Results 51 to 60 of about 2,539 (164)

Incidence Trends of Early‐Onset Colorectal Cancer in Germany: A Registry‐Based Study From 2003 to 2023

International Journal of Cancer, EarlyView.
The evidence on the rising incidence of colorectal cancer among adults below 50 years of age largely stems from the United States. Using high‐quality cancer registry data for the 2003–2023 period in Germany, this study found a moderate increase of early‐onset colorectal cancer incidence that was limited to those aged 20–39 years and more pronounced ...
Sven Voigtländer, Hiltraud Kajüter, Ina Wellmann, Andras Szentkirályi, Bernd Holleczek, Volker Arndt, Jacqueline Müller‐Nordhorn, the ALSTER Working Group, Josephine Kanbach, Sabine Luttmann, Meike Ressing, Cécile Ronckers, Soo‐Zin Kim‐Wanner, Alice Nennecke, Frederik Peters, Klaus Kraywinkel, Roxana Müller‐Eberstein, Hannah Baltus, Paula Grieger, Antje Schliemann, Annika Waldmann   +20 more
wiley   +1 more source

Oligosaccharides increase the genotoxic effect of colibactin produced by pks+ Escherichia coli strains

BMC Cancer, 2021
Background Colibactin is a genotoxin that induces DNA double-strand breaks that may lead to carcinogenesis and is produced by Escherichia coli strains harboring the pks island.
Manon Oliero, Annie Calvé, Gabriela Fragoso, Thibault Cuisiniere, Roy Hajjar, Ulrich Dobrindt, Manuela M. Santos   +6 more
doaj   +1 more source

Reconstruction of deep and perforating corneal defects in dogs—A review (Part I/III): Autogenous ocular tissues, donor tissues, and corneal clarity scoring

Veterinary Ophthalmology, Volume 28, Issue 2, Page 519-531, March 2025.
Abstract Corneal reconstruction is a key part of veterinary ophthalmic practice and numerous reconstructive techniques have been described for use in small animals in the peer‐reviewed veterinary literature written in English. Despite the evidence accrued over the last six decades in over 40 clinical articles and numerous other publications on ocular ...
Rick F. Sanchez, Eric C. Ledbetter, Marta Leiva   +2 more
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen, Yupan Bai, Lu Shen, Jiacheng Ying, Jie Xu, Jiayin Tang, Yujie Bao   +6 more
wiley   +1 more source

Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota

eLife, 2018
As part of the Reproducibility Project: Cancer Biology we published a Registered Report (Eaton et al., 2015) that described how we intended to replicate selected experiments from the paper “Intestinal Inflammation Targets Cancer-Inducing Activity of the ...
Kathryn Eaton, Ali Pirani, Evan S Snitkin, Reproducibility Project: Cancer Biology   +3 more
doaj   +1 more source

Colibactin possessing E. coli isolates in association with colorectal cancer and their genetic diversity among Pakistani population.

PLoS ONE, 2022
Colorectal cancer (CRC) is the third most prevalent cause of tumorigenesis and several pathogenic bacteria have been correlated with aggressive cases of cancer i.e., genotoxin (colibactin) producing Escherichia coli (E. coli).
Habiba Tariq, Zobia Noreen, Aftab Ahmad, Laraib Khan, Mashhood Ali, Muhammad Malik, Aneela Javed, Faisal Rasheed, Alina Fatima, Tanil Kocagoz, Ugur Sezerman, Habib Bokhari   +11 more
doaj   +1 more source

Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?

Medicinal Research Reviews, Volume 46, Issue 4, Page 1111-1151, July 2026.
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca, Mariana Feijó, Cátia V. Vaz, Bruno J. Pereira, Sandra Laurentino, Ana Palmeira‐de‐Oliveira, Sílvia Socorro   +6 more
wiley   +1 more source

Table_1_Molecular Genetic and Functional Analysis of pks-Harboring, Extra-Intestinal Pathogenic Escherichia coli From India.DOCX

, 2018
Colibactin, a genotoxin, encoded by the pks pathogenicity island of Escherichia coli belonging to the B2 phylogroup has been reported as a determinant of bacterial pathogenicity. The present study was carried out to detect the pks pathogenicity island in
Niyaz Ahmed (20828), Arya Suresh (5978012), Arif Hussain (226527), Ramani Baddam (2818021), Savita Jadhav (226520), Amit Ranjan (2109694), Sabiha Shaik (2818015), Munirul Alam (3275067), Lothar H. Wieler (106662)   +8 more
core   +1 more source

Metagenomic Survey of Potential Symbiotic Bacteria and Polyketide Synthase Genes in an Indonesian Marine Sponge

Hayati Journal of Biosciences, 2017
There has been emerging evidence that the bacteria associated with marine sponges are the key producers of many complex bioactive compounds. The as-yet uncultured candidate bacterial genus “Candidatus Entotheonella” of the marine sponge Theonella ...
Nia M. Kurnia, Agustinus R. Uria, Yudi Kusnadi, Lidia Dinawati, Dewi S. Zilda, Tri A. Hadi, Siswa Setyahadi, Feliatra Felix   +7 more
doaj   +1 more source

Genotoxic Klebsiella pneumoniae in Taiwan. [PDF]

PLoS ONE, 2014
BACKGROUND: Colibactin is a nonribosomal peptide-polyketide synthesized by multi-enzyme complexes encoded by the pks gene cluster. Colibactin-producing Escherichia coli have been demonstrated to induce host DNA damage and promote colorectal cancer (CRC ...
Yi-Chyi Lai, Ann-Chi Lin, Ming-Ko Chiang, Yu-Han Dai, Chih-Chieh Hsu, Min-Chi Lu, Chun-Yi Liau, Ying-Tsong Chen   +7 more
doaj   +1 more source