Results 201 to 210 of about 47,089 (385)

Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders

ChemMedChem, EarlyView.
A partial proteolysis targeting chimera (PROTAC) library bearing achiral phenyl dihydrouracil cereblon ligands is prepared. It is then applied to the rapid development of a full PROTAC library targeting Bruton's tyrosine kinase, which can be directly used for screening.
Chelsi M. Almodóvar‐Rivera, Ira Tandon, Ramesh Mudududdla, Paulina N. Esguerra, Kevin Lucio‐Acero, Weiping Tang   +5 more
wiley   +1 more source

FOR PIPERIDINES, CONTACT REILLY [PDF]

, 1972

openalex   +3 more sources

Isomerization of N-acyl-1,2,5,6-tetrahydropyridines to N-acyl-enamines by palladium on carbon [PDF]

, 1987
Kärtner, Annerose, Wanner, Klaus Th.
core   +1 more source

Development of Keap1‐Nrf2 Protein–Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene‐2‐acetamide Scaffold, and its Anti‐Inflammatory Effects

ChemMedChem, EarlyView.
Pyrrolidine‐type naphthalene‐2‐acetamide compound 5i inhibits Kelch‐like ECH‐associated protein 1 (Keap1)‐nuclear factor erythroid 2‐related factor 2 (Nrf2) protein–protein interaction by binding to the Keap1‐DC domain; it subsequently activates intracellular Nrf2 and induces Nrf2‐target genes.
Daisuke Yasuda, Kai Toyoshima, Koujin Kojima, Hanako Ishida, Kazuma Kaitoh, Riyo Imamura, Kayoko Kanamitsu, Hirotatsu Kojima, Megumi Funakoshi‐Tago, Masanori Osawa, Tomoyuki Ohe, Tomoya Hirano   +11 more
wiley   +1 more source

AgamOBP1‐Directed Discovery of Repellents to Control the Spread of Mosquito‐Borne Diseases

ChemMedChem, EarlyView.
Toward the discovery of novel mosquito repellents, a library of potential binders of AgamOBP1 (secondary amines) generated from two amines and seven aldehydes was designed aiming to enable interactions with critical amino acids at the DEET‐site and to bridge the DEET‐ and Icaridin sIC‐binding pockets. 1H STD NMR spectroscopy in the presence of AgamOBP1
Evanthia Chazapi, Eftichia Kritsi, Constantinos Potamitis, Panagiota G. V. Liggri, Katerina E. Tsitsanou, Christina E. Drakou, Antonios Michaelakis, Dimitrios P. Papachristos, Spyros E. Zographos, Maria Zervou, Theodora Calogeropoulou   +10 more
wiley   +1 more source

Selective <i>endo</i>-Cyclic α-Functionalization of Saturated <i>N</i>-Alkyl Piperidines. [PDF]

J Org Chem
Phillips RC, Chu JCK, Rafaniello AA, Gaunt MJ.   +3 more
europepmc   +1 more source

Derivatives of eis-NPCl₂(NSOCl)₂ and (NPCl₂)₂NSOCl, Part IX [1] Substitution Reactions of cis-NPCl₂(NSOCl)₂ with Piperidine [PDF]

, 1978
H. H. Baalmann, Ron J. Keizer, J. C. van de Grampel, C. Kruk   +3 more
openalex   +1 more source

Enantioselective Synthesis of α-(Hetero)aryl Piperidines through Asymmetric Hydrogenation of Pyridinium Salts and Its Mechanistic Insights.

Organic Letters, 2018
Bo Qu, Hari P R Mangunuru, Sergei Tcyrulnikov, Daniel Rivalti, O. Zatolochnaya, Dmitry Kurouski, Suttipol Radomkit, Soumik Biswas, Shuklendu D. Karyakarte, K. Fandrick, J. Sieber, S. Rodriguez, J. Desrosiers, N. Haddad, K. McKellop, S. Pennino, Heewon Lee, N. Yee, Jinhua J. Song, Marisa C. Kozlowski, C. Senanayake   +20 more
semanticscholar   +1 more source

Synthesis and Evaluation of Fluorinated Peptidomimetics Enabling the Development of 18F‐Labeled Radioligands Targeting Muscarinic Acetylcholine Receptor Subtype M3

ChemMedChem, EarlyView.
Fluorinated peptidomimetics targeting muscarinic acetylcholine receptor subtype M3: Fluorinated peptidomimetic compounds based on a β‐alanine‐glycine scaffold, with lead compound 24 demonstrating high M3 selectivity and submicromolar potency. The first M3‐selective positron emission tomography radioligand, [18F]24, is synthesized and will be evaluated ...
Miguel A. Herrera‐Rueda, Maxwell A. Boateng, Melinda Wuest, Frederick G. West, Frank Wuest   +4 more
wiley   +1 more source

Stereochemistry in Solution. III. Stereoselectivity in N-Quaternization and N-Oxygenation of α-Substituted Piperidines.

, 1967
Yutaka Kawazoe, Mitsuhiro Tsuda
openalex   +2 more sources