Results 111 to 120 of about 24,581 (324)
Synthesis and Kinetic Resolution of Substituted Tetrahydroquinolines by Lithiation then Electrophilic Quench [PDF]
, 2017 Treatment of N-Boc-2-aryl-1,2,3,4-tetrahydroquinolines with n-butyllithium in THF at −78 °C resulted in efficient lithiation at the 2-position and the organolithiums were trapped with a variety of electrophiles to give substituted products.
Aeyad +61 more
core +1 more source
Copper‐Catalyzed Three‐Component Selective 1,4‐Amino Oxygenation of 1,3‐Dienes
Angewandte Chemie, EarlyView.Enclosed is a copper‐catalyzed selective 1,4‐amino oxgenation of 1,3‐dienes with the presence of a strong Brønsted acid. This three‐component transformation offers a novel and powerful approach to construct (E)‐1,4‐allylic amino oxygenated motifs by the simultaneous installation of structurally diverse alkylamines and alcohols directly onto 1,3‐dienes.
Guangshou Feng +2 more
wiley +2 more sources
InorganicsTreatment of N,N-dimethylhydrazinoalkenes with diethylzinc followed by exposure of the resulting ethylzinc amides to high vacuum drives a Schlenck redistribution metalloamination/cyclization to generate the corresponding bis(organozinc) intermediates in ...
Jérome Lépeule +2 more
doaj +1 more source
New One-Pot Methodologies for the Modification or Synthesis of Alkaloid Scaffolds
Marine Drugs, 2010 There are several avenues by which promising bioactive natural products can be produced in sufficient quantities to enable lead optimization and medicinal chemistry studies. The total synthesis of natural products is an important, but sometimes difficult,
Amir E. Wahba, Mark T. Hamann
doaj +1 more source
Angewandte Chemie, EarlyView.A complexity‐generating intramolecular alkene diamination constitutes the pivotal step in the enantioselective synthesis of the title natural products featuring a strained, cage‐like pentacyclic architecture. Abstract Among more than four thousand monoterpene indole alkaloids (MIAs) isolated to date, only a few feature a 2,2,3‐trisubstituted indoline ...
Vincent Goëlo, Qian Wang, Jieping Zhu
wiley +2 more sources
N-Butylpyrrolidinone as a dipolar aprotic solvent for organic synthesis [PDF]
, 2016 Dipolar aprotic solvents such as N-methylpyrrolidinone (or 1-methyl-2-pyrrolidone (NMP)) are under increasing pressure from environmental regulation. NMP is a known reproductive toxin and has been placed on the EU “Substances of Very High Concern” list ...
Farmer, Thomas James +4 more
core +1 more source
The EVA spectral descriptor [PDF]
, 2000 The EVA descriptor is derived from fundamental IR- and Raman range molecular vibrational frequencies. EVA is sensitive to 3D structure but has an advantage over field-based 3D-QSAR methods inasmuch as it is invariant to both translation and rotation of ...
Turner, D.B., Willett, P.
core +1 more source
Opportunities and challenges for direct C–H functionalization of piperazines
Beilstein Journal of Organic Chemistry, 2016 Piperazine ranks within the top three most utilized N-heterocyclic moieties in FDA-approved small-molecule pharmaceuticals. Herein we summarize the current synthetic methods available to perform C–H functionalization on piperazines in order to lend ...
Zhishi Ye, Kristen E. Gettys, Mingji Dai
doaj +1 more source
Angewandte Chemie, EarlyView.Dieser Mini‐Review behandelt die neuesten Fortschritte bei der Synthese, Reaktivität und metallfreien katalytischen Verwendung von mesoionischen N‐heterocyclischen Olefinen (mNHOs), Iminen (mNHIs), Thionen (mNHTs) und Phosphinidenen (mNHPs). Kurzzusammenfassung Übergangsmetallverbindungen sind allgemein für ihre Fähigkeit bekannt, kleine Moleküle zu ...
Subir Maji +3 more
wiley +1 more source
Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation
, 2014 A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3–sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step.
Despiau, Carole F. +3 more
core +2 more sources