Results 11 to 20 of about 58,639 (259)
Biomolecules, 2023 Metazoan cell nuclei contain non-membrane pools of the phosphoinositide lipid PI(4,5)P2 (PIP2), but how this hydrophobic lipid exists within the aqueous nucleoplasm remains unclear.
Ethan S. Chi +2 more
doaj +3 more sources
Identification of postsynaptic phosphatidylinositol-4,5-bisphosphate (PIP2) roles for synaptic plasticity using chemically induced dimerization [PDF]
Scientific Reports, 2017 Phosphatidylinositol-4,5-bisphosphate (PIP2), one of the key phospholipids, directly interacts with several membrane and cytosolic proteins at neuronal plasma membranes, leading to changes in neuronal properties including the feature and surface ...
Su-Jeong Kim +6 more
doaj +2 more sources
CD9‐association with PIP2 areas is regulated by a CD9 salt bridge [PDF]
FEBS Open BioTetraspanins are membrane proteins involved in multiple cellular functions, which they regulate by means of tetraspanin‐enriched microdomains. While many tetraspanin‐associated processes are regulated by intracellular signaling, possibly through the ...
Yahya Homsi +2 more
doaj +2 more sources
The membrane electric field regulates the PIP2-binding site to gate the KCNQ1 channel
Proceedings of the National Academy of Sciences of the United States of America, 2023 Significance Voltage-gated ion channels underlie electrical signaling in cells. The structures and functions of voltage-dependent K+, Na+, and Ca2+ and transient receptor potential ion channels have been studied extensively since their discovery. Despite
V. Mandala, R. MacKinnon
semanticscholar +1 more source
PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription
Biomolecules, 2023 The specific post-translational modifications of the C-terminal domain (CTD) of the Rpb1 subunit of RNA polymerase II (RNAPII) correlate with different stages of transcription.
C. Balaban +5 more
semanticscholar +1 more source
Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP2
Science, 2022 The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals.
Ying Yin +6 more
semanticscholar +1 more source
Frontiers in Immunology, 2022 Gene transcription is governed by epigenetic regulation that is essential for the pro-inflammatory mediators surge following pathological triggers. Acute lung injury (ALI) is driven by pro-inflammatory cytokines produced by the innate immune system ...
Shan Han +7 more
semanticscholar +1 more source
Autoinhibition of TRPV6 Channel and Regulation by PIP2 [PDF]
iScience, 2020 Transient receptor potential vanilloid 6 (TRPV6), a calcium-selective channel possessing six transmembrane domains (S1-S6) and intracellular N and C termini, plays crucial roles in calcium absorption in epithelia and bone and is involved in human diseases including vitamin-D deficiency, osteoporosis, and cancer. The TRPV6 function and regulation remain
Ruiqi Cai +13 more
semanticscholar +4 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Years before the emergence of infarctions or significant cognitive decline, patients with cerebral small vessel disease (SVD) show a deterioration in the ability of the brain to augment blood flow locally in response to increases in neuronal
Fabrice Dabertrand +7 more
semanticscholar +1 more source
Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface
bioRxiv, 2022 PLCβs catalyze the hydrolysis of PIP2 into IP3 and DAG. PIP2 regulates the activity of many membrane proteins, while IP3 and DAG lead to increased intracellular Ca2+ levels and activate PKC, respectively.
M. Falzone, R. MacKinnon
semanticscholar +1 more source