Journal of Pure and Applied Microbiology, 2020 The pathogens attained through nosocomial infection exhibit a higher degree of antibiotic resistance due to constant exposure to drug therapy. There is a need to develop alternate therapeutics for treating these resistant pathogens.
Rajendran Venkatasubramani +1 more
doaj +1 more source
Methods for the synthesis of polyhydroxylated piperidines by diastereoselective dihydroxylation: Exploitation in the two-directional synthesis of aza-C-linked disaccharide derivatives [PDF]
, 2005 Background: Many polyhydroxylated piperidines are inhibitors of the oligosaccharide processing enzymes, glycosidases and glycosyltransferases. Aza-C-linked disaccharide mimetics are compounds in which saturated polyhydroxylated nitrogen and oxygen ...
Adam Nelson +8 more
core +3 more sources
Enantioselective Synthesis of Piperidines through the Formation of Chiral Mixed Phosphoric Acid Acetals: Experimental and Theoretical Studies [PDF]
, 2014 An enantioselective intramolecular chiral phosphoric acid‐catalyzed cyclization of unsaturated acetals has been utilized for the synthesis of functionalized chiral piperidines.
Nagorny, Pavel +3 more
core +3 more sources
Pot, atom and step economic (PASE) synthesis of highly functionalized piperidines: a five-component condensation [PDF]
, 2007 The diastereoselective pot, atom and step economic (PASE) synthesis of highly functionalized piperidines has been realized. The procedure simply involves mixing methyl acetoacetate, 2 equiv of aldehyde and 2 equiv of aniline together in the presence of ...
Clarke, Paul A. +2 more
core +1 more source
Molecules, 2019 GVL is a green solvent used in Fmoc-based solid-phase peptide synthesis. It is susceptible to ring opening in the presence of bases such as piperidines, which are used to remove the Fmoc protecting group.
Ashish Kumar +3 more
doaj +1 more source
Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines [PDF]
, 2012 The asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diaminocarboxylamide derivatives by highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycinamides across chiral alpha-chloro-N-p-toluenesulfinylaldimines was ...
Augustyns, Koen +5 more
core +3 more sources
A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro
Pharmaceuticals, 2022 There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–activity
Sonia De Castro +13 more
doaj +1 more source
Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts
Frontiers in Chemistry, 2019 We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate ...
Alaa Zidan +5 more
doaj +1 more source
Nature Communications, 2021 1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped.
Bo-Shuai Mu +4 more
doaj +1 more source
Frontispiece: A Pd-Catalyzed Synthesis of Functionalized Piperidines [PDF]
, 2016 Pd Catalysis A readily available cyclic carbamate functions as a general precursor to a range of functionalized piperidine products using a new Pd-catalyzed annulation strategy.
Allen, B.D.W. +2 more
core +1 more source