Results 231 to 240 of about 24,581 (324)

Skeletal Editing Strategies Driven by Total Synthesis. [PDF]

Acc Chem Res
Kim SF, Amber C, Bartholomew GL, Sarpong R.   +3 more
europepmc   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

Addiction, EarlyView.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer, Katharina Elisabeth Grafinger, Maren Hermanns‐Clausen, Volker Auwärter   +3 more
wiley   +1 more source

Radical-Polar Crossover Bicyclization Enables a Modular Synthesis of Saturated Bicyclic Amines. [PDF]

Adv Sci (Weinh)
Feng D, Geng X, Zuo L, Li Z, Wang L.
europepmc   +1 more source

Comparison between the effects of (+)3-(3-hydroxy-phenyl) —N-(1-propyl) piperidine ((+)-3-PPP) and other dopaminergic drugs on the cortical EEG of free-moving rabbits

, 1995
Kazushi Yamanouchi, Toshio Ishikawa
openalex   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

A new chiral heterocyclic 1,1-enediamine as a precursor to piperidines

ARKIVOC, 2003
Raymond C. F. Jones, Simon C. Hirst
doaj   +1 more source

Multiple skin tumors in a patient treated with orelabrutinib for mantle-cell lymphoma: Case report. [PDF]

Medicine (Baltimore)
Fu X, Zhang Y, Zeng L, Zhang Q, Fu X.
europepmc   +1 more source

Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-(2-phthalimidoethyl)piperidine, and related derivatives

, 1992
Hachiro Sugimoto, Yutaka Tsuchiya, Hiroyuki Sugumi, Kunizo Higurashi, Norio Karibe, Yoichi Iimura, Atsushi Sasaki, Shin Araki, Yoshiharu Yamanishi, Kiyomi Yamatsu   +9 more
openalex   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

British Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim, Junhyuk Woo, Sungmin Pak, Joonho Paik, Gyu‐Sang Hong, Ji Hun Wi, Sanghee Lee, Cristina Fenollar‐Ferrer, Kyungreem Han, Young Kee Shin, Uhtaek Oh   +10 more
wiley   +1 more source

Anesthetic Management With Remimazolam for Adolescent Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-like Episodes (MELAS): A Case Report. [PDF]

Anesth Prog
Ueda M, Tanaka N, Momota Y, Kawaguchi M.
europepmc   +1 more source