Results 21 to 30 of about 46,002 (241)

Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste

Nature Communications, 2021
1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped.
Bo-Shuai Mu, Xiao-Yuan Cui, Xing-Ping Zeng, Jin-Sheng Yu, Jian Zhou   +4 more
doaj   +1 more source

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

Pharmaceuticals, 2022
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–activity
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens   +13 more
doaj   +1 more source

1-[(3-Nitrophenyl)(piperidin-1-yl)methyl]piperidine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the crystal structure of the title compound, C17H25N3O2, one-dimensional chains are formed via intermolecular C—H...O hydrogen bonds along the a axis.
Zhe-Qin Wang, Yi Ma
openaire   +3 more sources

Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

Molecules, 2012
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl ...
Masashi Uchida, Mitsuko Miyamoto, Mika Kitsukawa, Masafumi Isogaya, Ryoji Hayashi, Kuniaki Kawamura, Takeshi Ishigaki, Yasuhiro Morita, Katsuhiko Iseki   +8 more
doaj   +1 more source

4-[4-(Piperidin-1-yl)piperidin-1-yl]benzonitrile [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(17)H(23)N(3), both piperidine rings adopt chair conformations. In the crystal packing, intermolecular C-H⋯N hydrogen bonds and C-H⋯π interactions are present.
Guo-bin Xu, Jian-you Shi, Li-juan Chen, You-fu Luo   +3 more
openaire   +3 more sources

Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation.

Chem, 2019
Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffler-Freytag (HLF)
Zuxiao Zhang, Xin Zhang, David A. Nagib
semanticscholar   +1 more source

Phenyl piperidine-1-carboxylate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
Dans le composé du titre, C(12)H(15)NO(2), l'angle dièdre entre le cycle benzénique et le plan basal du cycle pipéridine (qui est dans une conformation de chaise) est de 49,55 (8)°. Dans le cristal, les mol-écules sont liées par des liaisons hydrogène C-H 0 et des interactions C-H π très faibles.
Durre Shahwar, Muhammad Nawaz Tahir, Naeem Ahmad, Saif Ullah, Muhammad Akmal Khan   +4 more
openaire   +3 more sources

Electrochemical Aminoxyl-Mediated α-Cyanation of Secondary Piperidines for Pharmaceutical Building Block Diversification.

Journal of the American Chemical Society, 2018
Secondary piperidines are ideal pharmaceutical building blocks owing to the prevalence of piperidines in commercial drugs. Here, we report an electrochemical method for cyanation of the heterocycle adjacent to nitrogen without requiring protection or ...
A. Lennox, Shannon L. Goes, Matthew P. Webster, H. Koolman, S. Djuric, S. Stahl   +5 more
semanticscholar   +1 more source

Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents

Molecules, 2022
Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore, Jérome Lépeule, Tom Livinghouse   +2 more
doaj   +1 more source

Study on Multi Drug Resistant Opportunistic Pathogens Obtained from Clinical Settings of Tamil Nadu for Developing Novel Alternative Therapeutics

Journal of Pure and Applied Microbiology, 2019
Opportunistic pathogens prevail in the hospital environment, and utensils are the root cause of severe nosocomial infection. These pathogens exhibit high antibiotic resistance due to constant exposure to drug therapy.
Rajendran Venkatasubramani, Thirumoorthy Viswanathan   +1 more
doaj   +1 more source