Results 71 to 80 of about 24,641 (321)

Sodium piperidine-1-carbodithioate dihydrate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2011
The asymmetric unit of the title compound, Na(+)·C(6)H(10)NS(2) (-)·2H(2)O, is composed of a sodium cation, a piperidine-dithio-carbamate anion which exhibits positional disorder, and two lattice water mol-ecules. The atoms of the piperidine ring are divided over two sites with occupancy factors of 0.554 (6) and 0.446 (6).
Ana C. Mafud, Maria Teresa P. Gambardella   +1 more
openaire   +3 more sources

Acid‐ and Nucleophile‐Gated Photoisomerization of Phosphaindirubin

Angewandte Chemie, EarlyView.
Triply gated isomerization: In polar solvents, a phosphorus‐containing indirubin photoswitch undergoes visible‐light‐driven Z→E isomerization only when protonated, and reverts thermally via nucleophile‐catalyzed back‐isomerization. This three‐way control by light, acid, and nucleophile enables reversible photoisomerization.
Jacob Jan van der Wal, Jorn D. Steen, Ann‐Kathrin Rückert, Roman Yu. Peshkov, Michiel F. Hilbers, P. Tim Prins, Wybren Jan Buma, Andreas Orthaber, Stefano Crespi   +8 more
wiley   +2 more sources

Efficacy of different dose of dexmedetomidine combined with remifentanil in colonoscopy: a randomized controlled trial

BMC Anesthesiology, 2020
Background Dexmedetomidine has advantages during colonoscopy as it allows the patient to cooperate during the procedure. Few studies examined the dexmedetomidine-remifentanil combination.
Li Jia, Meng Xie, Jing Zhang, Jingyu Guo, Tong Tong, Yuying Xing   +5 more
doaj   +1 more source

Ultrasound accelerated one-​pot five component reaction: a facile access to functionalized piperidines [PDF]

, 2016
A one-​pot five-​component coupling of aryl aldehydes, aryl amines and β-​keto ester affords functionalized piperidines I [R1 = C6H5, 4-​FC6H4, 3,​4,​5-​(OCH3)​3C6H2; R2 = C6H5, 4-​CH3C6H4; R3 = CH3, CH2CH3] under sonication (35 kHz) is developed ...
Pasha, M.A., Sudha, S.
core  

Base-catalyzed reactions of environmentally relevant N-chloro-piperidines. A quantum-chemical study [PDF]

, 2011
Electronic structure methods have been applied to calculate the gas and aqueous phase reaction energies for base-induced rearrangements of N-chloropiperidine, N-chloro-3-(hydroxymethyl)piperidine, and N-chloro-4-4-fluorophenyl)-3-(hydroxymethyl ...
Sakic, Davor, Vrcek, Valerije, Zipse, Hendrik   +2 more
core   +1 more source

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, EarlyView.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +2 more sources

Stereoselective, nitro-Mannich/lactamisation cascades for the direct synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles

Beilstein Journal of Organic Chemistry, 2012
A versatile nitro-Mannich/lactamisation cascade for the direct stereoselective synthesis of heavily decorated 5-nitropiperidin-2-ones and related heterocycles has been developed. A highly enantioenriched substituted 5-nitropiperidin-2-one was synthesised
Pavol Jakubec, Dane M. Cockfield, Madeleine Helliwell, James Raftery, Darren J. Dixon   +4 more
doaj   +1 more source

Experimental study of local anesthetic and antiarrhythmic activities of fluorinated ethynylpiperidine derivatives [PDF]

Brazilian Journal of Medical and Biological Research
The chemical structure of piperidine has a unique ability to combine with other molecular fragments. This fact makes it possible to actively use it as an effective basis for the creation of new drug-like substances.
E.M. Satbayeva, S.S. Zhumakova, M.D. Khaiitova, U.S. Kemelbekov, F.M. Tursunkhodzhaeva, A.A. Azamatov, Sh.N. Tursymbek, V.Kh. Sabirov, T.S. Nurgozhin, V.K. Yu, T.M. Seilkhanov   +10 more
doaj   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source