Results 71 to 80 of about 14,270 (217)

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

PSMD14 Transcriptionally Activated by MEF2A Promotes Pancreatic Cancer Development by Upregulating SPON2 Expression

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Proteasome 26S subunit non‐ATPase 14 (PSMD14) plays a pro‐carcinogenic role in various cancers. However, its specific effects and mechanisms in pancreatic cancer (PC) remain unclear. We aimed to assess the function and mechanism of PSMD14 in PC.
Yun‐He Hao, Cheng‐Ru Yang, Wu‐Jiang Shi, Xiang‐Yu Zhong   +3 more
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Tumor M2-PK: A novel urine marker of bladder cancer.

PLoS ONE, 2019
PurposeBladder cancer is a "Warburg-like" tumor characterized by a reliance on aerobic glycolysis and expression of pyruvate kinase M2 (PKM2). PKM2 oscillates between an active tetramer and an inactive dimer.
Weiya Liu, Benjamin L Woolbright, Karim Pirani, Ryan Didde, Erika Abbott, Gaurav Kaushik, Paige Martin, Jill Hamilton-Reeves, John A Taylor, Jeffrey M Holzbeierlein, Shrikant Anant, Eugene K Lee   +11 more
doaj   +1 more source

PKM2 Promotes Breast Cancer Progression by Regulating Epithelial Mesenchymal Transition

Analytical Cellular Pathology, 2020
Breast cancer is the leading cause of females characterized by high invasive potential. It is necessary to explore the underlying mechanism of breast cancer metastases and to find specific therapeutic targets. PKM2 is considered a new biomarker of cancer
Hui Xiao, Longxiao Zhang, Yuan Chen, Chengjun Zhou, Xiao Wang, Dehai Wang, Zhenzhong Liu   +6 more
doaj   +1 more source

PPARγ contributes to PKM2 and HK2 expression in fatty liver [PDF]

Nature Communications, 2012
Rapidly proliferating cells promote glycolysis in aerobic conditions, to increase growth rate. Expression of specific glycolytic enzymes, namely pyruvate kinase M2 and hexokinase 2, concurs to this metabolic adaptation, as their kinetics and intracellular localization favour biosynthetic processes required for cell proliferation.
Morris J. Birnbaum, Jean-Yves Scoazec, Marco Pontoglio, Yasuo Horie, Ganna Panasyuk, Francisco Verdeguer, Lluis Fajas, Céline Chauvin, Jean-Sébastien Annicotte, Akira Suzuki, Akira Suzuki, Marc Foretz, Ludivine A. Pradelli, Catherine Espeillac, Pascal Ferré, Jean-Ehrland Ricci, Mario Pende   +16 more
openaire   +6 more sources

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

Resveratrol inhibits cancer cell metabolism by down regulating pyruvate kinase M2 via inhibition of mammalian target of rapamycin. [PDF]

PLoS ONE, 2012
Metabolism of cancer cells with pyruvate kinase M2 (PKM2) at its centre stage has assumed a prime significance in cancer research in recent times. Cancer cell metabolism, characterized by enhanced glucose uptake, production of lactate and anabolism is ...
Mohd Askandar Iqbal, Rameshwar N K Bamezai   +1 more
doaj   +1 more source

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation [PDF]

Protein & Cell, 2019
A change in the metabolic flux of glucose from mitochondrial oxidative phosphorylation (OXPHOS) to aerobic glycolysis is regarded as one hallmark of cancer. However, the mechanisms underlying the metabolic switch between aerobic glycolysis and OXPHOS are unclear.
Jinbo Han, Xiao Hu, Yiguo Wang, Tong Li, Liqun Chen, Liangjie Jia   +5 more
openaire   +4 more sources

Exosomal PKM2: A Noninvasive Diagnostic Marker Linking Macrophage Metabolic Reprogramming to Gastric Cancer Pathogenesis

Cancer Science, EarlyView.
Plasma exosomal PKM2 is a promising novel biomarker for early gastric cancer diagnosis. It activates the SREBP1‐mediated lipid synthesis pathway in macrophages, promoting their alternative activation and thereby driving tumor progression. ABSTRACT Tumor‐derived exosomes (TDEs) have emerged as vital biomarkers of multiple cancers.
Mengyun Yuan, Xiaoxia Zheng, Shanshan Zheng, Huaizhi Li, Xingxing Zhang, Yuxuan Chen, Xiang Zhang, Bo Han, Wei Wei, Jian Wu, Qingmin Sun   +10 more
wiley   +1 more source