Results 141 to 150 of about 24,641 (321)

Designing chemical systems for precision deuteration of medicinal building blocks

Nature Communications
Methods are lacking that can prepare deuterium-enriched building blocks, in the full range of deuterium substitution patterns at the isotopic purity levels demanded by pharmaceutical use.
Jonathan D. Dabbs, Caleb C. Taylor, Martin S. Holdren, Sarah E. Brewster, Brian T. Quillin, Alvin Q. Meng, Diane A. Dickie, Brooks H. Pate, W. Dean Harman   +8 more
doaj   +1 more source

Synthesis, Structural Characterization, In Vitro and In Silico Evaluations of Piperidine Carbodithioates as New Azole Antifungal Agents [PDF]

Saeed Emami, Elham Ghobadi, Seyedeh Mahdieh Hashemi, Maryam Darabi, Hamed Fakhim, Morteza Ghandadi, Zahra Hosseini‐khah, Hamid Badali   +7 more
openalex   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Conversion of 3-Substituted Piperidines and Pyridines into the Corresponding N-(3,4-Dimethoxyphenethyl)lactams: A Comparative Study of the Mercuric Acetate-EDTA and the Ferricyanide Oxidation Methods

, 1975
Tozo Fujii, Masashi Ohba, Shigeyuki Yoshifuji   +2 more
openalex   +1 more source

Asymmetric α-amidoalkylation. Synthesis of α-substituted piperidines of high enantiomeric purity [PDF]

, 1987
Kärtner, Annerose, Wanner, Klaus Th.
core   +1 more source

Residual Chemical Shift Anisotropies in the Structure Determination of Small Molecules

Magnetic Resonance in Chemistry, EarlyView.
Plasma neutrophil elastase(ELANE) was markedly elevated in patients with alcohol use disorder, indicating a dysregulated protease‐antiprotease inflammatory balance characterised by decreased SERPINA3. ELANE showed excellent diagnostic specificity(AUC = 0.8683), supporting its potential utility as a neuroinflammatory biomarker for AUD.
Nilamoni Nath, Juan Carlos Fuentes Monteverde, Swaraj Pathak, Christian Griesinger   +3 more
wiley   +1 more source

Piperidines [PDF]

Chemical & Engineering News Archive, 1978
openaire   +1 more source

Synthesis and receptor binding studies of novel 4,4-disubstituted arylalkyl/arylalkylsulfonyl piperazine and piperidine-based derivatives as a new class of σ1 ligands

, 2013
Masoud Sadeghzadeh, Shahab Sheibani, Mehdi Ghandi, Fariba Johari Daha, Massoud Amanlou, Mohammad Arjmand, Abolfazl Hasani Bozcheloei   +6 more
openalex   +1 more source

Кванто-механические исследования молекулярных комплексов p-хлоранила с пиперидином, анилином и их производными [PDF]

, 2018
В настоящей работе мы провели сравнение экспериментальных данных адиабатических и вертикальных потенциалов ионизации молекулярных комплексов p-хлоранила с пиперидином, анилином и их производными с результатами кванто-механических расчётов в программе ...
Rustambek, U.
core  

Synthesis of 1,2,3,4‐Tetrahydroisoquinoline‐3‐Carboxylic Acid‐Embedded Decapeptides: In Silico Studies and In Vitro Evaluation Against Breast Cancer

ChemistryOpen, EarlyView.
Synthesized decapeptides were designed and validated by in silico studies. They have significantly exhibited anticancer potential against breast cancer and MCF‐7 cell line. The above illustration specifies the synthetic pathway, biological screening, and the mode of action of the peptide in blocking the pathways responsible for the growth of cancer ...
Sunil Tivari, Naurin Lalani, Pritam Bagwe, Prashant Chandole, Ramesh Pawar, Enrique Delgado‐Alvarado, Abdallah Othman Ghnaim, Yashwantsinh Jadeja   +7 more
wiley   +1 more source