Results 11 to 20 of about 2,539 (164)

Insights into the acquisition of the pks island and production of colibactin in the Escherichia coli population. [PDF]

Microb Genom, 2021
The pks island codes for the enzymes necessary for synthesis of the genotoxin colibactin, which contributes to the virulence of Escherichia coli strains and is ...
Auvray F, Perrat A, Arimizu Y, Chagneau CV, Bossuet-Greif N, Massip C, Brugère H, Nougayrède JP, Hayashi T, Branchu P, Ogura Y, Oswald E.   +11 more
europepmc   +6 more sources

Prevalence of Escherichia coli Carrying pks Islands in Bacteremia Patients [PDF]

Annals of Laboratory Medicine, 2018
Escherichia coli can harbor genomic pks islands that code for a polyketide-peptide genotoxin known as colibactin. E. coli strains carrying pks islands trigger genetic instability. pks islands have been significantly associated with bacteremia. We investigated the molecular epidemiology of bacteremic E.
Lee, Eunyoung, Lee, Yangsoon
core   +7 more sources

Correction: Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients [PDF]

BMC Genomics
Chao Lv, Mohd Abdullah, Chun-Li Su, Weiye Chen, Nan Zhou, Zile Cheng, Yiwen Chen, Min Li, Kenneth W. Simpson, Ahmed Elsaadi, Yongzhang Zhu, Steven M. Lipkin, Yung-Fu Chang   +12 more
doaj   +3 more sources

Prevalence of pks-positive Escherichia coli in Japanese patients with or without colorectal cancer

Gut Pathogens, 2017
Background Recent studies show that some Escherichia coli strains possessing a gene cluster named the pks island might have a causative role in the development of human colorectal cancer (CRC).
Takayuki Shimpoh, Yoshihiro Hirata, Sozaburo Ihara, Nobumi Suzuki, Hiroto Kinoshita, Yoku Hayakawa, Yumiko Ota, Akiko Narita, Shuntaro Yoshida, Atsuo Yamada, Kazuhiko Koike   +10 more
doaj   +2 more sources

Prevalence of pks + bacteria and enterotoxigenic Bacteroides fragilis in patients with colorectal cancer

Gut Pathogens, 2022
Background Colorectal cancer (CRC) is the third most diagnosed cancer and the second most common cause of cancer deaths worldwide. CRC patients present with an increase in pathogens in their gut microbiota, such as polyketide synthase-positive bacteria ...
Manon Oliero, Roy Hajjar, Thibault Cuisiniere, Gabriela Fragoso, Annie Calvé, François Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Éric De Broux, Carole S. Richard, Manuela M. Santos   +13 more
doaj   +2 more sources

Prevalence and association of pks+ Escherichia coli with colorectal cancer in patients at the University Malaya Medical Centre, Malaysia.

PLoS ONE, 2020
Escherichia coli (E. coli) from the B2 phylogenetic group is implicated in colorectal cancer (CRC) as it possesses a genomic island, termed polyketide synthetase (pks), which codes for the synthesis of colibactin, a genotoxin that induces DNA damage ...
Thevambiga Iyadorai, Vanitha Mariappan, Kumutha Malar Vellasamy, Jane Wangui Wanyiri, April Camilla Roslani, Goh Khean Lee, Cynthia Sears, Jamuna Vadivelu   +7 more
doaj   +2 more sources

Correction to Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and Activity

Organic Letters, 2015
Correction to Isolation of a Metabolite from the pks Island Provides Insights into Colibactin Biosynthesis and ...
Carolyn A. Brotherton, Matthew Wilson, Gary Byrd, Emily P. Balskus   +3 more
openaire   +2 more sources

Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin

ACS Chemical Biology, 2016
Colibactin is a human gut bacterial genotoxin of unknown structure that has been linked to colon cancer. The biosynthesis of this elusive metabolite is directed by the pks gene cluster, which encodes a hybrid nonribosomal peptide synthetase-polyketide synthase (NRPS-PKS) assembly line that is hypothesized to use the unusual polyketide building block ...
Li, Zha, Matthew R, Wilson, Carolyn A, Brotherton, Emily P, Balskus   +3 more
openaire   +3 more sources

The role of the PKS island in polymicrobial interactions between Escherichia coli and Staphylococcus aureus during wound infections

, 2022
Wound infections are often polymicrobial in nature and are associated with poorer disease prognosis. Escherichia coli and Staphylococcus aureus are among the top five most cultured pathogens during wound infections.
Wong, Jun Jie
openaire   +2 more sources

Colibactin: More Than a New Bacterial Toxin

Toxins, 2018
Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new cyclomodulin called colibactin, which is synthetized by the pks genomic island, was discovered in 2006.
Tiphanie Faïs, Julien Delmas, Nicolas Barnich, Richard Bonnet, Guillaume Dalmasso   +4 more
doaj   +2 more sources