Results 121 to 130 of about 47,089 (385)
Angewandte Chemie, EarlyView.By modifying ring size and exocyclic substituents, effects of ligand interlocking on metal coordination features is explored. Through systematic analysis of CuI catenanes, relationship between structural parameters of the interlocked ligands and coordination properties like geometry, stability, and reactivity is established.
Yulin Deng +8 more
wiley +2 more sources
Future Journal of Pharmaceutical Sciences, 2018 Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining carbamoylpiperidine analogs containing nipecotic acid scaffold were described.
Khairia M. Youssef +2 more
doaj +1 more source
The EVA spectral descriptor [PDF]
, 2000 The EVA descriptor is derived from fundamental IR- and Raman range molecular vibrational frequencies. EVA is sensitive to 3D structure but has an advantage over field-based 3D-QSAR methods inasmuch as it is invariant to both translation and rotation of ...
Turner, D.B., Willett, P.
core +1 more source
Strategies for Paired Electrolysis with Enhanced Efficiency
Advanced Energy and Sustainability Research, EarlyView.This review summarizes the fundamentals, challenges, and strategies for paired electrolysis, with examples in the chlor‐alkali, hydrogen production, CO2 reduction, and ammonia synthesis industries. Future directions include the development of advanced membranes, computational studies, process integration, scale‐up, and techno‐economic analysis.
Yuanyuan Yao +6 more
wiley +1 more source
Angewandte Chemie, EarlyView.An electrochemical α‐C─H functionalization of nitramines enables the synthesis of molecules containing bifunctional energetic heterocycles with promising properties. A telescoped, HNO3‐free sequence involving nitration and azolation steps offers a safer, modular, and scalable platform for the synthesis of energetic compounds.
Wan‐Chen Cindy Lee +4 more
wiley +2 more sources
Studies on the C-C Bond Formation Methods Based on the Activation of Secondary Amides and the Asymmetric Total Synthesis of Cylindricine D [PDF]
, 2016 有机合成方法学和天然产物全合成是有机化学的两个重要分支，直接推动并促进有机化学及药物研发等相关学科领域的发展。 本论文包含两方面的工作，一是发展基于仲酰胺活化形成C–C键方法学的研究，二是拓展叔酰胺一瓶双烷基化构筑N-杂季碳的方法学应用到Cylindricine类生物碱的不对称合成研究。 酰胺是一类重要的有机合成和药物合成中间体，也构成了蛋白质的主要结构特征。此外，酰胺基常用作胺的保护基、C–H活化反应的活化定位基团。然而，酰胺高度稳定，羰基的反应活性非常低。因此 ...
黄应红
core
Synthesis and Kinetic Resolution of Substituted Tetrahydroquinolines by Lithiation then Electrophilic Quench [PDF]
, 2017 Treatment of N-Boc-2-aryl-1,2,3,4-tetrahydroquinolines with n-butyllithium in THF at −78 °C resulted in efficient lithiation at the 2-position and the organolithiums were trapped with a variety of electrophiles to give substituted products.
Aeyad +61 more
core +1 more source
Asian Journal of Organic Chemistry, EarlyView.Enantiopure constrained pseudodipeptides based on pipecolic acid scaffold are obtained by a two‐step synthesis involving an aza‐Prins cyclization to deliver piperidine‐lactones, followed by LiNTf2‐promoted aminolysis with various amino acids. Abstract Peptidomimetics, that can take advantage of bioavailability and metabolic stability, are considered as
Vianney Durel +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld +23 more
wiley +2 more sources