Results 41 to 50 of about 162,638 (311)
A unified model for the human response to lipopolysaccharide-induced inflammation [PDF]
arXiv, 2022 This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and anti-inflammatory cytokines (TNF-$\alpha$, IL-6, IL-10), concentrations of corticotropin-releasing hormone (CRH ...
arxiv
Follicle-stimulating hormone receptor: Advances and remaining challenges [PDF]
In: Arun K. Shukla (ed.), dir., G Protein-Coupled Receptors:
Emerging Paradigms in Activation, Signaling and Regulation Part A (p. 1-58).
International Review of Cell and Molecular Biology, 338 (1\`ere ed.). USA :
Elsevier. 171 p. (2018), 2018 Follicle-stimulating hormone (FSH) is produced in the pituitary and is essential for reproduction. It specifically binds to a membrane receptor (FSHR) expressed in somatic cells of the gonads. The FSH/FSHR system presents many peculiarities compared to classical G protein-coupled receptors (GPCRs).
arxiv +1 more source
PLoS ONE, 2022 Introduction Obesity is characterized by elevated lipids, insulin resistance and relative hypogonadotropic hypogonadism, reducing fertility and increasing risk of pregnancy complications and birth defects.
Rosemary McDonald +6 more
doaj +2 more sources
Basal Glucose Control in Type 1 Diabetes using Deep Reinforcement Learning: An In Silico Validation [PDF]
IEEE journal of biomedical and health informatics 2020, 2020 People with Type 1 diabetes (T1D) require regular exogenous infusion of insulin to maintain their blood glucose concentration in a therapeutically adequate target range. Although the artificial pancreas and continuous glucose monitoring have been proven to be effective in achieving closed-loop control, significant challenges still remain due to the ...
arxiv +1 more source
Annotation of pituitary neuroendocrine tumors with genome-wide expression analysis
Acta Neuropathologica Communications, 2021 Pituitary neuroendocrine tumors (PitNETs) are common, generally benign tumors with complex clinical characteristics related to hormone hypersecretion and/or growing sellar tumor mass.
Abdellah Tebani +9 more
doaj +1 more source
Stability analysis of a hypothalamic-pituitary-adrenal axis model with inclusion of glucocorticoid receptor and memory [PDF]
AIP Conference Proceedings 1798, 020111, 2017, 2016 This paper analyzes a four-dimensional model of the hypothalamic-pituitary-adrenal (HPA) axis that includes the influence of the glucocorticoid receptor in the pituitary. Due to the spatial separation between the hypothalamus, pituitary and adrenal glands, distributed time delays are introduced in the mathematical model.
arxiv +1 more source
The Processes of Anterior Pituitary Hormone Pulse Generation
Endocrinology, 2018 More than 60 years ago, Geoffrey Harris described his "neurohumoral theory," in which the regulation of pituitary hormone secretion was a "simple" hierarchal relationship, with the hypothalamus as the controller.
P. L. Le Tissier +2 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 1985 To determine the physiological significance of corticotropin-releasing factor (CRF) in the control of pituitary hormone secretion, highly specific antibodies directed against the peptide were injected either intravenously or intraventricularly (third ...
N. Ono +5 more
semanticscholar +1 more source
Intraoral Drug Delivery: Bridging the Gap Between Academic Research and Industrial Innovations
Advanced Functional Materials, EarlyView.Intraoral drug delivery offers a promising route for systemic and localized therapies, yet challenges such as enzymatic degradation, limited permeability, and microbial interactions hinder efficacy. This figure highlights innovative strategies—mucoadhesive materials, enzyme inhibitors, and permeation enhancers—to overcome these barriers.
Soheil Haddadzadegan +4 more
wiley +1 more source
Pituitary Adenoma: A Short Illustrative Review
Indian Journal of Neurosurgery, 2016 The pituitary gland is located below the brain in a depression of sphenoid bone known as sella turcica. It controls most of the body's endocrine functions via the secretion of various hormones into the circulatory system.
Sharada Rane +3 more
doaj +1 more source