Results 11 to 20 of about 19,713 (201)
Journal of Plant Nutrition and Soil Science, EarlyView., 2023 Abstract Background Plant responses to deficiencies of the micronutrient boron are diverse and go beyond the well‐characterized function of boron in cell wall crosslinking. To explain these phenotypic discrepancies, hypotheses about interactions of boron with various phytohormones have been proposed, particularly auxin.
Michaela S. Matthes +3 more
wiley +1 more source
Pin1 in Neuronal Apoptosis [PDF]
Cell Cycle, 2007 While the role of the prolyl isomerase Pin1 in dividing cells has long been recognized, Pin1's function in postmitotic neurons is poorly understood. We have identified a novel mechanism by which Pin1 mediates activation of the mitochondrial cell death machinery specifically in neurons.
Becker, E, Bonni, A
openaire +2 more sources
Pin1 and JNK1 cooperatively modulate TAp63γ [PDF]
FEBS Open Bio, 2021 Thep63gene encodes at least 10 isoforms, which can be classified into TA and ∆N isotypes (TAp63 and ∆Np63 proteins) according to their differences at the N termini. TAp63γ is an important transcription factor. We previously reported that peptidyl‐prolyl isomerase (PPI) Pin1 directly binds to TAp63γ protein and identified that serine 12 (S12) in the ...
Xueying Fan +6 more
openaire +3 more sources
Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma. [PDF]
PLoS ONE, 2016 BACKGROUND:Nasopharyngeal carcinoma (NPC) is a peculiar Epstein Barr virus (EBV)-associated malignancy that is prevalent in South-East Asia. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) isomerizes specific phosphorylated amino acid ...
Meng Xu +5 more
doaj +1 more source
Post-translational Modifications of the Peptidyl-Prolyl Isomerase Pin1
Frontiers in Cell and Developmental Biology, 2020 The peptidyl-prolyl cis/trans isomerase (PPIase) Pin1 is a unique enzyme that only binds to Ser/Thr-Pro peptide motifs after phosphorylation and regulates the conformational changes of the bond.
Dongmei Chen, Long Wang, Tae Ho Lee
doaj +1 more source
The prolyl isomerase Pin1 modulates development of CD8+ cDC in mice. [PDF]
PLoS ONE, 2012 Pin1 has previously been described to regulate cells that participate in both innate and adaptive immunity. Thus far, however, no role for Pin1 has been described in modulating conventional dendritic cells, innate antigen presenting cells that potently ...
Theresa J Barberi +4 more
doaj +1 more source
Complete Determination of the Pin1 Catalytic Domain Thermodynamic Cycle by NMR Lineshape Analysis [PDF]
, 2011 The phosphorylation-specific peptidyl-prolyl isomerase Pin1 catalyzes the isomerization of the peptide bond preceding a proline residue between cis and trans isomers.
De, Soumya +5 more
core +2 more sources
An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [PDF]
, 2015 Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and
Doyle, Siamsa M +10 more
core +1 more source
Immunohistochemical Expression of Cyclin D1 and PIN1 in Endometrial Carcinoma [PDF]
International Journal of Medical Arts, 2021 Background: Cyclin D1, a positive regular of the cell cycle, may lead to uncontrolled cell proliferation. Overexpression of Cyclin D1 has been associated with the diagnosis and prognosis of numerous tumors.
Shimaa Abu_Seadah +2 more
doaj +1 more source
The linchpin? Pin1 meets p73 [PDF]
Cancer Cell, 2004 A recent paper shows that the peptidyl-prolyl isomerase Pin1 conformationally alters p73, promoting its acetylation by p300 in a c-Abl dependent manner. Given previous findings with p53, Pin1 may represent a common mediator linking proapoptotic cooperative activity of the p53 family members.
Urist, Marshall, Prives, Carol
openaire +2 more sources