Results 21 to 30 of about 18,076 (146)

Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines [PDF]

Journal of the Serbian Chemical Society, 2016
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine.
Penjišević Jelena Z., Šukalović Vladimir V., Andrić Deana B., Roglić Goran M., Novaković Irena T., Šoškić Vukić, Kostić-Rajačić Slađana V.   +6 more
doaj   +1 more source

Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity

Journal of Advanced Research, 2018
Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated.
Suvankar Das, Cristiane J. da Silva, Marina de M. Silva, Maria Dayanne de A. Dantas, Ângelo de Fátima, Ana Lúcia T. Góis Ruiz, Cleiton M. da Silva, João Ernesto de Carvalho, Josué C.C. Santos, Isis M. Figueiredo, Edeildo F. da Silva-Júnior, Thiago M. de Aquino, João X. de Araújo-Júnior, Goutam Brahmachari, Luzia Valentina Modolo   +14 more
doaj   +1 more source

Synthesis of tetrafluorinated piperidines from nitrones via a visible-light-promoted annelation reaction

Beilstein Journal of Organic Chemistry, 2020
A method for the one-step construction of 3,3,4,4-tetrafluorinated piperidines from nitrones and readily accessible tetrafluorinated iodobromobutane is described.
Vyacheslav I. Supranovich, Igor A. Dmitriev, Alexander D. Dilman   +2 more
doaj   +1 more source

Dialkyl Carbonates in the Green Synthesis of Heterocycles

Frontiers in Chemistry, 2019
This review focuses on the use of dialkyl carbonates (DACs) as green reagents and solvents for the synthesis of several 5- and 6-membered heterocycles including: tetrahydrofuran and furan systems, pyrrolidines, indolines, isoindolines, 1,4-dioxanes ...
Pietro Tundo, Pietro Tundo, Manuele Musolino, Fabio Aricò   +3 more
doaj   +1 more source

Novel chemical entities inhibiting Mycobacterium tuberculosis growth identified by phenotypic high-throughput screening

Scientific Reports, 2022
We performed a high-throughput phenotypic whole cell screen of Mycobacterium tuberculosis against a diverse chemical library of approximately 100,000 compounds from the AbbVie corporate collection and identified 24 chemotypes with anti-tubercular ...
Anuradha Kumar, Somsundaram Chettiar, Brian S. Brown, Julie Early, Juliane Ollinger, Megan Files, Mai A. Bailey, Aaron Korkegian, Devon Dennison, Matthew McNeil, James Metz, Augustine Osuma, Michael Curtin, Aaron Kunzer, Gail Freiberg, Milan Bruncko, Dale Kempf, Tanya Parish   +17 more
doaj   +1 more source

Facile and Green Synthesis of Saturated Cyclic Amines

Molecules, 2017
Single-nitrogen containing saturated cyclic amines are an important part of both natural and synthetic bioactive compounds. A number of methodologies have been developed for the synthesis of aziridines, azetidines, pyrrolidines, piperidines, azepanes and
Arruje Hameed, Sadia Javed, Razia Noreen, Tayyaba Huma, Sarosh Iqbal, Huma Umbreen, Tahsin Gulzar, Tahir Farooq   +7 more
doaj   +1 more source

PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

Beilstein Journal of Organic Chemistry, 2011
PEG-embedded potassium tribromide ([K+PEG]Br3−) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester.
Sanny Verma, Suman L. Jain, Bir Sain
doaj   +1 more source

4-AMINOPIPERIDINAS Y ESPIRO-4-PIPERIDINAS: IMPORTANCIA FARMACOLÓGICA Y ESFUERZOS SINTÉTICOS

Universitas Scientiarum, 2007
The piperidine compounds from natural or synthetic origin are of a great scientific interest due to his widestatus of biological activities: analgesic, neuroleptic, neurotropic, etc.
L. Y. Vargas-Méndez, V. V. Kouznetsov
doaj  

Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones

Beilstein Journal of Organic Chemistry, 2010
The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the ...
Heloise Brice, Jonathan Clayden, Stuart D. Hamilton   +2 more
doaj   +1 more source

HMPA-Catalyzed Transfer Hydrogenation of 3-Carbonyl Pyridines and Other N-Heteroarenes with Trichlorosilane

Molecules, 2019
A method for the HMPA (hexamethylphosphoric triamide)-catalyzed metal-free transfer hydrogenation of pyridines has been developed. The functional group tolerance of the existing reaction conditions provides easy access to various piperidines with ester ...
Yun Fu, Jian Sun
doaj   +1 more source