Results 71 to 80 of about 15,787 (93)

PINK1: The guard of mitochondria

Life Sciences, 2020
PTEN-induced putative kinase 1 (PINK1) performs many important functions in cells and has been highlighted for its role in early-onset Parkinson's disease. In recent years, an increasing number of studies have revealed the involvement of PINK1 in regulation of a variety of cell physiological and pathophysiological processes, of which regulation of ...
Nan, Wang, Peining, Zhu, Renxuan, Huang, Chong, Wang, Liankun, Sun, Beiwu, Lan, Yichun, He, Hongyang, Zhao, Yufei, Gao   +8 more
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Hsp70 participates in PINK1-mediated mitophagy by regulating the stability of PINK1

Neuroscience Letters, 2018
Loss-of function mutations in PTEN-induced putative kinase 1 (PINK1) is one of the most common causes of autosomal recessive Parkinson's disease (PD). PINK1-mediated mitophagy is critical to mitochondrial quality control and plays an important role in PD pathogenesis.
Qian, Zheng, Chuxin, Huang, Jifeng, Guo, Jieqiong, Tan, Chunyu, Wang, Beisha, Tang, Hainan, Zhang   +6 more
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PINK1 signalling in cancer biology

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014
PTEN-induced kinase 1 (PINK1) was identified initially in cancer cells as a gene up-regulated by overexpression of the major tumor suppressor, PTEN. Loss-of-function mutations in PINK1 were discovered subsequently to cause autosomal recessive Parkinson's disease.
Ciara H, O'Flanagan, Cora, O'Neill
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In the PINK1

Science, 2014
Mitochondria lacking a Parkinson’s disease–associated kinase harbor a functionally important phosphorylation defect.
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PINK1 and Parkin: The odd couple

Neuroscience Research, 2020
In 2004, PINK1 was established as a gene linked to early onset of autosomal recessive juvenile Parkinsonism. Since then, tremendous efforts allowed involving the gene product in diverse events but with a strong focus on its partnership with the protein Parkin for the degradation of damaged mitochondria through mitophagy.
Yoboue, Edgar Djaha, Valente, Enza Maria
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Pyruvate stimulates mitophagy via PINK1 stabilization

Cellular Signalling, 2015
Damaged mitochondria are targeted for degradation by an autophagy pathway known as mitophagy. Despite efforts to unravel the mechanisms underlying mitophagy, aspects of mitophagy regulation remain largely unknown. In this study, by using a cell-based fluorescence assay reflecting CCCP-induced mitophagy, we have screened cDNA expression library encoding
Sungwoo, Park, Seon-Guk, Choi, Seung-Min, Yoo, Jihoon, Nah, Eunil, Jeong, Hyunjoo, Kim, Yong-Keun, Jung   +6 more
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The PINK1–Parkin axis: An Overview

Neuroscience Research, 2020
Parkin is a protein involved in familial Parkinson's disease (PD), a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons. More than 20 years have passed since the discovery of Parkin; since that time, another familial PD protein has been identified: PINK1, which acts upstream of Parkin.
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Genetic mutations and functions of PINK1

Trends in Pharmacological Sciences, 2011
Parkinson's disease (PD) is the second most common neurodegenerative disease. Mutations in PINK1 (PARK6) are the second most frequent cause of autosomal recessive, young-onset PD, after parkin (PARK2). PINK1 (a kinase with an N-terminal mitochondrial targeting sequence) provides protection against mitochondrial dysfunction and regulates mitochondrial ...
Sumihiro, Kawajiri, Shinji, Saiki, Shigeto, Sato, Nobutaka, Hattori   +3 more
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Molecular Mechanisms of PINK1-Related Neurodegeneration

Current Neurology and Neuroscience Reports, 2011
PINK1 is a mitochondrially targeted kinase that has been linked to a rare monogenic form of Parkinson's disease (PD), a common neurodegenerative disease characterized by the degeneration of selected dopaminergic neurons. Intensive research using many model systems has clearly established a fundamental role for PINK1 in preventing mitochondrial ...
Joe H, Pogson, Rachael M, Ivatt, Alexander J, Whitworth   +2 more
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Parkin stabilizes PINK1 through direct interaction

Biochemical and Biophysical Research Communications, 2009
Parkinson disease (PD) is the most common movement disorder and is characterized by dopaminergic dysfunction. The majority of PD cases are sporadic; however, the discovery of genes linked to rare familial forms of the disease has provided crucial insight into the molecular mechanisms of disease pathogenesis.
Kahori, Shiba, Takeo, Arai, Shigeto, Sato, Shin-ichiro, Kubo, Yusuke, Ohba, Yoshikuni, Mizuno, Nobutaka, Hattori   +6 more
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