Results 91 to 100 of about 24,581 (324)
Advanced Science, EarlyView.A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li +13 more
wiley +1 more source
Design, Synthesis, and Structural Evolution of Pseudo‐Natural Product IDO1 Inhibitors and Degraders
Angewandte Chemie, EarlyView.The combination of bicyclic monoterpene‐ and pyrrolidine‐alkaloid fragments yields novel pseudo‐natural products. Biological characterization revealed that these iDegs are inhibitors and degraders of indoleamine‐2,3‐dioxygenase. Abstract Terpenoid alkaloids are derived from the fusion of structurally diverse terpenoid‐ and alkaloid moieties.
Xiu‐Fen Cheng +19 more
wiley +2 more sources
A Most Unusual Zeolite Templating: Cage to Cage Connection of One Guest Molecule [PDF]
, 2010 An unusual case of a diquaternary ammonium dication, with large bulky end groups built from the tropane moiety and connected by a C4 methylene chain, is found to reside in zeolite SSZ-35 (STF).
Burton, Allen W. +6 more
core +1 more source
Replacing Helper Lipids With Cationic Lipids Enhances mRNA Lipid Nanoparticles Stability in Solution
Advanced Science, EarlyView.Partial Replacement of phospholipid lipid by cationic lipid improves storage stability of commercial mRNA LNPs by stabilizing their internal microstructure. Abstract Messenger RNA lipid nanoparticles (mRNA‐LNPs) have achieved remarkable success in clinical vaccination efforts to curb the COVID‐19 pandemic, and have attracted tremendous interest from ...
Rui Chen +8 more
wiley +1 more source
Plasmonic Hot‐Carrier Redox Enables Proton‐Coupled Electron Transfer at C─H Bonds
Angewandte Chemie, EarlyView.Plasmonic hot carriers provide unprecedented control over coupled electron–proton transfer, enabling visible‐light activation of strong C─H bonds. Using an energy‐filter electrode, we reveal a stepwise electron‐then‐proton pathway and directly tune the underlying driving forces.
Daniel Velev Latchev +3 more
wiley +2 more sources
BMC Pharmacology and Toxicology, 2018 Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules.
Moses N. Ngemenya +5 more
doaj +1 more source
Advanced Science, EarlyView.Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu +8 more
wiley +1 more source
Acid‐ and Nucleophile‐Gated Photoisomerization of Phosphaindirubin
Angewandte Chemie, EarlyView.Triply gated isomerization: In polar solvents, a phosphorus‐containing indirubin photoswitch undergoes visible‐light‐driven Z→E isomerization only when protonated, and reverts thermally via nucleophile‐catalyzed back‐isomerization. This three‐way control by light, acid, and nucleophile enables reversible photoisomerization.
Jacob Jan van der Wal +8 more
wiley +2 more sources
Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines
Advanced Science, EarlyView.Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira +18 more
wiley +1 more source
Peptide Sequence Programmed Piezoelectric Response by Supramolecular Self‐Assembly
Advanced Science, EarlyView.In this study, hydrophobic tripeptides are explored as building blocks for stable piezoelectric crystals. Tripeptides with phenylalanine at the central position self‐assembled into uniform, thermally stable crystals. Piezoresponse force microscopy reveals a high effective piezoelectric coefficient of 24.0 pC N−1, attributed to asymmetric molecular ...
Xuejiao Yang +6 more
wiley +1 more source