Results 31 to 40 of about 2,539 (164)

Detection Of clbB and clbN Genes in Isolated Klebsiella Pneumoniae of Biopsies from Colorectal Cancer Patient in Erbil Province

Eurasian Journal of Science and Engineering, 2023
Recently, it has been proved that some of Enterobacteriaceae like Klebsiella pneumoniae, which carry polyketide synthase (PKS) islands, damage human dsDNA by encoding Colibactin genotoxin; and finally, they induce some apoptosis in damaged mucosal cells.
Jutiyar Ibrahim, Hêro Farhad Salah
doaj   +1 more source

Tackling the Threat of Cancer Due to Pathobionts Producing Colibactin: Is Mesalamine the Magic Bullet?

Toxins, 2021
Colibactin is a genotoxin produced primarily by Escherichia coli harboring the genomic pks island (pks+ E. coli). Pks+ E. coli cause host cell DNA damage, leading to chromosomal instability and gene mutations.
Min Tang-Fichaux, Priscilla Branchu, Jean-Philippe Nougayrède, Eric Oswald   +3 more
doaj   +1 more source

Detection of Streptococcus gallolyticus and Four Other CRC-Associated Bacteria in Patient Stools Reveals a Potential “Driver” Role for Enterotoxigenic Bacteroides fragilis

Frontiers in Cellular and Infection Microbiology, 2022
PurposeStreptococcus gallolyticus subspecies gallolyticus (SGG) is an opportunistic pathogen causing invasive infections in the elderly often associated with colon neoplasia.
Bruno Périchon, Bruno Périchon, Julian Lichtl-Häfele, Julian Lichtl-Häfele, Emma Bergsten, Vincent Delage, Vincent Delage, Patrick Trieu-Cuot, Patrick Trieu-Cuot, Philippe Sansonetti, Philippe Sansonetti, Iradj Sobhani, Shaynoor Dramsi, Shaynoor Dramsi   +13 more
doaj   +1 more source

Short-term mucosal disruption enables colibactin-producing E. coli to cause long-term perturbation of colonic homeostasis

Gut Microbes, 2023
Colibactin, a bacterial genotoxin produced by E. coli strains harboring the pks genomic island, induces cytopathic effects, such as DNA breaks, cell cycle arrest, and apoptosis.
Christine Harnack, Hilmar Berger, Lichao Liu, Hans-Joachim Mollenkopf, Till Strowig, Michael Sigal   +5 more
doaj   +1 more source

Schematic of an intact pks island coding for colibactin.

, 2023
This cluster consists of 19 genes starting with clbA and ending with clbS. The region of the pks island deleted is shown by dashed lines.
Aida Kalantari (6731369), Mylene Perreault (2004913), Lauren A. Renaud (14559642), Mary N. McDonald (14559648), David L. Hava (14559651), Michael J. James (336941), Vincent M. Isabella (14559654), Catherine E. Monahan (14559645)   +7 more
core   +1 more source

Actinomycetes of secondary metabolite producers from mangrove sediments, Central Java, Indonesia [PDF]

Veterinary World, 2021
Background and Aim: Actinomycetes are a group of Gram-positive bacteria with a fungus-like morphology. Their natural habitat encompasses terrestrial and water areas, including mangrove ecosystems.
Wilis Ari Setyati, Delianis Pringgenies, Nirwani Soenardjo, Rini Pramesti   +3 more
doaj   +1 more source

Oxygen concentration modulates colibactin production

Gut Microbes, 2023
Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite.
Nadège Bossuet, Cécile Guyonnet, Camille V Chagneau, Min Tang-Fichaux, Marie Penary, Dorian Loubet, Priscilla Branchu, Eric Oswald, Jean-Philippe Nougayrede   +8 more
doaj   +1 more source

In vitro activity of engineered EcN strains in the absence of pks.

, 2023
A) N-myristoyl-D-asparagine (colibactin biomarker) levels in supernatants of parental strains SYNB1618 (dark blue) and SYNB1934 (pink), while no biomarker is detected in Δpks SYNB1618 and Δpks SYNB1934. Data are the mean ± SD of 3 samples after growth in
Aida Kalantari (6731369), Mylene Perreault (2004913), Lauren A. Renaud (14559642), Mary N. McDonald (14559648), David L. Hava (14559651), Michael J. James (336941), Vincent M. Isabella (14559654), Catherine E. Monahan (14559645)   +7 more
core   +1 more source

Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic necrotizing factor (CNF) colonize laboratory macaques

Gut Pathogens, 2017
Background Many Escherichia coli strains are considered to be a component of the normal flora found in the human and animal intestinal tracts. While most E.
Yan Feng, Anthony Mannion, Carolyn M. Madden, Alton G. Swennes, Catherine Townes, Charles Byrd, Robert P. Marini, James G. Fox   +7 more
doaj   +1 more source

Shining a Light on Colibactin Biology

Toxins, 2021
Colibactin is a secondary metabolite encoded by the pks gene island identified in several Enterobacteriaceae, including some pathogenic Escherichia coli (E. coli) commonly enriched in mucosal tissue collected from patients with inflammatory bowel disease
Michael W. Dougherty, Christian Jobin
doaj   +1 more source