Results 21 to 30 of about 5,132 (198)
Journal of Integrative Neuroscience, 2021 Here we use immunohistochemistry to examine the expression of Piezo2 in neurons of the mouse dorsal root ganglia and brain. Whereas Piezo2 is expressed in the large majority (≥ 90%) of dorsal root ganglia neurons, Piezo2 expression is restricted to ...
Jigong Wang +1 more
doaj +1 more source
Piezo2 is not an indispensable mechanosensor in murine cardiomyocytes
Scientific Reports, 2022 A short-term increase in ventricular filling leads to an immediate (Frank-Starling mechanism) and a slower (Anrep effect) rise in cardiac contractility, while long-term increased cardiac load (e.g., in arterial hypertension) decreases contractility ...
Benjamin Kloth +10 more
doaj +1 more source
206 The Role of Mechanosensitive Ion Channels in Primary Open Angle Glaucoma
Journal of Clinical and Translational Science, 2022 OBJECTIVES/GOALS: Intraocular pressure is the most significant risk factor for glaucoma. Mechanosensitive proteins may have a critical role in transducing mechanical stimuli that ultimately lead to death of retinal ganglion cells.
Wendy Liu +3 more
doaj +1 more source
PIEZO2 in somatosensory neurons controls gastrointestinal transit
Cell, 2023 The gastrointestinal tract is in a state of constant motion. These movements are tightly regulated by the presence of food and help digestion by mechanically breaking down and propelling gut content. Mechanical sensing in the gut is thought to be essential for regulating motility; however, the identity of the neuronal populations, the molecules ...
M. Rocio Servin-Vences +13 more
openaire +2 more sources
PIEZO2, a mechanosensor in the urinary bladder
Kidney International, 2021 What did the study show? Marshall et al. first showed that PIEZO2 is expressed in >70% of umbrella cells, which constitute the innermost layer of the urothelium, and in >80% of afferent neurons. [...]
Gailly, Philippe, Devuyst, Olivier
openaire +3 more sources
Piezo2 is required for Merkel-cell mechanotransduction [PDF]
Nature, 2014 How we sense touch remains fundamentally unknown. The Merkel cell-neurite complex is a gentle touch receptor in the skin that mediates slowly adapting responses of Aβ sensory fibres to encode fine details of objects. This mechanoreceptor complex was recognized to have an essential role in sensing gentle touch nearly 50 years ago.
Woo, Seung-Hyun +11 more
openaire +2 more sources
eLife, 2018 Piezo2 ion channels are critical determinants of the sense of light touch in vertebrates. Yet, their regulation is only incompletely understood. We recently identified myotubularin related protein-2 (Mtmr2), a phosphoinositide (PI) phosphatase, in the ...
Pratibha Narayanan +7 more
doaj +1 more source
Scientific Reports, 2022 The kidney plays a central role in body fluid homeostasis. Cells in the glomeruli and juxtaglomerular apparatus sense mechanical forces and modulate glomerular filtration and renin release.
Yuki Mochida +9 more
doaj +1 more source
Biophysica, 2023 This opinion manuscript outlines how the hippocampal theta rhythm could receive two novel peripheral inputs. One of the ways this could be achieved is through Piezo2 channels and atypical hippocampal-like metabotropic glutamate receptors coupled to ...
Balázs Sonkodi
doaj +1 more source
Dabbling with Piezo2 for mechanosensation [PDF]
Proceedings of the National Academy of Sciences, 2017 Nature has devised various strategies for sensing food so species can coexist and exploit different types of prey. Sharks can detect amino acids in blood as low as 1 ppb, while hawks and buzzards scan the Earth from a height of ∼10,000 feet looking for rodents. However, not all birds rely on their keen sense of sight to acquire food.
openaire +2 more sources