Results 21 to 30 of about 58,639 (259)
Neuron, 2007 The function of inwardly rectifying K+ (Kir) channels is highly diverse and therefore is tightly regulated by various environmental factors. In their article in this issue of Neuron, Rapedius et al. recognize a conserved structural mechanism for Kir channels gating by both pH and PIP2.
Guy-David, Liora, Reuveny, Eitan
openaire +2 more sources
Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP2 homeostasis
Molecular Biology of the Cell, 2022 Homeostatic regulation of plasma membrane (PM) phosphatidylinositol 4,5-bisphosphate (PIP2) in receptor-stimulated cells is mediated by the lipid transfer protein Nir2.
C. G. Quintanilla, Wan-Ru Lee, J. Liou
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance The SK4 K+ channel is a member of the family of Ca2+-activated K+ channels exclusively activated by calcified calmodulin (CaM) and is expressed in immune cells, brain, and heart. Here, we show that phosphatidylinositol 4-5 bisphosphate (PIP2)
S. Burg +14 more
semanticscholar +1 more source
Communications Biology, 2022 The plasmalemmal norepinephrine transporter (NET) regulates cardiovascular sympathetic activity by clearing extracellular norepinephrine in the synaptic cleft.
D. Luethi +20 more
semanticscholar +1 more source
Inhibition of the proton-activated chloride channel PAC by PIP2
bioRxiv, 2022 Proton-Activated Chloride (PAC) channel is a ubiquitously expressed pH-sensing ion channel that regulates endosomal acidification and macropinosome shrinkage by releasing chloride from the organelle lumens.
Ljubica Mihaljević +4 more
semanticscholar +1 more source
Insights into Activation Mechanisms of Store-Operated TRPC1 Channels in Vascular Smooth Muscle. [PDF]
, 2020 In vascular smooth muscle cells (VMSCs), the stimulation of store-operated channels (SOCs) mediate Ca2+ influx pathways which regulate important cellular functions including contraction, proliferation, migration, and growth that are associated with the ...
Albert, AP +3 more
core +1 more source
PIP2 Improves Cerebral Blood Flow in a Mouse Model of Alzheimer’s Disease
Function, 2021 Alzheimer’s disease (AD) is a leading cause of dementia and a substantial healthcare burden. Despite this, few treatment options are available for controlling AD symptoms.
A. Mughal +4 more
semanticscholar +1 more source
Divalent Cation-Induced PIP2 Clustering in Cholesterol-Containing Membranes: How PIP2 Lateral Distribution affects PIP2-Gelsolin Interaction [PDF]
Biophysical Journal, 2013 Phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2) is involved in many important cellular events, but the mechanism by which this relatively rare lipid selectively regulates specific proteins is unclear. While many proteins bind to PIP2 with similar affinities in vitro, only a small subset interact with PIP2 at specific sites during specific cellular ...
Wang, Yu-Hsiu, Janmey, Paul A.
openaire +1 more source
eLife, 2022 High-voltage-activated Ca2+ (CaV) channels that adjust Ca2+ influx upon membrane depolarization are differentially regulated by phosphatidylinositol 4,5-bisphosphate (PIP2) in an auxiliary CaV β subunit-dependent manner.
Cheon-Gyu Park +2 more
doaj +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source