Results 81 to 90 of about 47,089 (385)

Silacyclohexanes, Sila(hetero)cyclohexanes and Related Compounds: Structure and Conformational Analysis

Molecules, 2020
Conformational analysis of Si-mono- and Si,Si-disubstituted silacyclohexanes as well as their analogues with a heteroatom(s) in the ring is reviewed with the focus on the recent results.
Bagrat A. Shainyan
doaj   +1 more source

Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine to alkyl acrylates : application towards the synthesis of 2-(methoxycarbonyl)indolizidine [PDF]

, 2009
Conjugate addition of 2-(bromomethyl)- and 2-(2-bromoethyl)piperidine hydrobromide to methyl and ethyl acrylate in the presence of triethylamine afforded the corresponding 3-[2-(bromomethyl)piperidin-1-yl]propanoates and 3-[2-(2-bromoethyl)piperidin-1-yl]
Abbaspour Tehrani, Kourosch, Buyck, Christophe, D'hooghe, Matthias, De Kimpe, Norbert   +3 more
core   +2 more sources

The preparative synthetic approach to 4-(trifluoromethoxy)piperidine and 4-(trifluoromethoxymethyl)piperidine

Journal of Organic and Pharmaceutical Chemistry, 2021
Aim. To develop a convenient synthetic approach for the preparation of multigram amounts of 4-(trifluoromethoxy)-piperidine and 4-(trifluoromethoxymethyl)piperidine – promising building blocks for medicinal chemistry.Results and discussion. 4-(Trifluoromethoxy)piperidine (8.4 g) and 4-(trifluoromethoxymethyl)piperidine (12.9 g) were synthesized in 5 ...
Ivan G. Logvinenko, Violetta G. Dolovanyuk, Ivan S. Kondratov   +2 more
openaire   +4 more sources

Gold(I)-Catalyzed Enantioselective Annulations between Allenes and Alkene-Tethered Oxime Ethers: A Straight Entry to Highly Substituted Piperidines and aza-Bridged Medium-Sized Carbocycles.

Journal of the American Chemical Society, 2018
Piperidine scaffolds are present in a wide range of bioactive natural products and are therefore considered as highly valuable, privileged synthetic targets.
David C Marcote, Iván Varela, J. Fernández-Casado, J. Mascareñas, F. López   +4 more
semanticscholar   +1 more source

Norbornene Homopolymerization Limits Cell Spreading in Thiol–Ene Photoclick Hydrogels

Advanced Healthcare Materials, EarlyView.
Thiol–norbornene click reactions are often used in the development of cell‐permissive 3D hydrogels. However, ene–ene crosslinks in other thiol–ene systems are known to limit permissivity. This study demonstrates the negative effects of norbornene homopolymerization on 3D cell spreading and circumvents the issue by modulating polymer degree of ...
James L. Gentry, Steven R. Caliari
wiley   +1 more source

4-AMINOPIPERIDINAS Y ESPIRO-4-PIPERIDINAS: IMPORTANCIA FARMACOLÓGICA Y ESFUERZOS SINTÉTICOS

Universitas Scientiarum, 2007
The piperidine compounds from natural or synthetic origin are of a great scientific interest due to his widestatus of biological activities: analgesic, neuroleptic, neurotropic, etc.
L. Y. Vargas-Méndez, V. V. Kouznetsov
doaj  

Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones

Beilstein Journal of Organic Chemistry, 2010
The silyl enol ether derivatives of ketones or esters tethered by a hydrocarbon or ether linkage to the 3-position of a pyridine ring undergo dearomatising nucleophilic attack on the ring once it is activated (as an acylpyridinium species) by the ...
Heloise Brice, Jonathan Clayden, Stuart D. Hamilton   +2 more
doaj   +1 more source

[Cp*Ru]-catalyzed selective coupling/hydrogenation

, 2015
International ...
Achard, Mathieu, Bruneau, Christian, Dérien, Sylvie, Jiang, F., Kabouche, Z., Labed, A., Labed, I., Sun, Yang   +7 more
core   +2 more sources

Orally Active MMP-1 Sparing α-tetrahydropyranyl and α-piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease [PDF]

, 2010
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP’s-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in the ...
Barta, Thomas E., Becker, Daniel P, Bedell, Louis J., Boehm, Terri L.   +3 more
core   +1 more source

Pyrrolidines and piperidines bearing chiral tertiary alcohols by nickel-catalyzed enantioselective reductive cyclization of N-alkynones

Communications Chemistry, 2018
Pyrrolidines and piperidines are important building blocks in organic synthesis. Numerous methods exist for constructing substituted pyrrolidines and piperidines.
Guodu Liu, Wenzhen Fu, Xingye Mu, Ting-Ting Wu, M. Nie, Kaidi Li, Xiaodong Xu, Wenjun Tang   +7 more
semanticscholar   +1 more source