Results 111 to 120 of about 47,089 (385)

Transaminase triggered aza-Michael approach for the enantioselective synthesis of piperidine scaffolds [PDF]

open access: yes, 2016
The expanding “toolbox” of biocatalysts opens new opportunities to redesign synthetic strategies to target molecules by incorporating a key enzymatic step into the synthesis.
Andrew Gomm   +6 more
core   +3 more sources

Identification of a Pair of Linear or Cyclic Naturally Inspired Bifunctional Lipopeptide Antibiotics That Overcome Antimicrobial Resistance

open access: yesAdvanced Science, EarlyView.
The underexplored bacterial genus Aquimarina harbors a large biosynthetic potential for discovering new antibiotics. Here, the authors identify a pair of linear or cyclic bifunctional cationic lipopeptide antibiotics, aquicidine L and C4, inspired by the aquicidine gene cluster from Aquimarina.
Lei Li, Yiwen Zhou, Yuzhu Wu
wiley   +1 more source

Influence of Organic Structure Directing Agent Isomer Distribution on the Synthesis of SSZ-39 [PDF]

open access: yes, 2015
The aluminosilicate molecular sieve with the AEI framework topology (SSZ-39) is currently of great interest for use in a number of important applications such as exhaust gas NO_x reduction and the methanol-to-olefins reaction.
Davis, Mark E.   +5 more
core   +2 more sources

Enantioselective Alkoxycarbonyl‐Lactonization of Alkenes via the Merger of Photoredox and Copper Catalysis

open access: yesAdvanced Science, EarlyView.
A highly enantioselective alkoxycarbonyl‐lactonization of alkenes is reported through a photoredox/copper dual‐catalyzed alkoxycarbonyl radical addition/cyclization reaction. Abstract The synthesis of ester derivatives represents one of the most significant and fundamental tasks in modern organic chemistry, and numerous methods have been developed in ...
Yuping Xiong   +5 more
wiley   +1 more source

Structurally simple synthetic 1, 4-disubstituted piperidines with high selectivity for resistant Plasmodium falciparum

open access: yesBMC Pharmacology and Toxicology, 2018
Background Emergence of resistance to artemisinins and some of their combinations in chemotherapy of clinical malaria has intensified the search for novel safe efficacious antimalarial molecules.
Moses N. Ngemenya   +5 more
doaj   +1 more source

Dynamics and Catalytic Resolution of Selected Chiral Organolithiums [PDF]

open access: yes, 2011
One of the most important developments of the last decade has been the emergence of new methods to dynamically resolve racemic organolithiums using stoichiometric amounts of the chiral ligand.
Beng, Timothy Kum
core   +1 more source

A Multifunctional Molecular Probe for Multimodal Imaging‐Guided Potent Photothermal/Photodynamic Therapy of Endometriosis

open access: yesAdvanced Science, EarlyView.
The cRGD‐ILD molecular probe integrates clinically available components: a cRGD peptide (integrin αvβ3 targeting), ICG (for fluorescence/photoacoustic imaging and phototherapy), and Gd‐DTPA (MRI contrast). Utilizing small size and receptor targeting, it achieves selective lesion accumulation.
Qiyu Zhong   +9 more
wiley   +1 more source

A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids

open access: yesAdvanced Science, EarlyView.
A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Huiling Liu   +8 more
wiley   +1 more source

Silylative Amide to Nitrile Conversion Mediated by Simple Lanthanide–Organoamides: Scope and Mechanism

open access: yesAngewandte Chemie, EarlyView.
Described here is a LaNTMS mediated silylative conversion of primary amides to nitriles under neat reaction conditions. The reaction is highly efficient and selective under such solventless conditions, where all materials are commercially available, demonstrating the robustness and potential of lanthanide heteroatom catalysis.
Zhiyu Feng   +5 more
wiley   +2 more sources

Molecular Engineering of Layered Halide Double Perovskites: Challenges and Opportunities in Optoelectronics and Beyond

open access: yesAdvanced Energy Materials, EarlyView.
Layered halide double perovskites have emerged as promising alternatives to toxic lead‐based low‐dimensional perovskite materials for more sustainable optoelectronics. Their molecular design and its impact on the material characteristics, as well as the resulting functionality, is reviewed while discussing challenges and opportunities for future ...
Maryam Ghasemi   +4 more
wiley   +1 more source

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