Design, synthesis and biological evaluation of 1,3-dihydroxyxanthone derivatives: Effective agents against acetylcholinesterase [PDF]
, 2017 The present work concerns the rational design and development of new inhibitors of acetylcholinesterase (AChE) based on the privileged xanthone scaffold.
Accordino, Sebastian Roberto +5 more
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Advanced Science, EarlyView.The rational design of Ni3+‐rich active sites on nickel nitride nanosheets via Pd‐induced electronic modulation, which was employed in the electrooxidation of sterol coupled with H2 production in a large flow electrolyzer. This work offers a novel strategy for the design and synthesis of highly efficient electrocatalysts and electrolyzers toward the ...
Suiqin Li +11 more
wiley +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C26H31N3O2S, crystallizes with two molecules (A and B) in the asymmetric unit. In each case, the piperidine ring exists in a twist-boat conformation.
T. Mohandas +5 more
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Modulation of Tau Protein Neurotoxic Hallmarks by Novel σ1R Agonists/HDAC Inhibitor Dual‐Acting Compounds [PDF]
ChemMedChemThis study explores the development of dual‐acting compounds combining σ1R agonists and histone deacetylase inhibitors (HDACi). Key findings include compound 2d and 3a's high affinity for σ1R and favorable pharmacokinetic profile and an in vivo determined σ1R agonist profile by reversing the effect of the σ1R antagonist BD‐1063.
Fallica A +16 more
europepmc +2 more sources
A Native Hymenopteran Predator of \u3ci\u3eAgonopterix Alstroemeriana\u3c/i\u3e (Lepidoptera: Oecophoridae) in East-Central Illinois [PDF]
, 2018 Agonopterix alstroemeriana is a European oecophorid moth that defoliates poison hemlock (Conium maculatum), a noxious Eurasian weed extensively naturalized throughout temperate Australia, New Zealand, North America, and South America.
Berenbaum, May R +2 more
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Synthesis of dihydropyridine and piperidine derivatives via an unexpected reaction of pyridine with acetyl chloride [PDF]
, 2013 Acetyl chloride reacts with pyridine to give a mixture of N-acetyl-1,4- and 1,2-dihydropyridyl acetic acid (1a,b) after water quenching. The reactioninvolves the formation of a zwitterionic ketene enolate intermediate which results from deprotonation of
Mannu, Alberto +2 more
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Correlations between electrochemical behaviors and DNA photooxidative properties of non-steroïdal anti-inflammatory drugs and their photoproducts [PDF]
, 2012 Alkali-labile lesion to DNA photosensitized, via an electron transfer mechanism, by three non-steroidalanti-inflammatorydrugs (NSAIDs), ketoprofen, tiaprofenic acid and naproxen and their photoproducts during drug photolysis, was investigated using 32P ...
Chouini-Lalanne, Nadia +6 more
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Angewandte Chemie, EarlyView.We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp +12 more
wiley +1 more source
Concise and Straightforward Asymmetric Synthesis of a Cyclic Natural Hydroxy-Amino Acid
Molecules, 2014 An enantioselective total synthesis of the natural amino acid (2S,4R,5R)-4,5-di-hydroxy-pipecolic acid starting from D-glucoheptono-1, 4-lactone is presented.
Mario J. Simirgiotis +3 more
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Sonogashira/N-acyliminium ion aromatic π-cyclisation processes: access to tetra- and pentacyclic lactams [PDF]
, 2008 Application of the Sonogashira reaction of N-alkynylimides with 2-iodophenol or 2-iodo-N-tosylaniline affords 2-(N-alkylimino)-benzofurans and indoles in good yield.
Grigg, R., Sridharan, V., Sykes, D.A.
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