Results 61 to 70 of about 2,792 (196)

In vitro release of two anti-muscarinic drugs from soft contact lenses

Clinical Ophthalmology, 2017
Alex Hui,1 Magdalena Bajgrowicz-Cieslak,2 Chau-Minh Phan,3 Lyndon Jones3 1School of Optometry and Vision Science, UNSW Sydney, Sydney, NSW, Australia; 2Department of Mechanics, Material Science and Engineering, Wroclaw University of Technology, Wroclaw,
Hui A, Bajgrowicz-Cieslak M, Phan CM, Jones L   +3 more
doaj  

Activation of M1 mAChRs by lesatropane rescues glutamate neurotoxicity in PC12 cells via PKC-mediated phosphorylation of ERK1/2

Biomolecules & Biomedicine, 2013
Lesatropane, a synthesized chiral tropane (3S, 6S-isomer of satropane), is a novel muscarinic agonist, and is being under preclinical development in China for the treatment of primary glaucoma.
Ke Ma, Zhi-Hui Yang, Li-Min Yang, Hong-Zhuan Chen, Yang Lu   +4 more
doaj   +1 more source

Muscarinic depolarization of layer II neurons of the parasubiculum. [PDF]

PLoS ONE, 2013
The parasubiculum (PaS) is a component of the hippocampal formation that sends its major output to layer II of the entorhinal cortex. The PaS receives strong cholinergic innervation from the basal forebrain that is likely to modulate neuronal ...
Stephen D Glasgow, C Andrew Chapman
doaj   +1 more source

Normal and Pathological Tau Uptake Mediated by M1/M3 Muscarinic Receptors Promotes Opposite Neuronal Changes

Frontiers in Cellular Neuroscience, 2019
The microtubule associated protein tau is mainly found in the cell’s cytosol but recently it was also shown in the extracellular space. In neurodegenerative diseases, like Alzheimer’s disease (AD), pathological tau spreads from neuron to neuron enhancing
Viktoriya Morozova, Viktoriya Morozova, Leah S. Cohen, Ali El-Hadi Makki, Alison Shur, Alison Shur, Guillermo Pilar, Abdeslem El Idrissi, Abdeslem El Idrissi, Alejandra D. Alonso, Alejandra D. Alonso   +10 more
doaj   +1 more source

Effects of cholecystokinin-octapeptide and cerulein on ovine digestive motility under cholinergic blockade

European Journal of Biological Research, 2017
In sheep, contribution of cholinergic system to the control of gastrointestinal motility by cholecystokinin is unknown. Accordingly, in six non-fasted rams chronic experiments were conducted and the myoelectrical activity of abomasal antrum, duodenum and
Krzysztof W. Romański
doaj  

Autoantibodies against Submandibular Gland Muscarinic Cholinoceptor Subtypes in Primary Sjögren Syndrome

European Journal of Inflammation, 2005
Sjögren Syndrome (SS) is a chronic autoimmune disease characterized by parasympathetic exocrine gland dysfunction. Here, the involvement of submandibular gland muscarinic acetylcholine receptor (mAChR) M 4 subtype is proposed as an IgG target together ...
S. Reina, L. Sterin-Borda, B. Orman, E. Borda   +3 more
doaj   +1 more source

The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding

Brain Sciences, 2020
Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric disorders. The basis of these effects is not fully understood, but may involve altered cholinergic neurotransmission. This study
Sarah S. Ch’ng, Adam J. Walker, Madeleine McCarthy, Thien-Kim Le, Natalie Thomas, Andrew Gibbons, Madhara Udawela, Snezana Kusljic, Brian Dean, Andrea Gogos   +9 more
doaj   +1 more source

The Lower Urinary Tract Science Group Abstracts—ICI‐RS 2024

Neurourology and Urodynamics, Volume 44, Issue 3, Page 691-697, March 2025.
Christopher H. Fry, Andrew Gammie, Bahareh Vahabi, Faezeh A. Hassani, Karen D. McCloskey, Mathijs M. de Rijk, Pradeep Tyagi, Hikaru Hashitani, Michael Winder, Patrik Aronsson, Basu Chakrabarty   +10 more
wiley   +1 more source

Behavioral effects of Bj-PRO-7a, a proline-rich oligopeptide from Bothrops jararaca venom [PDF]

Brazilian Journal of Medical and Biological Research
The heptapeptide Bj-PRO-7a, isolated and identified from Bothrops jararaca (Bj) venom, produces antihypertensive and other cardiovascular effects that are independent on angiotensin converting enzyme inhibition, possibly relying on cholinergic muscarinic
L.C. Turones, K.R. da Cruz, G. Camargo-Silva, L.L. Reis-Silva, D. Graziani, P.M. Ferreira, P.M. Galdino, G.R. Pedrino, R. Santos, E.A. Costa, D. Ianzer, C.H. Xavier   +11 more
doaj   +2 more sources

Effect of Mutated Cu, Zn Superoxide Dismutase (SOD1G93A) on Modulation of Transductional Pathway Mediated by M1 Muscarinic Receptor in SK-N-BE and NSC-34 Cells

Frontiers in Physiology, 2018
The constitutive secretion of antioxidant Cu-Zn Superoxide dismutase (SOD1) has been widely demonstrated in many cellular lines. In addition, we showed that as well as the basal SOD1 secretion, this enzyme is also exported through depolarization of ...
Simona Damiano, Anna Sasso, Roberta Accetta, Marcellino Monda, Bruno De Luca, Luigi Michele Pavone, Anna Belfiore, Mariarosaria Santillo, Paolo Mondola   +8 more
doaj   +1 more source