Results 31 to 40 of about 23,915 (334)

Asymmetric synthesis of γ-chloro-α,β-diamino- and β,γ-aziridino-α-aminoacylpyrrolidines and -piperidines via stereoselective Mannich-type additions of N-(diphenylmethylene)glycinamides across α-chloro-N-sulfinylimines [PDF]

, 2012
The asymmetric synthesis of new chiral gamma-chloro-alpha,beta-diaminocarboxylamide derivatives by highly diastereoselective Mannich-type reactions of N-(diphenylmethylene) glycinamides across chiral alpha-chloro-N-p-toluenesulfinylaldimines was ...
Augustyns, Koen, Callebaut, Gert, De Kimpe, Norbert, Mangelinckx, Sven, Tornroos, Karl W, Van der Veken, Pieter   +5 more
core   +3 more sources

Raising the Diversity of Ugi Reactions Through Selective Alkylations and Allylations of Ugi Adducts

Frontiers in Chemistry, 2019
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acetate ...
Alaa Zidan, Alaa Zidan, Abeer M. El-Naggar, Nour E. A. Abd El-Sattar, Ali Khalil Ali, Laurent El Kaïm   +5 more
doaj   +1 more source

Modular synthesis of chiral 1,2-dihydropyridines via Mannich/Wittig/cycloisomerization sequence that internally reuses waste

Nature Communications, 2021
1,2-Dihydropyridines are valuable precursors for the synthesis of biologically relevant piperidines and pyridines, but the methods for their synthesis are underdeveloped.
Bo-Shuai Mu, Xiao-Yuan Cui, Xing-Ping Zeng, Jin-Sheng Yu, Jian Zhou   +4 more
doaj   +1 more source

A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

Pharmaceuticals, 2022
There is a clear need for novel antiviral concepts to control SARS-CoV-2 infection. Based on the promising anti-coronavirus activity observed for a class of 1,4,4-trisubstituted piperidines, we here conducted a detailed analysis of the structure–activity
Sonia De Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin Van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens   +13 more
doaj   +1 more source

An Efficient Synthesis of Aldohexose-Derived Piperidine Nitrones: Precursors of Piperidine Iminosugars [PDF]

Molecules, 2013
D-Glucopyranose-derived and L-idopyranose-derived piperidine nitrones were synthesized in good overall yields through six-step reaction sequence starting from readily available 2,3,4,6-tetra-O-benzyl-D-glucopyranose. The method is efficient and could be general for the synthesis of aldohexose-derived piperidine nitrones which are precursors of ...
Jian-She Zhu, Chu-Yi Yu, Hui Zhao, Wen-Bo Zhao, Yue-Mei Jia   +4 more
openaire   +4 more sources

Synthesis of Novel IP Agonists via N-Aminoethyl Cyclic Amines Prepared by Decarboxylative Ring-Opening Reactions

Molecules, 2012
An efficient synthesis of a highly potent and selective IP (PGI2 receptor) agonist that is not structurally analogous to PGI2 is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl ...
Masashi Uchida, Mitsuko Miyamoto, Mika Kitsukawa, Masafumi Isogaya, Ryoji Hayashi, Kuniaki Kawamura, Takeshi Ishigaki, Yasuhiro Morita, Katsuhiko Iseki   +8 more
doaj   +1 more source

Piperidine-1-carboximidamide [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
In the title compound, C(6)H(13)N(3), the C=N and C-N bond lengths in the CN(3) unit are 1.3090 (17), and 1.3640 (17) (C-NH(2)) and 1.3773 (16) Å, indicating double- and single-bond character, respectively. The N-C-N angles are 116.82 (12), 119.08 (11) and 124.09 (11)°, showing a deviation of the CN(3) plane from an ideal trigonal-planar geometry.
openaire   +3 more sources

Frontispiece: A Pd-Catalyzed Synthesis of Functionalized Piperidines [PDF]

, 2016
Pd Catalysis A readily available cyclic carbamate functions as a general precursor to a range of functionalized piperidine products using a new Pd-catalyzed annulation strategy.
Allen, B.D.W., Connolly, M.J., Harrity, J.P.A.   +2 more
core   +1 more source

Synthesis of Nitrogenated Heterocycles by Asymmetric Transfer Hydrogenation of N-(tert-Butylsulfinyl)haloimines [PDF]

, 2013
Highly optically enriched, protected, nitrogenated heterocycles with different ring sizes have been synthesized by a very efficient methodology consisting of the asymmetric transfer hydrogenation of N-(tert-butylsulfinyl)haloimines followed by treatment ...
Ahn K., Almansa R., Almansa R., Alonso D. A., Andersson P. G., Bañón-Caballero A., Bosque I., Brak K., Breuer M., Callebaut G., Collados J. F., Corey E. J., Cutter A. C., Daly J. W., Darwish M., David Guijarro, Dema H. K., Denolf B., Denolf B., Dua R., Elliott R. L., Ellman J. A., Ellman J. A., Fattorusso E., Ferreira F., Gowda M., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guijarro D., Guo T., Hansen K. B., Hart H., Hodgson D. M., Hodgson D. M., Holzer M., Kobayashi S., Kosciolowicz A., Lawrence A. K., Leemans E., Leemans E., Lin G.-Q., Lin N.-H., Louvel J., Louvel J., Mao J., Melchiorre P., Michael J. P., Miguel Yus, Noyori R., Nugent T. C., Nájera C., O’Hagan D., Pablo O., Palmer M. J., Patil M. P., Pinho P., Rao M. L. N., Reddy L. R., Reddy L. R., Reddy L. R., Robak M. T., Roth P., Royer J., Samano V., Senanayake C. H., Senter T. J., Siva S. R. N., Sun X., Tanner D., Vaultier M., Voituriez A., Wang C., Yu J., Óscar Pablo   +76 more
core   +2 more sources

Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents

Molecules, 2022
Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration.
Christian Frabitore, Jérome Lépeule, Tom Livinghouse   +2 more
doaj   +1 more source