Results 101 to 110 of about 19,713 (201)

Mouse genome engineering uncovers 18 genes dispensable for male reproduction

Andrology, Volume 14, Issue 3, Page 833-846, March 2026.
Abstract Background Male infertility is an intricate multifactorial disease involving the interplay between genetic and environmental factors. Genetic anomalies account for more than 15% of all male infertility cases; however, diagnosing them exhibits enormous challenges due to variable symptomatic presentations and limited knowledge of gene functions.
Hsin‐Yi Chang, Yonggang Lu, Kaito Yamamoto, Jiang Sun, Keisuke Shimada, Yuki Hiradate, Yoshitaka Fujihara, Masahito Ikawa   +7 more
wiley   +1 more source

Three charged particles in the continuum. Astrophysical examples

, 2003
We suggest a new adiabatic approach for description of three charged particles in the continuum. This approach is based on the Coulomb-Fourier transformation (CFT) of three body Hamiltonian, which allows to develop a scheme, alternative to Born ...
Alt E O, Alt E O, Alt E O, Alt E O, Alt E O, Alt E O Levin S B Yakovlev S L W Glöckle T Pulis W Tornow, Belyaev V B Levin S L Yakovlev S L W Glöckle T Pulis W Tornow, Brauner M, Faddeev L D, Gradshteyn I S, Kim Y E, Kuchiev M Yu, Levin S B, Macek J H, Merkuriev S P, Peterkop R K, Peterkop R K, Peterkop R K, S B Levin, S L Yakovlev, V B Belyaev   +20 more
core   +1 more source

Effects of Pin1 loss in HdhQ111 knock-in mice

Frontiers in Cellular Neuroscience, 2016
Huntington’s disease (HD) is a fatal, dominantly inherited, neurodegenerative disorder due to a pathological expansion of the CAG repeat in the coding region of the HTT gene.
Elena eAgostoni, Silvia eMichelazzi, Marta eMaurutto, Alisia eCarnemolla, Yari eCiani, Yari eCiani, Paolo eVatta, Paola eRoncaglia, Paola eRoncaglia, Silvia eZucchelli, Silvia eZucchelli, Giampiero eLeanza, Fiamma eMantovani, Fiamma eMantovani, Stefano eGustincich, Stefano eGustincich, Claudio eSantoro, Silvano ePiazza, Silvano ePiazza, Giannino eDel Sal, Giannino eDel Sal, Francesca ePersichetti   +21 more
doaj   +1 more source

Pin1 plays a key role in the response to treatment and clinical outcome in triple negative breast cancer

Therapeutic Advances in Medical Oncology, 2020
Background: Triple negative breast cancer (TNBC) is the subset of breast cancer associated with the poorest outcome, and currently lacks targeted treatments.
Catherine Knowlson, Paula Haddock, Victoria Bingham, Stephen McQuaid, Paul B. Mullan, Niamh E. Buckley   +5 more
doaj   +1 more source

User Guide for AutoCSM: Automated Capacity Spectrum Method of Analysis [PDF]

, 2004
No Abstract ...
Guyader, Andrew, Iwan, Wilfred D.
core  

A Metalanguage for Guarded Iteration

, 2018
Notions of guardedness serve to delineate admissible recursive definitions in various settings in a compositional manner. In recent work, we have introduced an axiomatic notion of guardedness in symmetric monoidal categories, which serves as a unifying ...
A Carboni, B Geron, E Giménez, E Giménez, E Moggi, G Plotkin, G Winskel, JRB Cockett, K Nakata, K Nakata, Keiko Nakata, Keiko Nakata, L Birkedal, M Hyland, N Benton, PB Levy, R Clouston, R Milner, S Abramsky, S Bloom, S Goncharov, S Goncharov, S Goncharov, S Goncharov, S Mac Lane, S Milius, T Coquand, WW Tait   +27 more
core   +1 more source

Investigating dynamic interdomain allostery in Pin1

Biophysical Reviews, 2015
Signaling proteins often sequester complementary functional sites in separate domains. How do the different domains communicate with one another? An attractive system to address this question is the mitotic regulator, human Pin1 (Lu et al. 1996). Pin-1 consists of two tethered domains: a WW domain for substrate binding, and a catalytic domain for ...
openaire   +3 more sources

Blood-testis barrier integrity depends on Pin1 expression in Sertoli cells

Scientific Reports, 2017
The conformation and function of a subset of serine and threonine-phosphorylated proteins are regulated by the prolyl isomerase Pin1 through isomerization of phosphorylated Ser/Thr-Pro bonds. Pin1 is intensely expressed in Sertoli cells, but its function
Rabia Islam, Heein Yoon, Bong-soo Kim, Han-sol Bae, Hye-rim Shin, Woo-Jin Kim, Won-joon Yoon, Yun-Sil Lee, Kyung Mi Woo, Jeong-Hwa Baek, Hyun-Mo Ryoo   +10 more
doaj   +1 more source

PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD)

Metabolism Open, 2019
Objective: A novel genetic and molecular basis of nonalcoholic fatty liver disease (NAFLD) was explored. Study design: A 38-year-old male, who has no bad living and dietary habits, was diagnosed as NAFLD.
Jing-Zhang Wang, Yu-Hua Zhang, Jing Bai, Yan-Wei Liu, Wen-Tao Du   +4 more
doaj   +1 more source

Pin1 in Acute Myeloid Leukemia Blast Cells.

Blood, 2005
Abstract Pin1 is a peptidyl-prolyl-isomerase catalysing conformational changes on ser/thr-pro-sites of proteins, and has been shown to play a pivotal role for the activity of cell cycle regulating proteins in breast and prostate cancer cells.
Hangen, H., Reinhard, D., Griesinger, Frank, Truemper, Lorenz H., Wulf, G. M., Wulf, Gerald G.   +5 more
openaire   +2 more sources