Results 201 to 210 of about 24,641 (321)

Novel Sulfonium Reagents for the Modular Synthesis of Spiro[2.3]Hexanes and Heteroatom‐Containing Analogues: Synthesis, Application, and Evaluation as Bioisosteres

Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.
Strained spirocyclic spiro[2.3]hexane and its heteroatom‐containing derivatives, including previously underrepresented 5‐oxa‐1‐azaspiro[2.3]hexanes and 1,5‐diazaspiro[2.3]hexanes, were synthesized via a modular approach of insertion of cyclobutane‐, oxetane‐, and azetidine‐containing sulfonium reagents into alkenes, carbonyls and imines.
Philipp Natho, Annarita Vicenti, Fabrizio Mastrolorito, Francesca De Franco, Lee Walsh‐Benn, Marco Colella, Ernesto Mesto, Emanuela Schingaro, Orazio Nicolotti, Antimo Gioiello, Renzo Luisi   +10 more
wiley   +2 more sources

Novel 3-Aminopyrrolidine and Piperidine Macrocyclic Orexin Receptor Agonists for Treating Sleep Disorders

, 2022
Ram W. Sabnis
openalex   +2 more sources

Conformational dynamics in insulin receptor kinase reveal a type III allosteric pocket

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Allosteric modulation is a promising strategy for selective kinase inhibition, yet structural insights into allosteric pockets remain limited across the human kinome. In this work, we present comprehensive characterization of a type III allosteric pocket in the insulin receptor kinase (IRK), integrating structural, conformational, and ...
Jyoti Verma, Harish Vashisth
wiley   +1 more source

Chiron approaches to polyhydroxylated piperidines: promising glycosidase inhibitors

ARKIVOC, 2002
Dilip D. Dhavale, Vijaya N. Desai, Nabendu N. Saha, Jayant N. Tilekar   +3 more
doaj   +1 more source

"Comprehensive Characterization and Theoretical Validation of a 4-Benzyl Piperidine Derivative with Multi-Targeted Bioactivity "

V. Neuna, J. Maria Libiyal, B. Ravindran Durai Nayagam, Caroline Daisy   +3 more
openalex   +1 more source

A natural barrier: tick‐repellent potential of a spruce‐derived volatile blend against Hyalomma excavatum and Ixodes ricinus

Pest Management Science, Volume 82, Issue 2, Page 1481-1491, February 2026.
Both active and passive questing ticks, Hyalomma excavatum and Ixodes ricinus, were assessed for behavioural responses to two novel plant‐derived repellent volatile organic compound blends. Both tick species were repelled by the products, and both novo blends were significantly more repellent than currently available commercial products.
Martyn J. Wood, Sare I. Yavaşoğlu, James C. Bull, Serkan Bakırcı, Kanagasooriyam Kanagachandran, Tariq M. Butt   +5 more
wiley   +1 more source

Dearomative spirocyclization of ynamides. [PDF]

Chem Sci
Agbaria M, Egbaria N, Nairoukh Z.
europepmc   +1 more source

On‐Resin Pictet–Spengler Cyclization for 1,2,3,4‐Tetrahydro‐β‐carboline‐3‐carboxylate (Tcc) Peptide Synthesis With Acid‐Labile Functional Tolerance

Journal of Peptide Science, Volume 32, Issue 2, February 2026.
The constrained tryptophan (Trp) analog 1,2,3,4‐tetrahydro‐β‐carboline‐3‐carboxylic acid (Tcc) is used to restrict peptide conformation in structure–activity relationship studies. Although Pictet–Spengler cyclization of Trp and aldehydes with mineral acid gives Tcc analogs, such harsh conditions do not tolerate acid‐labile functionality.
Omer S. L. N'dri, Charity D. Yongo‐Luwawa, Xiaozheng Wei, Kajumee Bora Bhowal, Chitra P. Sadanandhan, Darince Truong, Ida Boccino, Will Maclean, Lylia Dif‐Yaiche, Zoé Villeneuve, William D. Lubell   +10 more
wiley   +1 more source

Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(sp³)-H Activation of Lactams. [PDF]

J Am Chem Soc
Lu P, Burgenson WR, Simmons BJ, Liu S, Yeung KS, Qiao JX, Yu JQ.   +6 more
europepmc   +1 more source

The Potential of Piperidine Alkaloids-rich Extracts from Prosopis spp. to Combat Plant Pests and Diseases

, 2022
Carlos Vladimir Muro-Medina, S. García-Morales, Anabel Ortiz, E. Tapia-Campos, Janet María León‐Morales   +4 more
openalex   +2 more sources