Results 241 to 250 of about 322,068 (275)

Activity of protein kinase C controls the efficacy of cannabinoid receptor type 1 in the medial prefrontal cortex after neuropathic pain. [PDF]

J Neurophysiol
Chao D, Liu Y, Cheng T, Hogan QH, Pan B.
europepmc   +1 more source

Hormone-sensitive lipase drives pro-resolving macrophage polarization and enhances efferocytosis. [PDF]

Cell Commun Signal
Watanabe H, Palacio B, Lee M, Sul HS, Kim J, Diamond B, Son M.   +6 more
europepmc   +1 more source

Electronic and Steric Tuning of Molecular Acidity toward Unified Models for Excited State Proton Transfer. [PDF]

Adv Sci (Weinh)
Chen C, Myasnyanko IN, Baranov MS, Fang C.   +3 more
europepmc   +1 more source

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PKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis

Physiological Reviews, 2005
Stimulus-secretion coupling is an essential process in secretory cells in which regulated exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While an increase in intracellular Ca2+concentration ([Ca2+]i) is the principal signal, other intracellular signals also are important in regulated exocytosis. In particular, the
Susumu, Seino, Tadao, Shibasaki
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Standardization of prekallikrein activator (PKA): the 1st International Standard for PKA

British Journal of Haematology, 1985
SummaryA international collaborative study was carried out to establish an international standard for prekallikrein activator (PKA). The candidate material, coded 82/530, was assayed against the Office of Biologics (FDA) PKA reference preparation No. 2 (OoB 2) and the 1st British Reference Preparation for PKA.
P J, Kerry, A D, Curtis, D P, Thomas
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PKA, Germ Cells, and Fertility

Physiology, 2007
Temporal and spatial regulation of PKA activity are essential for vigorous sperm motility and for the resumption of meiosis in oocytes, two events required for successful fertilization. Genetic mutations in mice that affect PKA signaling in germ cells lead to infertility and illustrate the importance of this pathway in mammalian reproduction.
Kimberly A, Burton, G Stanley, McKnight
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PKA

2008
Edward H. Kerns, Li Di
  +6 more sources

pKa

2020
Arguably, this is even more important than the previous one. Remember that we use the pK a scale to quantify the stability of carbanions. If it isn’t stable (high pKa) then it won’t be easy to form.
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Database Mining for pKa Prediction

Current Drug Discovery Technologies, 2005
The acid dissociation constant (pKa) is the key parameter to define the extent of ionization of a drug molecule and is used for ADME properties evaluation via the pH-dependent distribution coefficient, logD. We present a method for pKa prediction using a predefined reference database and structural fingerprints based on a multilevel neighborhoods ...
Thierry, Kogej, Sorel, Muresan
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PKA-activation mechanism revised

Science, 2017
Signal Transduction Many hormone receptors stimulate production of cyclic AMP (adenosine monophosphate), which activates PKA (protein kinase A). The textbook view suggests that activation releases the catalytic subunit of the enzyme from its complex with the regulatory subunit. Smith et al.
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