Results 151 to 160 of about 47,089 (385)
Synthesis of N-heterocycles from diamines via H2-driven NADPH recycling in the presence of O2 [PDF]
, 2019 Herein, we report an enzymatic cascade involving an oxidase, an imine reductase and a hydrogenase for the H2-driven synthesis of N-heterocycles.
Al-Shameri, Ammar +5 more
core +1 more source
Design and synthesis of a fragment set based on twisted bicyclic lactams
, 2018 Current fragment sets tend to be dominated by flatter molecules, and their shape diversity does not reflect that of the fragments that are theoretically possible.
Hassan, H, Marsden, S, Nelson, AS
core +1 more source
Angewandte Chemie International Edition, EarlyView.We present a nanodroplet array platform that integrates solid‐phase synthesis, MALDI‐MS analysis, and cell‐based screening. Using nanoliter droplets, we synthesized and tested 325 potential MEK inhibitors and identified 46 active compounds. This miniaturized approach combines chemistry and biology on a single chip, reducing time, cost, and material use
Maximilian Seifermann +10 more
wiley +1 more source
Regulating Promiscuous Catalysis via Substrate‐Induced Transient Assembly
Angewandte Chemie International Edition, EarlyView.We report a novel substrate‐induced transient co‐assembly between a short Lys‐rich peptide and Fmoc‐Gly‐OH. In the activated state, the assembly exhibits promiscuous catalytic activity through the rate enhancements of hydrolysis and C═N condensation reactions.
Ayan Chatterjee +7 more
wiley +1 more source
[[alternative]]Designs and Syntheses of Glycosidase Inhibitors and Analogues from D-Quinic Acid [PDF]
計畫編號：NSC92-2113-M032-004研究期間：200308~200407研究經費：827,000[[sponsorship ...
施增廉
core
5-Hydroxy-Piperidine-2-Carboxylic Acid in Green Plants. [PDF]
, 1954 Artturi I. Virtanen +3 more
openalex +1 more source
Novel Approaches For The Synthesis Of Amino Acids And Piperidines, Including Asymmetric Strategies [PDF]
, 2012 Chapter I deals with novel approaches for α-amino acids. This chapter has been divided into three sections. Section A describes the synthesis of α-amino acids via the Beckmann rearrangement of carboxyl-protected β-keto acid oximes.
Vippila, Mohana Rao
core +1 more source
Total synthesis of (±)-paroxetine by diastereoconvergent cobalt-catalysed arylation
, 2014 A total synthesis of paroxetine is reported, with a diastereoselective and diastereoconvergent cobalt-catalysed sp3–sp2 coupling reaction involving a 3-substituted 4-bromo-N-Boc-piperidine (Boc = tert-butoxycarbonyl) substrate as a key step.
Despiau, Carole F. +3 more
core +2 more sources