Results 111 to 120 of about 23,915 (334)

A Versatile Near‐Infrared Fluorescent Probe for Fast Assessment of Lysosomal Status via a Large Multimodal Model

Aggregate, EarlyView.
Herein, we report a quinolinium‐based fluorescent probe, PA‐2, for near‐infrared super‐resolution imaging of lysosomal dynamics. Building on this, we next introduce a novel approach leveraging a large multimodal model (LMM), an advanced artificial intelligence tool, for automated image interpretation.
Rui Chen, Eugene Lee, Yuxin Wang, Aditya Yadav, Minling Zhong, Pragti, Yujie Sun, Jiajie Diao   +7 more
wiley   +1 more source

Distance‐Dependence of Photo‐CIDNP in Biomimetic Tryptophan–Flavin Diads

Angewandte Chemie, EarlyView.
NMR and MRI are crucial in sciences, but their low sensitivity limits their use. Photochemically induced dynamic nuclear polarization (photo‐CIDNP) offers a solution. This study explores structure‐photo‐CIDNP relationships in liquid‐state NMR using biomimetic tryptophan–flavin diads with varying oligoproline linker lengths.
Tobias Theiss, Guzel Musabirova, Luca Gerhards, Irina S. Anisimova, Ben G. E. Zoller, Thi Ngoc Ha Nguyen, Dmitry Denisov, Anton Schmidt, Sabrina Panter, Stefan Weber, Christoph Tegenkamp, Ilia A. Solov'yov, Jörg Matysik, Tanja Gulder   +13 more
wiley   +2 more sources

N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis [PDF]

, 2016
Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU “Substances of Very High Concern” list ...
Farmer, Thomas James, Hunt, Andrew John, Moonen, Kristof, Parker, Helen Louise, Sherwood, James Richard   +4 more
core   +1 more source

A Straightforward Access to Enantiopure 4‐Hydroxy‐pipecolic Acid Peptidomimetics by aza‐Prins Cyclization/LiNTf2‐Promoted Aminolysis of Lactones

Asian Journal of Organic Chemistry, EarlyView.
Enantiopure constrained pseudodipeptides based on pipecolic acid scaffold are obtained by a two‐step synthesis involving an aza‐Prins cyclization to deliver piperidine‐lactones, followed by LiNTf2‐promoted aminolysis with various amino acids. Abstract Peptidomimetics, that can take advantage of bioavailability and metabolic stability, are considered as
Vianney Durel, Myriam Le Roch, Jacques Renault, Vincent Dorcet, Thierry Roisnel, Nicolas Gouault, Gilles Argouarch, Claudia Lalli   +7 more
wiley   +1 more source

Radical Borylation of Alkyl Bromides by Photoinduced Halogen‐Atom Transfer

Angewandte Chemie, EarlyView.
The photoinduced borylation of alkyl bromides via halogen atom transfer is reported. The utility of this strategy is demonstrated with broad functional group tolerance in the borylation of various primary, secondary, and tertiary alkyl bromides. Computational studies provide mechanistic insights into the radical‐chain pathway.
Cullen R. Schull, Matthew J. McGill, Ángel Renteria‐Gómez, Poulami Mukherjee, Samuel B. Tyndall, Aaron H. Shoemaker, Michael R. Wasielewski, Osvaldo Gutierrez, Karl A. Scheidt   +8 more
wiley   +2 more sources

Diastereoselective synthesis of some novel benzopyranopyridine derivatives

Beilstein Journal of Organic Chemistry, 2006
BackgroundThe formation of novel N-substituted-1,2,3,4-tetrahydro[1,3]-dioxolo-[6,7]-5H-[1]benzopyrano [3,4-c]pyridines were observed unexpectedly during the acid-mediated ketal removal of ethylenedioxy ketal protected 4-piperidones.
Pradeep K. Mohakhud, Sujeet M. R. Kumar, Vasanth M. R. Kumar, Ravi M. R. Kumar, Moses D. R. Babu, Vyas D. R. K, Om D. R. Reddy   +6 more
doaj   +1 more source

Synthesis of N‐Substituted 4‐Pyridones From Skipped Diynones via Intramolecular Base or Ag(I)‐Catalyzed Hydroamination

Asian Journal of Organic Chemistry, EarlyView.
A general protocol for the synthesis of N‐substituted 4‐pyridones from skipped diynones is presented via a base or Ag(I)‐catalyzed hydroamination pathway. Abstract Cs2CO3 or CF3COOAg catalyze the intramolecular 6‐endo hydroamination of the Z‐enaminones derived from the Michael‐type addition of primary amines to skipped diynones, yielding N‐substituted ...
Elisavet‐Maria Zantioti‐Chatzouda, Stavroula‐Aikaterini Kaplani, Eleni‐Maria Stroda, Nikolaos Eleftheriadis, Manolis Stratakis   +4 more
wiley   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

N‐Amino Peptide–Graphene Quantum Dot Loaded Small Extracellular Vesicles for Targeted Therapy of Tauopathies

Advanced NanoBiomed Research, EarlyView.
A neuron‐targeting drug delivery system is developed by incorporating the tau‐specific N‐amino peptide, mxyl‐NAP2, with graphene quantum dots (GQDs) and encapsulating the complex into small extracellular vesicles functionalized with a neuron‐targeting ligand.
Runyao Zhu, Gaeun Kim, Benjamin H. Rajewski, Isaac J. Angera, Juan R. Del Valle, Yichun Wang   +5 more
wiley   +1 more source

A Fluorogenic Hydrazino‐Pictet–Spengler Reaction in Live Cells

Angewandte Chemie, EarlyView.
A fluorogenic hydrazino‐Pictet–Spengler (HIPS) ligation reaction is used to label lipid‐derived aldehydes under wash‐free conditions in live cells. This innovative technique enables wash‐free imaging within biological systems, offering invaluable insights into the extent and localization of oxidative stress.
Kaleena Basran, Nathan W. Luedtke
wiley   +2 more sources