Results 21 to 30 of about 416,939 (310)

Surgical Outcomes of Clival Chordoma Through Endoscopic Endonasal Approach: A Single-Center Experience

Frontiers in Endocrinology, 2022
ObjectiveClival chordoma is a locally aggressive tumor with low metastatic potential. In the past decade, endoscopic endonasal approach (EEA) for clival chordoma has had a higher resection rate and a lower morbidity rate than transcranial approaches ...
Ge Chen, Ge Chen, Mingchu Li, Mingchu Li, Wenlong Xu, Wenlong Xu, Xu Wang, Xu Wang, Ming Feng, Ming Feng, Renzhi Wang, Renzhi Wang, Xiaohai Liu, Xiaohai Liu   +13 more
doaj   +1 more source

Clinical Efficacy of Temozolomide and Its Predictors in Aggressive Pituitary Tumors and Pituitary Carcinomas: A Systematic Review and Meta-Analysis

Frontiers in Neurology, 2021
Background: A growing number of evidences suggest that TMZ applications can generate impressive benefits for APT and PC patients. However, the definite role of TMZ for individuals remains unclarified due to the variation between studies.
Mei Luo, Yiheng Tan, Wenli Chen, Bin Hu, Zongming Wang, Diming Zhu, Haosen Jiao, Chengbin Duan, Yonghong Zhu, Haijun Wang   +9 more
doaj   +1 more source

Genetic regulation of pituitary gland development in human and mouse [PDF]

, 2009
Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Robin Lovell-Badge, Dattani, M. T., Robinson, I. C. A. F., Mehul T. Dattani, Lovell-Badge, R., Karine Rizzoti, Iain C. A. F. Robinson, Rizzoti, K., Kelberman, D., Daniel Kelberman   +9 more
core   +1 more source

Preoperative Fasting C-Peptide Acts as a Promising Predictor of Improved Glucose Tolerance in Patients With Acromegaly After Transsphenoidal Surgery: A Retrospective Study of 64 Cases From a Large Pituitary Center in China

Frontiers in Endocrinology, 2019
Purpose: Abnormal glucose metabolism is one of the most frequent acromegaly complications. Improvement of glucose metabolism can be observed only in half of acromegaly patients after surgery.
Zihao Wang, Zihao Wang, Lu Gao, Lu Gao, Xiaopeng Guo, Xiaopeng Guo, Chenzhe Feng, Chenzhe Feng, Kan Deng, Kan Deng, Wei Lian, Wei Lian, Ming Feng, Ming Feng, Xinjie Bao, Xinjie Bao, Bing Xing, Bing Xing   +17 more
doaj   +1 more source

Automatic Detection for Acromegaly Using Hand Photographs: A Deep-Learning Approach

IEEE Access, 2021
Machine learning assisted diagnosis of acromegaly from facial photographs has been proved feasible in recent years. According to our previous research, facial and limb changes exist in patients with acromegaly at early stage.
Chengbin Duan, Wenli Chen, Shun Yao, Zhigang Mao, Zongming Wang, Bin Hu, Haosen Jiao, Dimin Zhu, Yonghong Zhu, Haijun Wang   +9 more
doaj   +1 more source

Mechanisms for pituitary tumorigenesis: the plastic pituitary [PDF]

Journal of Clinical Investigation, 2003
The anterior pituitary gland integrates the repertoire of hormonal signals controlling thyroid, adrenal, reproductive, and growth functions. The gland responds to complex central and peripheral signals by trophic hormone secretion and by undergoing reversible plastic changes in cell growth leading to hyperplasia, involution, or benign adenomas arising ...
openaire   +2 more sources

Generation of isogenic and homozygous MEN1 mutant cell lines from patient-derived iPSCs using CRISPR/Cas9

Stem Cell Research, 2023
MEN1, an autosomal dominant disorder caused by mutations in the tumor suppressor gene MEN1, manifests with co-occurrence of multiple endocrine/neuroendocrine neoplasms. An iPSC line derived from an index patient carrying the mutation c.1273C>T (p.Arg465*)
Naomi Even-Zohar, Derya Metin-Armagan, Anat Ben-Shlomo, Dhruv Sareen, Shlomo Melmed   +4 more
doaj   +1 more source

Treatment of Aggressive Pituitary Adenomas: A Case-Based Narrative Review

Frontiers in Endocrinology, 2021
Management of aggressive pituitary adenomas is challenging due to a paucity of rigorous evidence supporting available treatment approaches. Recent guidelines emphasize the need to maximize standard therapies as well as the use of temozolomide and ...
Odelia Cooper, Vivien Bonert, Ning-Ai Liu, Adam N. Mamelak, Adam N. Mamelak   +4 more
doaj   +1 more source

Pituitary apoplexy : can histopathology, radiological imaging and predisposing factors be used in predicting outcome? [PDF]

, 2008
Includes abstract.Includes bibliographical references (leaves 98-112).Pituitary apoplexy is an uncommon, yet potentially fatal illness, usually the result of infarction, hemorrhage or a combination of both in a pituitary tumor.
Semple, Patrick Lyle
core   +1 more source

Prediction of the Recurrence of Non-Functioning Pituitary Adenomas Using Preoperative Supra-Intra Sellar Volume and Tumor-Carotid Distance

Frontiers in Endocrinology, 2021
BackgroundCurrently, it is difficult to estimate the possibility of recurrence of nonfunctioning pituitary adenomas (NFPAs). Markers such as Ki-67 or transcription factors rely on postoperative pathology, while few indices can be used for preoperative ...
Wenli Chen, Mengqi Wang, Chengbin Duan, Shun Yao, Haosen Jiao, Zongming Wang, Bin Hu, Zhigang Mao, Yonghong Zhu, Haijun Wang   +9 more
doaj   +1 more source