Results 21 to 30 of about 24,641 (321)

Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts

Frontiers in Chemistry, 2019
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate ...
Alaa Zidan, Alaa Zidan, Abeer M. El-Naggar, Nour E. A. Abd El-Sattar, Ali Khalil Ali, Laurent El Kaïm   +5 more
doaj   +1 more source

Synthesis of Nitrogenated Heterocycles by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)haloimines [PDF]

, 2013
Highly optically enriched, protected, nitrogenated heterocycles with different ring sizes have been synthesized by a very efficient methodology consisting of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)haloimines followed by treatment ...
Ahn K., Almansa R., Almansa R., Alonso D. A., Andersson P. G., Bañón-Caballero A., Bosque I., Brak K., Breuer M., Callebaut G., Collados J. F., Corey E. J., Cutter A. C., Daly J. W., Darwish M., David Guijarro, Dema H. K., Denolf B., Denolf B., Dua R., Elliott R. L., Ellman J. A., Ellman J. A., Fattorusso E., Ferreira F., Gowda M., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guo T., Hansen K. B., Hart H., Hodgson D. M., Hodgson D. M., Holzer M., Kobayashi S., Kosciolowicz A., Lawrence A. K., Leemans E., Leemans E., Lin G.-Q., Lin N.-H., Louvel J., Louvel J., Mao J., Melchiorre P., Michael J. P., Miguel Yus, Noyori R., Nugent T. C., Nájera C., O’Hagan D., Pablo O., Palmer M. J., Patil M. P., Pinho P., Rao M. L. N., Reddy L. R., Reddy L. R., Reddy L. R., Robak M. T., Roth P., Royer J., Samano V., Senanayake C. H., Senter T. J., Siva S. R. N., Sun X., Tanner D., Vaultier M., Voituriez A., Wang C., Yu J., Óscar Pablo   +76 more
core   +2 more sources

1-[(3-Nitrophenyl)(piperidin-1-yl)methyl]piperidine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the crystal structure of the title compound, C17H25N3O2, one-dimensional chains are formed via intermolecular C—H...O hydrogen bonds along the a axis.
Zhe-Qin Wang, Yi Ma
openaire   +3 more sources

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine [PDF]

, 2008
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient
Adriaan J. Minnaard, Albrow, Alexakis, Alexakis, Anderson, Bach, Back, Beak, Beak, Beak, Beak, Beak, Beak, Beak, Ben L. Feringa, Bennett, Bennett, Berkheij, Bertini Gross, Brooks, Comins, Comins, Comins, Comins, Comins, Comins, Comins, Curtin, d'Augustin, Davis, Dieter, Dieter, Dieter, Dieter, Dieter, Eilitz, Frankel, Fraser, Gallagher, Garcia-Ruiz, Gardette, Gelas-Mialhe, Hoffmann, Houk, Kerrick, King, Leclercq, Liang, Maria Gabriella Pizzuti, Pilli, Pilli, Pineschi, Pàmies, Remuson, Slosse, Slosse, Still, Tawara, Vuagnoux-d'Augustin, Vuagnoux-d'Augustin, Watson, Whisler, Šebesta   +62 more
core   +1 more source

Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

Molecules, 2012
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl ...
Masashi Uchida, Mitsuko Miyamoto, Mika Kitsukawa, Masafumi Isogaya, Ryoji Hayashi, Kuniaki Kawamura, Takeshi Ishigaki, Yasuhiro Morita, Katsuhiko Iseki   +8 more
doaj   +1 more source

4-[4-(Piperidin-1-yl)piperidin-1-yl]benzonitrile [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(17)H(23)N(3), both piperidine rings adopt chair conformations. In the crystal packing, intermolecular C-H⋯N hydrogen bonds and C-H⋯π interactions are present.
Guo-bin Xu, Jian-you Shi, Li-juan Chen, You-fu Luo   +3 more
openaire   +3 more sources

Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents

Molecules, 2022
Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore, Jérome Lépeule, Tom Livinghouse   +2 more
doaj   +1 more source

Frontispiece: A Pd-Catalyzed Synthesis of Functionalized Piperidines [PDF]

, 2016
Pd Catalysis A readily available cyclic carbamate functions as a general precursor to a range of functionalized piperidine products using a new Pd-catalyzed annulation strategy.
Allen, B.D.W., Connolly, M.J., Harrity, J.P.A.   +2 more
core   +1 more source

Phenyl piperidine-1-carboxylate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
Dans le composé du titre, C(12)H(15)NO(2), l'angle dièdre entre le cycle benzénique et le plan basal du cycle pipéridine (qui est dans une conformation de chaise) est de 49,55 (8)°. Dans le cristal, les mol-écules sont liées par des liaisons hydrogène C-H 0 et des interactions C-H π très faibles.
Durre Shahwar, Muhammad Nawaz Tahir, Naeem Ahmad, Saif Ullah, Muhammad Akmal Khan   +4 more
openaire   +3 more sources

First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation [PDF]

, 2013
: A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C–H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to ...
Karl Kirchner, Maria C. Schwarz, Marko D. Mihovilovic, Michael Schnürch, Navid Dastbaravardeh   +4 more
core   +1 more source