Results 81 to 90 of about 1,197 (187)
Brain and Behavior, Volume 15, Issue 10, October 2025.Orexin deficiency drives narcolepsy Type 1, leading to excessive daytime sleepiness, cataplexy, and REM intrusions. This review highlights recent advances (2023–2025) in molecular mechanisms, diagnostics, and emerging orexin‐targeted therapies with the potential for disease modification.
Rameesha Rauf +9 more
wiley +1 more source
Advances in Clinical Neuroscience & Rehabilitation, 2016 Narcolepsy is thought to affect 0.05% of Caucasian populations and frequently causes severe symptoms across the 24-hour period. It is best viewed as a disorder of sleep-wake regulation with particular abnormalities of the rapid eye movement (REM ...
Paul Reading
doaj +1 more source
Journal of Sleep Research, Volume 34, Issue 5, October 2025.ABSTRACT Parasomnias are abnormal behaviours or mental experiences during sleep or the sleep–wake transition. As disorders of arousal (DOA) or REM sleep behaviour disorder (RBD) can be difficult to capture in the sleep laboratory and may need to be diagnosed in large communities, new home diagnostic devices are being developed, including actigraphy ...
Claudia Picard‐Deland +5 more
wiley +1 more source
Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats [PDF]
, 2016 A series of twelve novel non-imidazole-based ligands (3-14) was developed and evaluated for its in vitro binding properties at the human histamine H3 receptor (hH3R).
Karcz, Tadeusz +7 more
core +2 more sources
Present and Future of Central Disorders of Hypersomnolence
Journal of Sleep Research, Volume 34, Issue 5, October 2025.ABSTRACT Central disorders of hypersomnolence (CDH) are rare neurological conditions lumped by excessive daytime sleepiness (EDS) as primary complaint mostly arising at young age, including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), idiopathic hypersomnia (IH), and Kleine‐Levin syndrome (KLS). Advances in clinical and translational research have
Francesco Biscarini +4 more
wiley +1 more source
Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice [PDF]
, 2019 Most cells acquire cholesterol by endocytosis of circulating lowdensity lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms.
Colaco, Alexandria +11 more
core +2 more sources
Are Inverse Agonists of the Histamine H3 Receptor Effective in Reducing Excessive Daytime Sleepiness (EDS) in Individuals with Sleep Disorders? [PDF]
, 2018 OBJECTIVE: The objective of this systematic review is to determine whether or not “Are inverse agonists of the Histamine H3 receptor effective in reducing excessive daytime sleepiness (EDS) in individuals with sleep disorders?” DESIGN: Review of two ...
Peters, Kelly-Ann
core +1 more source
Movement Disorders, Volume 40, Issue 9, Page 1919-1929, September 2025.Abstract Background Excessive daytime sleepiness (EDS) is a disabling symptom of Lewy body disorders (LBD). The hypothalamus is a key sleep–wake regulator and is involved in Lewy pathology, but its contribution to EDS in LBD remains unclear. Objectives To use diffusion‐weighted magnetic resonance imaging (MRI) to detect hypothalamic microstructure and ...
Jesse S. Cohen +8 more
wiley +1 more source
New developments in the management of narcolepsy
Nature and Science of Sleep, 2017 Vivien C Abad, Christian Guilleminault Department of Psychiatry and Behavioral Sciences, Division of Sleep Medicine, Stanford University Outpatient Center, Redwood City, CA, USA Abstract: Narcolepsy is a life-long, underrecognized sleep disorder ...
Abad VC, Guilleminault C
doaj
Narcolepsy: a machine learning bibliometric analysis (1996–2024)
Frontiers in NeurologyBackgroundNarcolepsy is a rare neurological cause of chronic sleepiness. This study aimed to better understand global narcolepsy through bibliometric analysis.MethodsArticles and reviews on narcolepsy were sourced from the Web of Science Core Collection.
Minheng Zhang +3 more
doaj +1 more source