Results 31 to 40 of about 24,519 (327)

Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

Molecules, 2012
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl ...
Masashi Uchida, Mitsuko Miyamoto, Mika Kitsukawa, Masafumi Isogaya, Ryoji Hayashi, Kuniaki Kawamura, Takeshi Ishigaki, Yasuhiro Morita, Katsuhiko Iseki   +8 more
doaj   +1 more source

First selective direct mono-arylation of piperidines using ruthenium-catalyzed C–H activation [PDF]

, 2013
: A Ru-catalyzed mono-arylation in α-position of saturated cyclic amines is reported employing a C–H activation protocol. Substitution of the pyridine directing group with a bulky group, e.g., trifluoromethyl in the 3-position, proved to be crucial to ...
Karl Kirchner, Maria C. Schwarz, Marko D. Mihovilovic, Michael Schnürch, Navid Dastbaravardeh   +4 more
core   +1 more source

Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents

Molecules, 2022
Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore, Jérome Lépeule, Tom Livinghouse   +2 more
doaj   +1 more source

Synthesis of Nitrogenated Heterocycles by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)haloimines [PDF]

, 2013
Highly optically enriched, protected, nitrogenated heterocycles with different ring sizes have been synthesized by a very efficient methodology consisting of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)haloimines followed by treatment ...
Ahn K., Almansa R., Almansa R., Alonso D. A., Andersson P. G., Bañón-Caballero A., Bosque I., Brak K., Breuer M., Callebaut G., Collados J. F., Corey E. J., Cutter A. C., Daly J. W., Darwish M., David Guijarro, Dema H. K., Denolf B., Denolf B., Dua R., Elliott R. L., Ellman J. A., Ellman J. A., Fattorusso E., Ferreira F., Gowda M., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guo T., Hansen K. B., Hart H., Hodgson D. M., Hodgson D. M., Holzer M., Kobayashi S., Kosciolowicz A., Lawrence A. K., Leemans E., Leemans E., Lin G.-Q., Lin N.-H., Louvel J., Louvel J., Mao J., Melchiorre P., Michael J. P., Miguel Yus, Noyori R., Nugent T. C., Nájera C., O’Hagan D., Pablo O., Palmer M. J., Patil M. P., Pinho P., Rao M. L. N., Reddy L. R., Reddy L. R., Reddy L. R., Robak M. T., Roth P., Royer J., Samano V., Senanayake C. H., Senter T. J., Siva S. R. N., Sun X., Tanner D., Vaultier M., Voituriez A., Wang C., Yu J., Óscar Pablo   +76 more
core   +2 more sources

Catalytic asymmetric synthesis of the alkaloid (+)-myrtine [PDF]

, 2008
A new protocol for the asymmetric synthesis of trans-2,6-disubstituted-4-piperidones has been developed using a catalytic enantioselective conjugate addition reaction in combination with a diastereoselective lithiation–substitution sequence; an efficient
Adriaan J. Minnaard, Albrow, Alexakis, Alexakis, Anderson, Bach, Back, Beak, Beak, Beak, Beak, Beak, Beak, Beak, Ben L. Feringa, Bennett, Bennett, Berkheij, Bertini Gross, Brooks, Comins, Comins, Comins, Comins, Comins, Comins, Comins, Curtin, d'Augustin, Davis, Dieter, Dieter, Dieter, Dieter, Dieter, Eilitz, Frankel, Fraser, Gallagher, Garcia-Ruiz, Gardette, Gelas-Mialhe, Hoffmann, Houk, Kerrick, King, Leclercq, Liang, Maria Gabriella Pizzuti, Pilli, Pilli, Pineschi, Pàmies, Remuson, Slosse, Slosse, Still, Tawara, Vuagnoux-d'Augustin, Vuagnoux-d'Augustin, Watson, Whisler, Šebesta   +62 more
core   +1 more source

Study on Multi Drug Resistant Opportunistic Pathogens Obtained from Clinical Settings of Tamil Nadu for Developing Novel Alternative Therapeutics

Journal of Pure and Applied Microbiology, 2019
Opportunistic pathogens prevail in the hospital environment, and utensils are the root cause of severe nosocomial infection. These pathogens exhibit high antibiotic resistance due to constant exposure to drug therapy.
Rajendran Venkatasubramani, Thirumoorthy Viswanathan   +1 more
doaj   +1 more source

1-[(3-Nitrophenyl)(piperidin-1-yl)methyl]piperidine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the crystal structure of the title compound, C17H25N3O2, one-dimensional chains are formed via intermolecular C—H...O hydrogen bonds along the a axis.
Zhe-Qin Wang, Yi Ma
openaire   +3 more sources

Intermolecular [3+3] ring expansion of aziridines to dehydropiperi-dines through the intermediacy of aziridinium ylides

Nature Communications, 2020
Traditional synthesis of stereodefined piperidines requires selective installation of functional groups that can lower efficiency and modularity. Here, the authors assemble stereochemically complex and highly substituted dehydropiperidines via an ...
Josephine Eshon, Kate A. Nicastri, Steven C. Schmid, William T. Raskopf, Ilia A. Guzei, Israel Fernández, Jennifer M. Schomaker   +6 more
doaj   +1 more source

Crystal structure of 4-bromo-2-[(E)-N-(2,2,6,6-tetramethylpiperidin-4-yl)carboximidoyl]phenol dihydrate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title hydrate, C16H23BrN2O·2H2O, the organic molecule features a strong intramolecular O—H...N hydrogen bond. The piperidine ring, in addition, adopts a chair conformation with the exocyclic C—N bond in an equatorial orientation.
Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Antar A. Abdelhamid, Mustafa R. Albayati   +4 more
doaj   +1 more source

Synthesis and kinetic resolution of N-Boc-2-arylpiperidines [PDF]

, 2014
The chiral base n-BuLi/(-)-sparteine or n-BuLi/(+)-sparteine surrogate promotes kinetic resolution of N-Boc-2-arylpiperidines by asymmetric deprotonation. The enantioenriched starting material was recovered with yields 39-48% and ers up to 97:3.
Bailey, Barker, Becker, Beng, Beng, Binanzer, Coldham, Coldham, Cui, Daniele Leonori, Edward J. Cochrane, Faibish, Granander, Hardy, Harrison, Hesp, Horton, Hsieh, Hsieh, Iain Coldham, Kagan, Kessar, Krasnov, Kreituss, Li, Lorraine A. Hassall, Millet, O'Brien, Pellissier, Penning, Rutherford, Seel, Sheikh, Stead, Strohmann, Vo, Xiao, Xiao, Xiao, Zuo   +39 more
core   +1 more source