Results 41 to 50 of about 2,539 (164)

Data_Sheet_1_Genomic and clinical characterization of Klebsiella pneumoniae carrying the pks island.pdf

, 2023
BackgroundThe pks island and its production of the bacterial secondary metabolite genotoxin, colibactin, have attracted increasing attention. However, genomic articles focusing on pks islands in Klebsiella pneumoniae, as well as comparative genomic ...
Zijuan Jian (15544160), Awen Yang, Qun Yan (122601), Yanjun Liu, Bin Tang, Zhiqian Wang, Qun Yan, Zhiqian Wang (1519756), Bin Tang (56654), Peilin Liu, Wenen Liu (14039727), Awen Yang (15544157), Zijuan Jian, Peilin Liu (3510071), Wenen Liu, Yanjun Liu (367302)   +15 more
core   +1 more source

Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis. [PDF]

PLoS ONE, 2018
Immune-compromised mouse models allow for testing the preclinical efficacy of human cell transplantations and gene therapy strategies before moving forward to clinical trials.
Vasudevan Bakthavatchalu, Katherine J Wert, Yan Feng, Anthony Mannion, Zhongming Ge, Alexis Garcia, Kathleen E Scott, Tyler J Caron, Carolyn M Madden, Johanne T Jacobsen, Gabriel Victora, Rudolf Jaenisch, James G Fox   +12 more
doaj   +1 more source

Insights into the phylogenetic diversity, biological activities, and biosynthetic potential of mangrove rhizosphere Actinobacteria from Hainan Island

Frontiers in Microbiology, 2023
Mangrove rhizosphere soils host diverse Actinobacteria tolerant to numerous stresses and are inevitably capable of exhibiting excellent biological activity by producing impressive numbers of bioactive natural products, including those with potential ...
Jing-jing Ye, Ren-jian Zou, Dong-dong Zhou, Xiao-lin Deng, Ni-lin Wu, Dan-dan Chen, Jing Xu   +6 more
doaj   +1 more source

Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells. [PDF]

PLoS ONE, 2013
Cellular senescence is an irreversible state of proliferation arrest evoked by a myriad of stresses including oncogene activation, telomere shortening/dysfunction and genotoxic insults. It has been associated with tumor activation, immune suppression and
Thomas Secher, Ascel Samba-Louaka, Eric Oswald, Jean-Philippe Nougayrède   +3 more
doaj   +1 more source

Presence of Biosynthetic Gene Clusters (NRPS/PKS) in Actinomycetes of Mangrove Sediment in Semarang and Karimunjawa, Indonesia

Environment and Natural Resources Journal, 2021
Actinomycetes are a group of bacteria that are widely distributed in soil, litter, water, and other natural sources. These Gram positive bacteria can produce hundreds of bioactive compounds, especially antibiotics.
Amelia Cahya Anggelina, Delianis Pringgenies, Wilis Ari Setyati   +2 more
doaj   +1 more source

Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coli.

PLoS Pathogens, 2013
In Escherichia coli, the biosynthetic pathways of several small iron-scavenging molecules known as siderophores (enterobactin, salmochelins and yersiniabactin) and of a genotoxin (colibactin) are known to require a 4'-phosphopantetheinyl transferase ...
Patricia Martin, Ingrid Marcq, Giuseppe Magistro, Marie Penary, Christophe Garcie, Delphine Payros, Michèle Boury, Maïwenn Olier, Jean-Philippe Nougayrède, Marc Audebert, Christian Chalut, Sören Schubert, Eric Oswald   +12 more
doaj   +1 more source

Prevalence and Characterization of Some Colibactin Genes in Clinical Enterobacteriaceae isolates from Iraqi Patients

مجلة بغداد للعلوم, 2020
The members of the family of Eentrobacteriaceae harbour a gene cluster called polyketide synthase (pks) island. This cluster is responsible for the synthesis of the genotoxin colibactin that might have an important role in the induction of double-strand ...
Mohammed T. Hussein, Safaa ahmed S. Al-Qaysi, Munther H. Rathi, Qasim I. Hussein, Tarek A.A. Moussa   +4 more
doaj   +1 more source

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, EarlyView.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Investigating the Prevalence of PK Island in Enterobacteriacea

Medical Science Journal for Advance Research
The Enterobacteriaceae family has a pathogenicity island that leads to increase in pathogenicity. Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island.
Noor Ismeal Nasser, Fatima Hamza Alzubaidy, Taif Al-Saadi, Qassim M. Hashym, Sura Abdul-Aziz Najem   +4 more
openaire   +1 more source

Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

, 2016
Colibactin is a structurally uncharacterized, genotoxic natural product produced by commensal and pathogenic strains of E. coli that harbor the pks island. A new metabolite has been isolated from a pks+ E.
Emily P. Balskus (1608988), Carolyn A. Brotherton (1608985), Gary Byrd (1608982), Matthew Wilson (1608979)   +3 more
core   +1 more source