Results 31 to 40 of about 46,002 (241)

Crystal structure of 4-bromo-2-[(E)-N-(2,2,6,6-tetramethylpiperidin-4-yl)carboximidoyl]phenol dihydrate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title hydrate, C16H23BrN2O·2H2O, the organic molecule features a strong intramolecular O—H...N hydrogen bond. The piperidine ring, in addition, adopts a chair conformation with the exocyclic C—N bond in an equatorial orientation.
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Antar A. Abdelhamid, Mustafa R. Albayati   +4 more
doaj   +1 more source

Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides

Nature Communications, 2020
Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an ...
Josephine Eshon, Kate A. Nicastri, Steven C. Schmid, William T. Raskopf, Ilia A. Guzei, Israel Fernández, Jennifer M. Schomaker   +6 more
doaj   +1 more source

[Co(TPP)]‐Catalyzed Formation of Substituted Piperidines

Chemistry, 2019
Radical cyclization via cobalt(III)‐carbene radical intermediates is a powerful method for the synthesis of (hetero)cyclic structures. Building on the recently reported synthesis of five‐membered N‐heterocyclic pyrrolidines catalyzed by CoII porphyrins ...
Marianne Lankelma, Astrid M. Olivares, B. de Bruin   +2 more
semanticscholar   +1 more source

Ring Expansion of Vinylaziridines through the Strain-Release Pericyclic Reaction: Recent Developments and Applications

Molecules, 2013
Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
doaj   +1 more source

Highly functionalized piperidines: Free radical scavenging, anticancer activity, DNA interaction and correlation with biological activity

Journal of Advanced Research, 2018
Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated.
Suvankar Das, Cristiane J. da Silva, Marina de M. Silva, Maria Dayanne de A. Dantas, Ângelo de Fátima, Ana Lúcia T. Góis Ruiz, Cleiton M. da Silva, João Ernesto de Carvalho, Josué C.C. Santos, Isis M. Figueiredo, Edeildo F. da Silva-Júnior, Thiago M. de Aquino, João X. de Araújo-Júnior, Goutam Brahmachari, Luzia Valentina Modolo   +14 more
doaj   +1 more source

Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines [PDF]

Journal of the Serbian Chemical Society, 2016
A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine.
Penjišević Jelena Z., Šukalović Vladimir V., Andrić Deana B., Roglić Goran M., Novaković Irena T., Šoškić Vukić, Kostić-Rajačić Slađana V.   +6 more
doaj   +1 more source

A Modular and Diastereoselective 5+1 Cyclization Approach to N-(Hetero)Aryl Piperidines.

Journal of the American Chemical Society, 2019
A new general de novo synthesis of pharmaceutically important N-(hetero)aryl piperidines is reported. This protocol uses a robustly diastereoselective reductive amination/aza-Michael reaction se-quence to achieve rapid construction of complex ...
M. Larsen, Elisabeth T. Hennessy, Madeleine C. Deem, Yu-hong Lam, J. Saurí, Aaron C. Sather   +5 more
semanticscholar   +1 more source

Synthesis of tetrafluorinated piperidines from nitrones via a visible-light-promoted annelation reaction

Beilstein Journal of Organic Chemistry, 2020
A method for the one-step construction of 3,3,4,4-tetrafluorinated piperidines from nitrones and readily accessible tetrafluorinated iodobromobutane is described.
Vyacheslav I. Supranovich, Igor A. Dmitriev, Alexander D. Dilman   +2 more
doaj   +1 more source

Regio- and Stereoselective Palladium-Catalyzed C(sp3)-H Arylation of Pyrrolidines and Piperidines with C(3) Directing Groups.

Organic Letters, 2018
The selective synthesis of cis-3,4-disubstituted pyrrolidines and piperidines is achieved by a Pd-catalyzed C-H arylation with excellent regio- and stereoselectivity using an aminoquinoline auxiliary at C(3). The arylation conditions are silver free, use
Daniele Antermite, Dominic P. Affron, J. Bull   +2 more
semanticscholar   +1 more source

Dialkyl Carbonates in the Green Synthesis of Heterocycles

Frontiers in Chemistry, 2019
This review focuses on the use of dialkyl carbonates (DACs) as green reagents and solvents for the synthesis of several 5- and 6-membered heterocycles including: tetrahydrofuran and furan systems, pyrrolidines, indolines, isoindolines, 1,4-dioxanes ...
Pietro Tundo, Pietro Tundo, Manuele Musolino, Fabio Aricò   +3 more
doaj   +1 more source