Results 1 to 10 of about 58,554 (177)

PIP2 determines length and stability of primary cilia by balancing membrane turnovers

Communications Biology, 2022
By using methods to synthesise or degrade PIP2 selectively in the ciliary membrane, Stilling et al. find that PIP2 levels determine the length of primary cilia.
Simon Stilling, Theodoros Kalliakoudas, Hannah Benninghoven-Frey, Takanari Inoue, Björn H Falkenburger   +4 more
doaj   +2 more sources

PIP2, An Auxin Induced Plant Peptide Hormone Regulates Root and Hypocotyl Elongation in Arabidopsis

Frontiers in Plant Science, 2021
Auxin is one of the traditional plant hormones, whereas peptide hormones are peptides with hormone activities. Both auxin and plant peptide hormones regulate multiple aspects of plant growth and development, and there are cross-talks between auxin and ...
Saddam Hussain, Saddam Hussain, Wei Wang, Sajjad Ahmed, Xutong Wang, Adnan, Yuxin Cheng, Chen Wang, Yating Wang, Na Zhang, Hainan Tian, Siyu Chen, Xiaojun Hu, Tianya Wang, Shucai Wang, Shucai Wang   +15 more
doaj   +2 more sources

Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2

Nature Communications, 2023
BTR1 (SLC4A11) is a NH3 stimulated H+ (OH-) transporter belonging to the SLC4 family. Dysfunction of BTR1 leads to diseases such as congenital hereditary endothelial dystrophy (CHED) and Fuchs endothelial corneal dystrophy (FECD).
Yishuo Lu, Peng Zuo, Hongyi Chen, Hui Shan, Weize Wang, Zonglin Dai, He Xu, Yayu Chen, Ling Liang, Dian Ding, Yan Jin, Yuxin Yin   +11 more
doaj   +2 more sources

Striking a balance: PIP2 and PIP3 signaling in neuronal health and disease

Exploration of Neuroprotective Therapy, 2021
Phosphoinositides are membrane phospholipids involved in a variety of cellular processes like growth, development, metabolism, and transport. This review focuses on the maintenance of cellular homeostasis of phosphatidylinositol 4,5-bisphosphate (PIP2 ...
Kamran Tariq, Bryan W. Luikart
doaj   +2 more sources

Structure of an open KATP channel reveals tandem PIP2 binding sites mediating the Kir6.2 and SUR1 regulatory interface

Nature Communications
ATP-sensitive potassium (KATP) channels, composed of four pore-lining Kir6.2 subunits and four regulatory sulfonylurea receptor 1 (SUR1) subunits, control insulin secretion in pancreatic β-cells.
Camden M. Driggers, Yi-Ying Kuo, Phillip Zhu, Assmaa ElSheikh, Show-Ling Shyng   +4 more
doaj   +2 more sources

Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

eLife, 2020
G-protein-gated inward rectifier potassium (GIRK) channels are regulated by G proteins and PIP2. Here, using cryo-EM single particle analysis we describe the equilibrium ensemble of structures of neuronal GIRK2 as a function of the C8-PIP2 concentration.
Yiming Niu, Xiao Tao, Kouki K Touhara, Roderick MacKinnon   +3 more
doaj   +2 more sources

Small Nucleolar RNA from S. cerevisiae Binds to Phosphatidylinositol 4,5-Bisphosphate [PDF]

Non-Coding RNA
Background: snoRNAs have traditionally been known for their role as guides in post-transcriptional rRNA modifications. Previously, our research group identified several RNAs that may bind to PIP2 with LIPRNA-seq.
Irma A. Jiménez-Ramírez, Miguel A. Uc-Chuc, Luis Carlos Rodríguez Zapata, Enrique Castaño   +3 more
doaj   +2 more sources

ATP competes with PIP2 for binding to gelsolin. [PDF]

PLoS ONE, 2018
Gelsolin is a severing and capping protein that targets filamentous actin and regulates filament lengths near plasma membranes, contributing to cell movement and plasma membrane morphology. Gelsolin binds to the plasma membrane via phosphatidylinositol 4,
Dávid Szatmári, Bo Xue, Balakrishnan Kannan, Leslie D Burtnick, Beáta Bugyi, Miklós Nyitrai, Robert C Robinson   +6 more
doaj   +2 more sources

PIP2-dependent coupling of voltage sensor and pore domains in Kv7.2 channel

Communications Biology, 2021
Pant et al. describe the mechanism by which PIP2 might regulate homomeric Kv7.2 channels. They identify sites important in the binding of the PIP2 lipid to Kv7.2 channels and propose that the PIP2 binding to a specific site results in the coupling ...
Shashank Pant, Jiaren Zhang, Eung Chang Kim, Kin Lam, Hee Jung Chung, Emad Tajkhorshid   +5 more
doaj   +2 more sources

Cells adapt to extracellular acidic pH through TM9SF3-mediated PI(4,5)P2 flop [PDF]

Nature Communications
The plasma membrane (PM), a physical barrier separating cells from their environment, responds to fluctuating extracellular environment through receptor-mediated signaling. While these pathways have been extensively studied, the role of PM lipids remains
Keisuke Sako, Yusuke V. Morimoto, Shin Morioka, Junya Hasegawa, Hiroyuki Nakajima, Moe Fukumoto, Yuya Nishida, Yasunori Shintani, Junko Sasaki, Takehiko Sasaki, Kazu Kikuchi, Naoki Mochizuki   +11 more
doaj   +2 more sources