Results 91 to 100 of about 1,197 (187)

Pitolisant 40 mg for excessive daytime sleepiness in obstructive sleep apnea patients treated or not by CPAP: Randomised phase 3 study

Journal of Sleep Research
Obstructive sleep apnea (OSA) syndrome commonly leads to excessive daytime sleepiness (EDS). Pitolisant, a selective histamine‐3 receptor antagonist, is efficacious at doses up to 20 mg once daily in OSA treated or not with continuous positive airway ...
Yves Dauvilliers, S. Craig, M. Bonsignore, Ferran Barbé, J. Verbraecken, Jerryll Asin, O. Georgiev, R. Tiholov, C. Caussé, J. Lecomte, J. Schwartz, P. Lehert, Winfried J. Randerath, J. Pépin, Dejan Hristo Iliev Zdravka Ventsislav Daniel Dokic Metev Kartev Karamyan Nozharov Petkov, Dejan Dokic, H. Metev, Iliev Kartev, Zdravka Karamyan, Ventsislav Nozharov, Daniel I. Petkov   +20 more
semanticscholar   +1 more source

Histamine H3 receptor inverse agonists/antagonists influence intra-regional cortical activity and inter-regional synchronization during resting state: an exploratory cortex-wide imaging study in mice

Molecular Brain
The histaminergic system plays a key role in modulating learning and memory, wakefulness, and energy balance. Histamine H3 receptors constitutively inhibit the synthesis and release of histamine and other neurotransmitters. Therefore, H3 receptor inverse
Sentaro Kaita, Yoshikazu Morishita, Kenta Kobayashi, Hiroshi Nomura   +3 more
doaj   +1 more source

The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats

Frontiers in Pharmacology, 2017
The involvement of histamine H3 receptors (H3Rs) in memory is well known, and the potential of H3R antagonists in therapeutic management of neuropsychiatric diseases, e.g., Alzheimer disease (AD) is well established.
Alaa Alachkar, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sadek   +3 more
doaj   +1 more source

Drugs affecting sleep and wakefulness: a review [PDF]

, 2018
It was in the second half of the twentieth century that Sleep Medicine was recognized as an immensely respected field of clinical research. As a result, past few decades have seen this field making some giant strides towards a better understanding of the
Amar, Avishek
core   +2 more sources

Treatment of narcolepsy and pregnancy: a review

Sleep Science and Practice
This is a chapter review of pregnancy state in patients with narcolepsy which aims to provide a review of literature regarding pregnancy in patients with narcolepsy, physiology of hormonal change during pregnancy on sleep, pharmacologic and non ...
Kullatham Kongpakpaisarn, Christine Won
doaj   +1 more source

Obstructive Sleep Apnoea Treatments—Where Are We Now?

Respirology, Volume 30, Issue 10, Page 920-922, October 2025.
Steven Luu, Donald Lee, Brendon J. Yee
wiley   +1 more source

Histamine and migraine revisited: mechanisms and possible drug targets

The Journal of Headache and Pain, 2019
Objective To review the existing literature on histamine and migraine with a focus on the molecule, its receptors, its use in inducing migraine, and antihistamines in the treatment of migraine. Background Histamine has been known to cause a vascular type
Jacob Worm, Katrine Falkenberg, Jes Olesen   +2 more
doaj   +1 more source

The histamine H3 receptor: from discovery to clinical trials with pitolisant [PDF]

British Journal of Pharmacology, 2011
The third histamine receptor was discovered in 1983 by a traditional pharmacological approach, consisting of assessing the inhibitory effect of histamine on its own release from depolarized rat brain slices. The samein vitrotest was used to design, in 1987, the first highly selective and potent H3‐autoreceptor ligands, the antagonist thioperamide and ...
openaire   +2 more sources

Recent advances in treatment for narcolepsy

Therapeutic Advances in Neurological Disorders, 2019
Narcolepsy type 1 (NT1) is a chronic orphan disorder, caused by the selective and irreversible loss of hypocretin/orexin (ORX) neurons, by a probable autoimmune process.
Lucie Barateau, Yves Dauvilliers
doaj   +1 more source

Novel Pharmacological Strategies for the Management of Insomnia [PDF]

, 2017
Insomnia is a common sleep disorder depicted as a difficulty in initiating or maintaining sleep, or non-restorative sleep with impairment of day time functioning, such as irritability or fatigue during wakefulness.
Alberto Kousuke de la Herran-Arita, Deldhy Nicolas Moya-Sánchez, Hector Ramses Lopez-Lazcano, Roberto Miranda-Maciel   +3 more
core   +1 more source