of light touch and proprioception in mice and humans. Relatively little is known about what other proteins regulate Piezo2 activity in a cellular context. TACAN (TMEM120A) was proposed to act as a high threshold mechanically activated ion channel in nociceptive dorsal root ganglion (DRG ...
John Smith Del Rosario +3 more
openaire +2 more sources
Merkel Cell Carcinoma Display PIEZO2 Immunoreactivity
Journal of Personalized Medicine, 2022 As an essential component of mechano-gated ion channels, critically required for mechanotransduction in mammalian cells, PIEZO2 is known to be characteristically expressed by Merkel cells in human skin. Here, we immunohistochemically investigated the occurrence of Piezo channels in a case series of Merkel cell carcinoma.
Yolanda García-Mesa +8 more
openaire +5 more sources
Acta Pharmaceutica Sinica B, 2023 Vincristine, a widely used chemotherapeutic agent for treating different cancer, often induces severe peripheral neuropathic pain. A common symptom of vincristine-induced peripheral neuropathic pain is mechanical allodynia and hyperalgesia.
Mingli Duan +6 more
doaj +1 more source
The Form and Function of PIEZO2
Annual Review of Biochemistry, 2021 Mechanosensation is the ability to detect dynamic mechanical stimuli (e.g., pressure, stretch, and shear stress) and is essential for a wide variety of processes, including our sense of touch on the skin. How touch is detected and transduced at the molecular level has proved to be one of the great mysteries of sensory biology.
Marcin, Szczot +3 more
openaire +3 more sources
Piezo2 regulates colonic mechanical sensitivity in a sex specific manner in mice
Nature Communications, 2023 The mechanosensitive ion channel Piezo2 in mucosa and primary afferents transduces colonic mechanical sensation. Here we show that chemogenetic activation or nociceptor-targeted deletion of Piezo2 is sufficient to regulate colonic mechanical sensitivity ...
Jonathan Madar +6 more
doaj +1 more source