Results 91 to 100 of about 23,915 (334)

N-substituted-piperidines as Novel Anti-alzheimer Agents: Synthesis, antioxidant activity, and molecular docking study

Future Journal of Pharmaceutical Sciences, 2018
Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described.
Khairia M. Youssef, Iten M. Fawzy, Hussein I. El-Subbagh   +2 more
doaj   +1 more source

Base-catalyzed reactions of environmentally relevant N-chloro-piperidines. A quantum-chemical study [PDF]

, 2011
Electronic structure methods have been applied to calculate the gas and aqueous phase reaction energies for base-induced rearrangements of N-chloropiperidine, N-chloro-3-(hydroxymethyl)piperidine, and N-chloro-4-4-fluorophenyl)-3-(hydroxymethyl ...
Sakic, Davor, Vrcek, Valerije, Zipse, Hendrik   +2 more
core   +1 more source

Suppressing Ion Migration in Heterostructure Single Crystals for Highly Sensitive Ultra‐Stable X‐Ray Detection

Advanced Science, EarlyView.
This work reports a 2D heterostructure single crystal composed of two distinct inorganic frameworks, of which the ion migration is effectively inhibited by the strong interaction between organic components and inorganic layers. Such merits enable highly sensitive ultra‐stable X‐ray detection performances and highlight the potential of heterostructure ...
Yu Ma, Wenjing Li, Yi Liu, Wuqian Guo, Haojie Xu, Liwei Tang, Qingshun Fan, Linjie Wei, Junhua Luo, Zhihua Sun   +9 more
wiley   +1 more source

Identification of a Pair of Linear or Cyclic Naturally Inspired Bifunctional Lipopeptide Antibiotics That Overcome Antimicrobial Resistance

Advanced Science, EarlyView.
The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley   +1 more source

An Elegant Method of One‐Pot Ligation‐Desulfurization for High‐Yielding Chemical Protein Synthesis

Advanced Science, EarlyView.
A one‐pot native chemical ligation and desulfurization method has been developed for efficient chemical protein synthesis. This unique approach uses bromoacetamide and N‐acetyl cysteine to selectively quench arylthiol post native chemical ligation.
Vishal Malik, Abhisek Kar, Anandh Muthiah Venkatachalam, Kalyaneswar Mandal   +3 more
wiley   +1 more source

Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling. [PDF]

, 2015
Alkyl oxalates are new bench-stable alcohol-activating groups for radical generation under visible light photoredox conditions. Using these precursors, the first net redox-neutral coupling of tertiary and secondary alcohols with electron-deficient ...
Jamison, Christopher R, MacMillan, David WC, Nawrat, Christopher C, Overman, Larry E, Slutskyy, Yuriy   +4 more
core  

Synthesis and Kinetic Resolution of Substituted Tetrahydroquinolines by Lithiation then Electrophilic Quench [PDF]

, 2017
Treatment of N-Boc-2-aryl-1,2,3,4-tetrahydroquinolines with n-butyllithium in THF at −78 °C resulted in efficient lithiation at the 2-position and the organolithiums were trapped with a variety of electrophiles to give substituted products.
Aeyad, Affortunato, Ahlbrecht, Anderson, Bailey, Becke, Boche, Capriati, Capriati, Chen, Cochrane, Cochrane, Coldham, Coldham, Coldham, Coldham, Cossi, Das, Davidson, Dieltiens, Du, Fochi, Forero, Grimme, Hodgson, Hopkins, Hoppe, Kang, Kells, Kise, Kong, Kreituss, Kreituss, Kroesen, Lackner, Leth, Li, Li, Lim, Liu, McLean, Mori, Murray, Peters, Raghavachari, Robinson, Saito, Scalmani, Shahane, Sheikh, Sridharan, Stead, Talk, Tatic, Wang, Wang, Wen, Yang, Zhang, Zhang, Zhou, Zhu   +61 more
core   +1 more source

Enantioselective Alkoxycarbonyl‐Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis

Advanced Science, EarlyView.
A highly enantioselective alkoxycarbonyl‐lactonization of alkenes is reported through a photoredox/copper dual‐catalyzed alkoxycarbonyl radical addition/cyclization reaction. Abstract The synthesis of ester derivatives represents one of the most significant and fundamental tasks in modern organic chemistry, and numerous methods have been developed in ...
Yuping Xiong, Zhipeng Zong, Wenlin Xie, Jian‐Qiang Chen, Xiaoyu Zhou, Jie Wu   +5 more
wiley   +1 more source

Prins fluorination cyclisations: Preparation of 4-fluoro-pyran and -piperidine heterocycles

Beilstein Journal of Organic Chemistry, 2010
The Prins reaction was investigated using BF3·OEt2 as a Lewis acid. It has been recently demonstrated, that if BF3·OEt2 is used in stoichiometric amounts then these reactions generate fluorinated products where the BF3·OEt2 contributes fluoride ion to ...
Guillaume G. Launay, Alexandra M. Z. Slawin, David O'Hagan   +2 more
doaj   +1 more source

Pentannulation of N-heterocycles by a tandem gold-catalyzed [3,3]-rearrangement/Nazarov reaction of propargyl ester derivatives: a computational study on the crucial role of the nitrogen atom

Beilstein Journal of Organic Chemistry, 2020
The tandem gold(I)-catalyzed rearrangement/Nazarov reaction of enynyl acetates in which the double bond is embedded in a piperidine ring was computationally and experimentally studied.
Giovanna Zanella, Martina Petrović, Dina Scarpi, Ernesto G. Occhiato, Enrique Gómez-Bengoa   +4 more
doaj   +1 more source