Results 111 to 120 of about 19,713 (201)
An Ising-Like model for protein mechanical unfolding
, 2007 The mechanical unfolding of proteins is investigated by extending the Wako-Saito-Munoz-Eaton model, a simplified protein model with binary degrees of freedom, which has proved successful in describing the kinetics of protein folding.
A. Imparato +7 more
core +1 more source
Ecotoxicology and Environmental SafetyExposure to fine particulate matter (PM2.5) has been increasingly associated with neurodevelopmental disorders, yet the underlying molecular mechanisms remain poorly defined. KDM5A, a histone lysine demethylase implicated in cognitive regulation, has not
Chao Song +10 more
doaj +1 more source
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action
Nature Communications, 2017 PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a ...
Elena Campaner +23 more
doaj +1 more source
An ultra fast optical header replacement technology and its application for broadband optical packet switch. [PDF]
, 2001 An optical header replacement technology based on Self Electro-optic Effect Devices (SEEDs) is presented. By using the measurement result of a 75 μm long SEED device, we simulate an 8 Gbps throughput is achievable.
Beuwer, Wim, Etten, Wim van, Tian, Bo
core +1 more source
, 2022 В даній роботі були проаналізовані відомі інгібітори, їх переваги і недоліки, а також синтезовано нові макроциклічні інгібітори PIN1 для майбутніх досліджень активації світлом. Ізомер, що генерується видимим світлом демонструє набагато сильнішу токсичність проти пухлинних клітин, ніж ізомер, що утворюється під ультрафіолетом.
openaire +1 more source
The Prolyl Isomerase Pin1 in Breast Development and Cancer [PDF]
, 2011 The prolyl isomerase Pin1 specifically isomerizes certain phosphorylated Ser/Thr-Pro bonds and thereby regulates various cellular processes. Pin1 is a target of several oncogenic pathways and is overexpressed in human breast cancer.
Liou, Yih-Cherng +3 more
core
Research progress of the impact of Pin1 on the pathogenesis of Alzheimer's disease
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 Peptidyl-prolyl cis/trans isomerase (Pin1) has been identified as an important factor that can affect many neurodegenerative diseases as well as neoplasms.
Wei LI, Shi-fu XIAO
doaj
Informed Trading, Information Asymmetry and Pricing of Information Risk: Empirical Evidence from the NYSE [PDF]
We analyze commonality in informed trading across stocks, and how informed trading varies with the structural and trading characteristics of a firm.
Bardong, Florian +2 more
core +1 more source
Prolyl-isomerase Pin1 drives platinum resistance by regulating Notch3 stability and function in ovarian cancer. [PDF]
J Exp Clin Cancer ResGiuli MV +29 more
europepmc +1 more source