Results 71 to 80 of about 18,059 (264)

ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment

Molecular Cancer
Background The hypoxic tumor microenvironment is a key factor that promotes metabolic reprogramming and vascular mimicry (VM) in ovarian cancer (OC) patients.
Juan Zhang, Ouyang Fan, An-bo Gao, Tian Zeng, Ming Li, Hui Li, Wen-chao Zhou, Qing Gao, Xing Tang, Qun-feng Zhang, Xiao-min Ran, Gang Tian, Xiyun Quan, Zhen-zi Tang, Juan Zou, Yifei Zeng, Yunzhu Long, Yukun Li   +17 more
semanticscholar   +1 more source

CIP2A induces PKM2 tetramer formation and oxidative phosphorylation in non-small cell lung cancer

Cell Discovery
Tumor cells are usually considered defective in mitochondrial respiration, but human non-small cell lung cancer (NSCLC) tumor tissues are shown to have enhanced glucose oxidation relative to adjacent benign lung.
L. Liang, Fu-ying Yang, Di Wang, Yan-Fei Zhang, Hong Yu, Zheng Wang, Bei-bei Sun, Yu-Tao Liu, Gui-zhen Wang, Guang-Biao Zhou   +9 more
semanticscholar   +1 more source

Shikonin improves pulmonary vascular remodeling in monocrotaline‑induced pulmonary arterial hypertension via regulation of PKM2

Molecular Medicine Reports, 2023
Pulmonary arterial hypertension (PAH), a fatal disease with an insidious onset and rapid progression, shows characteristics such as increases in pulmonary circulatory resistance and pulmonary arterial pressure, and progressive right heart failure ...
Wenfeng Li, Wen-Juan Chen, Hongyan Peng, Zhenghui Xiao, Jinqiao Liu, Yunhong Zeng, Ting Huang, Qingqing Song, Xun Wang, Yunbin Xiao   +9 more
semanticscholar   +1 more source

PKM2‐Driven Lactate Overproduction Triggers Endothelial‐To‐Mesenchymal Transition in Ischemic Flap via Mediating TWIST1 Lactylation

Advancement of science
The accumulation of lactate is a rising risk factor for patients after flap transplantation. Endothelial‐to‐mesenchymal transition (EndoMT) plays a critical role in skin fibrosis.
Yining Xu, Xianhui Ma, Weiyu Ni, Lin Zheng, Zhongnan Lin, Yingying Lai, Ningning Yang, Zhanqiu Dai, Teng Yao, Zeyang Chen, Lifeng Shen, Haitao Wang, Long Wang, Yizheng Wu, W. Gao   +14 more
semanticscholar   +1 more source

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis

Cell Death and Disease, 2022
N6-methyladenosine modification is the most common RNA modification mechanism in mammals. YTHDF1, a m6A reader, can recognize the m6A of mRNAs to facilitate the interaction with the mRNA ribosome assembly and recruitment of translation initiators to ...
Xuemei Yao, Wei Li, Liqi Li, Menghuan Li, Youbo Zhao, De-xin Fang, Xiaohua Zeng, Zhong Luo   +7 more
semanticscholar   +1 more source

ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy

Journal of Translational Medicine, 2023
Background Glycolysis under normoxic conditions, known as the Warburg effect, confers a selective advantage for the survival and proliferation of many tumors. In this study, we investigated the role of estrogen-related receptor gamma (ESRRG) in metabolic
Tianxiao Wang, Yongjun Zhu, Lu Chen, Wenxin Zhang, H. Qi, Xiaojin Shi, Mingkang Zhong, Haifei Chen, Qunyi Li   +8 more
semanticscholar   +1 more source

HSP90 promotes cell glycolysis, proliferation and inhibits apoptosis by regulating PKM2 abundance via Thr-328 phosphorylation in hepatocellular carcinoma

Molecular Cancer, 2017
Background Heat shock protein 90 (HSP90) functions as a well-known onco-protein to regulate protein conformation, stability and degradation. Pyruvate kinase M2 (PKM2), a critical regulator of the metabolism, growth and metastasis of cancer cells, has ...
Qiuran Xu, Jianfeng Tu, Changwei Dou, Jun Zhang, Liu Yang, Xin Liu, Kefeng Lei, Zhikui Liu, Yufeng Wang, Lijie Li, Hangxing Bao, Jiahui Wang, Kangsheng Tu   +12 more
doaj   +1 more source

Pan-Cancer Analysis of the Oncogenic and Prognostic Role of PKM2: A Potential Target for Survival and Immunotherapy

BioMed Research International, 2023
Background No pan-cancer study has been conducted till date to explore the comprehensive oncogenic roles of pyruvate kinase M2 (PKM2). Methods TCGA, TIMER, GEPIA, UALCAN, STRING, and other databases were used to analyze the expression, prognostic roles ...
N. Liang, L. Mi, Jingting Li, Tong Li, Jun Chen, G. Dionigi, Haixia Guan, Hui Sun   +7 more
semanticscholar   +1 more source

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Mutant p53 and mTOR/PKM2 regulation in cancer cells [PDF]

IUBMB Life, 2016
AbstractMutations of TP53 gene are the most common feature in aggressive malignant cells. In addition to the loss of the tumor suppressive role of wild‐type p53, hotspot mutant p53 isoforms display oncogenic proprieties notoriously referred as gain of functions (GOFs) which result in chemoresistance to therapies, genomic instability, aberrant ...
DANDO, Ilaria, CORDANI, MARCO, DONADELLI, Massimo   +2 more
openaire   +5 more sources