PLoS ONE, 2022 Metal-dependent histone deacetylases (HDACs) are essential epigenetic regulators; their molecular and pharmacological roles in medically critical diseases such as neuropsychiatric disorders, neurodegeneration, and cancer are being studied globally. HDAC2'
Anupam Raja +4 more
doaj +3 more sources
Neurologijos seminarai, 2020 In this review article, we present the treatment of narcolepsy since ancient times when patients experiencing the phenomenon of incubus (today understood as sleep paralysis with hypnagogic or hypnopompic hallucinations) were “cured” during the sessions ...
E. Sakalauskaitė-Juodeikienė +1 more
doaj +1 more source
Sites of action of sleep and wake drugs: insights from model organisms [PDF]
, 2013 Small molecules have been used since antiquity to regulate our sleep. Despite the explosion of diverse drugs to treat problems of too much or too little sleep, the detailed mechanisms of action and especially the neuronal targets by which these compounds
Rihel, J, Schier, AF
core +1 more source
Investigation and management of residual sleepiness in CPAP-treated patients with obstructive sleep apnoea: the European view [PDF]
, 2022 Excessive daytime sleepiness (EDS) is a major symptom of obstructive sleep apnoea (OSA), defined as the inability to stay awake during the day. Its clinical descriptors remain elusive, and the pathogenesis is complex, with disorders such as insufficient
Asin, Jerryll +7 more
core +1 more source
Narcolepsy and Cataplexy – a practical approach to diagnosis and managing the impact of this chronic condition on children and their families [PDF]
, 2017 Narcolepsy is a relatively common neurological condition affecting the regulation of normal sleep/wake cycles leading to excessive daytime sleepiness (EDS).
Blackwell, J +3 more
core +1 more source
Genetic Analysis of Histamine Signaling in Larval Zebrafish Sleep [PDF]
, 2017 Pharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake ...
Chen, Audrey +3 more
core +1 more source
Dysregulation of BDNF and PI3K/Akt signaling in the brain of female Wistar-Kyoto rats exposed to chronic mild stress [PDF]
, 2023 Background: The neurobiology underlying depression has not yet been fully identified, but is thought to result from molecular and cellular abnormalities that interact with genetic and environmental factors. Depression is twice as prevalent in women as in
Dronjak, Slađana +5 more
core +1 more source
Efficacy of Pitolisant on the Treatment of Narcolepsy: A Systematic Review [PDF]
Cureus, 2021 Narcolepsy is characterized by excessive daytime sleepiness (EDS) and cataplexy. Histamine neurons play an important role in enhancing wakefulness. The objective of our study was to evaluate the efficacy of pitolisant, a histamine 3 (H3)-receptor antagonist/inverse agonist, in patients with a high burden of narcolepsy symptoms. We conducted an advanced
Fabara, Stephanie P +6 more
openaire +2 more sources
Sleep Disorders in Adults with Prader-Willi Syndrome: Review of the Literature and Clinical Recommendations Based on the Experience of the French Reference Centre [PDF]
, 2022 Prader–Willi syndrome (PWS) is a rare, genetic, multisymptomatic, neurodevelopmental disease commonly associated with sleep alterations, including sleep-disordered breathing and central disorders of hypersomnolence.
Alice Bellicha +7 more
core +1 more source
Long-term efficacy and safety of pitolisant for residual sleepiness due to Obstructive Sleep Apnea.
Chest, 2023 BACKGROUND In people with obstructive sleep apnea (OSA) excessive daytime sleepiness is a prominent symptom and can persist despite adherence to continuous positive airway pressure (CPAP), the first line therapy for OSA.
Jean-Louis Pépin +9 more
semanticscholar +1 more source