Results 31 to 40 of about 40,506 (345)
Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents
Molecules, 2022 Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore +2 more
doaj +1 more source
Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation.
Chem, 2019 Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffler-Freytag (HLF)
Zuxiao Zhang, Xin Zhang, David A. Nagib
semanticscholar +1 more source
Journal of Pure and Applied Microbiology, 2019 Opportunistic pathogens prevail in the hospital environment, and utensils are the root cause of severe nosocomial infection. These pathogens exhibit high antibiotic resistance due to constant exposure to drug therapy.
Rajendran Venkatasubramani +1 more
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title hydrate, C16H23BrN2O·2H2O, the organic molecule features a strong intramolecular O—H...N hydrogen bond. The piperidine ring, in addition, adopts a chair conformation with the exocyclic C—N bond in an equatorial orientation.
Joel T. Mague +4 more
doaj +1 more source
Nature Communications, 2020 Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an ...
Josephine Eshon +6 more
doaj +1 more source
Structures of piperazine, piperidine and morpholine [PDF]
Acta Crystallographica Section B Structural Science, 2004 The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so that the molecules interleave. In morpholine there are in addition weak CH...O interactions.
Parkin, A, Oswald, I D H, Parsons, S
openaire +5 more sources
Molecules, 2013 Recent syntheses of azetidines, pyrrolidines, piperidines and azepines through cycloaddition or sigmatropic rearrangements of vinylaziridines are described. Applications to natural product synthesis and mechanistic investigations are also summarized.
Yu Mi Heo, Seung-Mann Paek
doaj +1 more source
Journal of Advanced Research, 2018 Twenty-five piperidines were studied as potential radical scavengers and antitumor agents. Quantitative interaction of compounds with ctDNA using spectroscopic techniques was also evaluated.
Suvankar Das +14 more
doaj +1 more source
Synthesis, biological evaluation and docking analysis of substituted piperidines and (2-methoxyphenyl)piperazines [PDF]
Journal of the Serbian Chemical Society, 2016 A series of sixteen novel substituted piperidines and (2-methoxyphenyl)piperazines were synthesized, starting from the key intermediates 1-(2-methoxyphenyl)-4-(piperidin-4-yl)piperazine and 1-(2-methoxyphenyl)-4-(piperidin-4-ylmethyl)piperazine.
Penjišević Jelena Z. +6 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2020 A method for the one-step construction of 3,3,4,4-tetrafluorinated piperidines from nitrones and readily accessible tetrafluorinated iodobromobutane is described.
Vyacheslav I. Supranovich +2 more
doaj +1 more source