Results 151 to 160 of about 40,506 (345)

Oxidative Folding of a Two‐Chain Protein Having Three Interchain Disulfide Bonds. Synthesis of Bromelain Inhibitor VI Through Native Chain Assembly

open access: yesChemistry – A European Journal, EarlyView.
Bromelain inhibitor VI, a two‐chain protein stabilized by three interchain SS bonds and two intrachain SS bonds, was synthesized in an incredibly high isolated yield (53%) just by mixing the two native chains in a buffer solution. This success made a record of oxidative protein folding for the most complicated and difficult one.
Michio Iwaoka, Sawa Akaboshi
wiley   +1 more source

Transaminase-Triggered Cascades for the Synthesis and Dynamic Kinetic Resolution of Chiral N-Heterocycles. [PDF]

open access: yesAngew Chem Int Ed Engl
O'Connell A   +10 more
europepmc   +1 more source

Photocatalysis Enables Chemodivergent Radical Polar Crossover: Ritter‐Type Amidation vs Heck‐Type Olefin Carbofunctionalizations

open access: yesChemistry – A European Journal, EarlyView.
One aryl makes the difference: switching styrenes with 1,1‐diaryl olefins as radical acceptors, the benzylic cation intermediate fate changes from Ritter‐type carboamidation to Heck‐type reaction. The decarboxylative photocatalytic chemodivergent methodology enabled broad scope and efficient scalability in both batch and flow.
Mattia Lepori   +5 more
wiley   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

open access: yesChemistry – A European Journal, EarlyView.
This review highlights recent advances in mechanochemical methods for multistep organic synthesis, focusing on sequential one‐pot approaches performed by grinding or ball milling. The presented transformations are discussed in terms of efficiency, applicability, and sustainability, assessing both the challenges and potential of solvent‐free one‐pot ...
Nina Biedermann, Michael Schnürch
wiley   +1 more source

Hypervalent iodine-mediated intramolecular alkene halocyclisation. [PDF]

open access: yesBeilstein J Org Chem
Bansal C   +3 more
europepmc   +1 more source

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