Results 71 to 80 of about 23,915 (334)

5,7‐Membered Cyclometallated Gold(III) Complexes with Pyridine‐Phenyl‐Oxazoline N^C^N Ligands as Catalysts for Organic Transformation Reactions Under Silver‐Free Conditions

Advanced Synthesis &Catalysis, EarlyView.
A series of 5,7‐membered cyclometallated gold(III) complexes with N^C^N tridentate ligands are prepared via transmetalation of pyridine‐phenyl‐oxazoline ligand‐containing organomercury compounds with potassium gold(III) chloride (KAuCl4) for catalysis.
Yosephine Tania Limanto, Karen Ka‐Yan Kung, Aries Kwok‐Heung Chan, Nathanael Chun‐Him Lai, Man‐Kin Wong   +4 more
wiley   +1 more source

Experimental study of local anesthetic and antiarrhythmic activities of fluorinated ethynylpiperidine derivatives [PDF]

Brazilian Journal of Medical and Biological Research
The chemical structure of piperidine has a unique ability to combine with other molecular fragments. This fact makes it possible to actively use it as an effective basis for the creation of new drug-like substances.
E.M. Satbayeva, S.S. Zhumakova, M.D. Khaiitova, U.S. Kemelbekov, F.M. Tursunkhodzhaeva, A.A. Azamatov, Sh.N. Tursymbek, V.Kh. Sabirov, T.S. Nurgozhin, V.K. Yu, T.M. Seilkhanov   +10 more
doaj   +1 more source

Synthesis and Evaluation of Novel Iminosugars Prepared from Natural Amino Acids

Molecules, 2021
Cyclopropanated iminosugars have a locked conformation that may enhance the inhibitory activity and selectivity against different glycosidases. We show the synthesis of new cyclopropane-containing piperidines bearing five stereogenic centers from natural
Alejandro Puet, Gema Domínguez, Francisco Javier Cañada, Javier Pérez-Castells   +3 more
doaj   +1 more source

The preparative synthetic approach to 4-(trifluoromethoxy)piperidine and 4-(trifluoromethoxymethyl)piperidine

Journal of Organic and Pharmaceutical Chemistry, 2021
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry.Results and discussion. 4-(Trifluoromethoxy)piperidine (8.4 g) and 4-(trifluoromethoxymethyl)piperidine (12.9 g) were synthesized in 5 ...
Ivan G. Logvinenko, Violetta G. Dolovanyuk, Ivan S. Kondratov   +2 more
openaire   +4 more sources

Azabicyclo[1.1.0]butyl‐Substituted Sulfonimidoyl Fluoride: Electrophilic Hub Bridging Late‐Stage Azetidine Incorporation with Sufex Chemistry

Advanced Synthesis &Catalysis, EarlyView.
GA: Strained small motifs and SuFEx hubs are of increasing importance in drug discovery to enable efficient late‐stage functionalization. Here, the synthesis of bench‐stable azabicyclo[1.1.0]butyl‐substituted sulfonimidoyl fluoride as an electrophilic hub with dual activation mode is reported.
Defne Serbetci, Philipp Natho, Ernesto Mesto, Emanuela Schingaro, Marco Colella, Renzo Luisi   +5 more
wiley   +1 more source

Ultrasound accelerated one-​pot five component reaction: a facile access to functionalized piperidines [PDF]

, 2016
A one-​pot five-​component coupling of aryl aldehydes, aryl amines and β-​keto ester affords functionalized piperidines I [R1 = C6H5, 4-​FC6H4, 3,​4,​5-​(OCH3)​3C6H2; R2 = C6H5, 4-​CH3C6H4; R3 = CH3, CH2CH3] under sonication (35 kHz) is developed ...
Pasha, M.A., Sudha, S.
core  

A Most Unusual Zeolite Templating: Cage to Cage Connection of One Guest Molecule [PDF]

, 2010
An unusual case of a diquaternary ammonium dication, with large bulky end groups built from the tropane moiety and connected by a C4 methylene chain, is found to reside in zeolite SSZ-35 (STF).
Burton, Allen W., Hwang, Son-Jong, Jackowski, Anna, Kim, Chul, Olmstead, Marilyn M., Teat, Simon J., Zones, S. I.   +6 more
core   +1 more source

Synthesis of Amidines Via P(III)/P(V)O Redox Catalyzed In Situ Formation of Imidoyl Chlorides From Amides

Advanced Synthesis &Catalysis, EarlyView.
A series of amidines are prepared via PIII/PVO redox catalyzed in situ formation of imidoyl chlorides from amides. The desired products are obtained in good to excellent yields. Moreover, the protocol is applied to the synthesis of Erlotinib. Amidines are a ubiquitous class of bioactive compounds found in a wide variety of natural products; thus ...
Viktorija Medvarić, Jan Paradies, Thomas Werner   +2 more
wiley   +1 more source

Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles

Beilstein Journal of Organic Chemistry, 2012
A versatile nitro-Mannich/lactamisation cascade for the direct stereoselective synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles has been developed. A highly enantioenriched substituted 5-nitropiperidin-2-one was synthesised
Pavol Jakubec, Dane M. Cockfield, Madeleine Helliwell, James Raftery, Darren J. Dixon   +4 more
doaj   +1 more source

Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial

BMC Anesthesiology, 2020
Background Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination.
Li Jia, Meng Xie, Jing Zhang, Jingyu Guo, Tong Tong, Yuying Xing   +5 more
doaj   +1 more source